DIPHTHERIA AND TETANUS TOXOIDS ADSORBED (for PEDIATRIC USE) Rx

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DIPHTHERIA AND TETANUS TOXOIDS ADSORBED (for PEDIATRIC USE)

Vaccines
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Generic Name and Formulations:

Tetanus and diphtheria toxoids; aluminum adsorbed; susp for IM inj; multi-dose vial preserved with thimerosal, single-dose vials contain trace amounts of thimerosal.

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Indications for DIPHTHERIA AND TETANUS TOXOIDS ADSORBED (for PEDIATRIC USE):

Tetanus and diphtheria immunization in patients 6 weeks to 7yrs of age when pertussis vaccine cannot be used.

Children:

<6wks and ≥7yrs: not recommended. Give IM in anterolateral thigh or deltoid. 6wks–1yr: three 0.5mL doses 4–8 weeks apart, then 4th dose 6–12 months after third dose. 1–6yrs (up to 7yrs): two 0.5mL doses 4–8 weeks apart, then 3rd dose 6–12 months after the second dose (if >7yrs, use Td vaccine). Booster dose: see literature.

Contraindications:

History of systemic allergic or neurologic reactions to a previous dose of DT.

Warnings/Precautions:

Defer in moderate or severe active respiratory or other febrile infection (may vaccinate if mild or minor illness) or during polio outbreak. Bleeding disorders. Immunosuppressed. Have epinephrine (1:1000) available.

Interactions:

May get suboptimal response with immunosuppressants (eg, chemotherapy, high dose corticosteroids ≥2 weeks, radiation); consider deferring.

Pharmacological Class:

DT vaccine.

Adverse Reactions:

Local reactions (eg, erythema, edema), malaise, fever, hypotension, arthralgia, nausea; rare: neurologic disorders.

How Supplied:

Single-dose vials—10
Multi-dose vial (5mL)—1