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DORIBAX
Bacterial infections
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Drug Name:

DORIBAX Rx

Generic Name and Formulations:
Doripenem (as monohydrate) 500mg/vial; pwd; for IV infusion after constitution and dilution; preservative-free.

Company:
Janssen Pharmaceuticals, Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for DORIBAX:

Susceptible complicated intra-abdominal and complicated urinary tract infections (including pyelonephritis).

Adult Dose for DORIBAX:

Give by IV infusion over 1 hr; may switch to oral antibiotics after 3 days. ≥18yrs (CrCl >50mL/min): Intra-abdominal: 500mg every 8 hrs for 5–14 days. UTI, pyelonephritis: 500mg every 8 hrs for 10–14 days. CrCl 30–50mL/min: 250mg every 8 hrs; CrCl>10–<30mL/min: 250mg every 12 hrs.

Children's Dose for DORIBAX:

<18yrs: not recommended.

Pharmacological Class:

Carbapenem.

Contraindications:

Beta-lactam allergy.

Warnings/Precautions:

Pregnancy (Cat.B). Nursing mothers.

Interactions:

Antagonizes valproic acid (monitor valproate frequently). Potentiated by probenecid (not recommended).

Adverse Reactions:

Headache, nausea, diarrhea (may be serious; evaluate if occurs), rash, phlebitis, anemia, hypersensitivity reactions.

How Supplied:

Single-use vials—10