Susceptible complicated intra-abdominal and complicated urinary tract infections (including pyelonephritis).
Give by IV infusion over 1 hr; may switch to oral antibiotics after 3 days. ≥18yrs (CrCl >50mL/min): Intra-abdominal: 500mg every 8 hrs for 5–14 days. UTI, pyelonephritis: 500mg every 8 hrs for 10–14 days. CrCl 30–50mL/min: 250mg every 8 hrs; CrCl>10–<30mL/min: 250mg every 12 hrs.
<18yrs: not recommended.
Pregnancy (Cat.B). Nursing mothers.
Antagonizes valproic acid (monitor valproate frequently). Potentiated by probenecid (not recommended).
Headache, nausea, diarrhea (may be serious; evaluate if occurs), rash, phlebitis, anemia, hypersensitivity reactions.