Ixekizumab vs. Etanercept for Plaque Psoriasis: Phase 3 Results Announced

Eli Lilly and Company announced results from its Phase 3 UNCOVER studies of ixekizumab for the treatment of moderate-to-severe plaque psoriasis. Ixekizumab is a monoclonal antibody with high affinity and specificity that binds to and neutralizes the pro-inflammatory cytokine interleukin-17A (IL-17A).

Patients enrolled in the UNCOVER studies had a confirmed diagnosis of chronic plaque psoriasis for at least six months prior to randomization. Additionally, at screening and at randomization they demonstrated at least 10% BSA of psoriasis, an Static Physician Global Assessment (sPGA) score of at least 3 and the Psoriasis Area and Severity Index (PASI) score of at least 12. UNCOVER-1 compared the safety and efficacy of different dosing regimens of ixekizumab to placebo after 12 weeks and 60 weeks of treatment. UNCOVER-2 and 3 evaluated different dosing regimens of ixekizumab compared to either placebo or etanercept for 12 weeks.

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Patients treated with both dosing regimens of ixekizumab had significantly greater levels of skin clearance compared to placebo and to etanercept at the 12-week endpoint. For patients treated with ixekizumab either every four weeks or every two weeks, between 78– 90% of patients achieved at least a 75% reduction in PASI score (PASI 75) at 12 weeks. Additionally, 31–41% of these patients achieved PASI 100, or clear skin, at week 12. For comparison, between 5–7% of patients treated with etanercept in the UNCOVER-2 and 3 studies achieved PASI 100.

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