DIURIL INJ Rx

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DIURIL INJ

Edema
Only 4 drugs may be compared at once

Generic Name and Formulations:

Chlorothiazide (as sodium) 500mg/vial; pwd for IV inj after reconstitution; contains mannitol.

Company:

Akorn, Inc.

Select therapeutic use:

Indications for DIURIL INJ:

Edema.

Adult:

0.5–1g IV once or twice daily.

Children:

Not recommended.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+ -sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (thiazide).

Adverse Reactions:

Electrolyte disorders (especially hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

How Supplied:

Vial—1