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Doxepin HCl Concentrate
Anxiety/OCD
Mood disorders
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Drug Name:

Doxepin HCl Concentrate Rx

Generic Name and Formulations:
Doxepin (as HCl) 10mg/mL.

Company:
Various generic manufacturers

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for Doxepin HCl Concentrate:

Anxiety.

Adult Dose for Doxepin HCl Concentrate:

Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild to moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only.

Children's Dose for Doxepin HCl Concentrate:

Not recommended.

See Also:

Doxepin HCl Capsules

Pharmacological Class:

Tricyclic.

Contraindications:

During or within 14 days of MAOIs. Acute post MI. Urinary retention. Glaucoma.

Warnings/Precautions:

Cardiovascular disease. Epilepsy. Suicidal tendencies. Psychosis. Diabetes. Avoid abrupt cessation. Poor metabolizers (those with reduced CYP2D6 activity). Elderly. Pregnancy. Nursing mothers.

Interactions:

Hyperpyretic crisis, convulsions, death with MAOIs. Potentiates CNS depression of alcohol; cimetidine; other CYP2D6 substrates. Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. May block guanethidine.

Adverse Reactions:

CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects.

Note:

Formerly known under the brand name Sinequan.

How Supplied:

Contact supplier.

Indications for Doxepin HCl Concentrate:

Depression.

Adult Dose for Doxepin HCl Concentrate:

Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild to moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only.

Children's Dose for Doxepin HCl Concentrate:

Not recommended.

See Also:

Doxepin HCl Capsules

Pharmacological Class:

Tricyclic.

Contraindications:

During or within 14 days of MAOIs. Acute post MI. Urinary retention. Glaucoma.

Warnings/Precautions:

Cardiovascular disease. Epilepsy. Suicidal tendencies. Psychosis. Diabetes. Avoid abrupt cessation. Poor metabolizers (those with reduced CYP2D6 activity). Elderly. Pregnancy. Nursing mothers.

Interactions:

Hyperpyretic crisis, convulsions, death with MAOIs. Potentiates CNS depression of alcohol; cimetidine; other CYP2D6 substrates. Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. May block guanethidine.

Adverse Reactions:

CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects.

Note:

Formerly known under the brand name Sinequan.

How Supplied:

Contact supplier.

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