FDA Approves Olysio Use in HIV Co-Infection, HCV Genotype 4

The Food and Drug Administration (FDA) has approved label changes for Olysio (simeprevir; Janssen) to include dosing recommendations for the treatment of hepatitis C virus (HCV)/HIV-1 co-infection, and to expand the indications and usage to include genotype 4 infection.

USPSTF Updates CRC Screening Recs for Patients Aged 50+

The U.S. Preventive Services Task Force (USPSTF) recommends colorectal cancer (CRC) screening starting at age 50 years and continuing through age 75 years.

Early Acetaminophen Doesn't Appear to Cut ICU Days

For intensive care unit (ICU) patients with fever due to probable infection, early administration of acetaminophen does not affect the number of ICU-free days.

Upper-Limb Remote Preconditioning No Help in Cardiac Sx

Upper-limb remote ischemic preconditioning (RIPC) is not beneficial for patients undergoing cardiac surgery, according to two studies published in the New England Journal of Medicine.

Researchers Urge Routine Screening for Child Abuse

The early signs of child abuse among infants and toddlers - head trauma, rib fractures, or abdominal injuries - are often missed, and that may be due in part to a lack of standardized screening.

CDC Warns of Drug-Resistant 'Superbug' in Multiple U.S. Cities

Surveillance of seven U.S. metropolitan areas found higher-than-expected levels of carbapenem-resistant Enterobacteriaceae (CRE) in Atlanta, Baltimore, and New York City.

Therapeutic Positioning May Not Affect Vital Parameters

For severely disabled patients with central neurological disorders, therapeutic positioning does not appear to affect vital parameters.

CAC Absence Reclassifies Half of Those Not Eligible for Statins

Inclusion of the coronary artery calcium (CAC) score improves coronary heart disease (CHD) risk prediction, while the absence of CAC reclassifies many patients as not eligible for statins.

Nitrites Can Aid Heart Failure With Preserved Ejection Fraction

In patients with heart failure with preserved ejection fraction (HFpEF), sodium nitrite infusion favorably reduces exercise-linked hemodynamic derangements of cardiac failure.

Guidelines Developed for Managing Conflicts of Interest

The Guidelines International Network has developed principles for disclosure and management of conflicts of interest (COIs) during the clinical practice guideline development process.