Digestive And Biliary Disorders

Pediatric Ulcerative Colitis Tx Granted Orphan Drug Status

By December 04, 2017

The designation is based on a review of Phase 1b clinical data which showed potential for SER-287 as a novel treatment modality for patients with UC

Fecal Microbial Transplant via Oral Capsule Versus Colonoscopy

November 29, 2017

The researchers found that prevention of recurrent CDI after a single treatment was achieved by 96.2% of participants in the capsule and colonoscopy groups in the per-protocol analysis (difference, 0%), meeting the criterion for noninferiority.

In ART-Treated HIV Patients With GI Discomfort, Consider EPI Assessment

By November 13, 2017

Of 100 participants, 32% had EPI (faecal elastase-1 <200 μg/g) and 20% severe EPI (faecal elastase-1 <100 μg/g).

Less Common Causes of Exocrine Pancreatic Insufficiency Explored

By November 13, 2017

Untreated celiac disease was also associated with EPI in 4% to 80% of cases but was resolved when patients adopted a gluten-free diet.

Haloperidol Plus Conventional Tx Effective for Symptomatic Gastroparesis

By October 26, 2017

Haloperidol was superior to placebo in reducing nausea and pain.

Fecal Transplant Efficacy Examined for Chronic Liver Disease

October 16, 2017

The researchers found that by week 26, three of six patients had a ≥50% decrease in alkaline phosphatase (ALP), with an average decrease of 250 versus 10 for responders versus nonresponders.

Post-Op Outcomes for Individualized vs. Standard Blood Pressure Tx

September 27, 2017

The researchers found that the primary outcome event occurred in 38.1 and 51.7% of patients assigned to the individualized treatment group and standard treatment strategy group, respectively.

Salt Intake Beliefs Examined in Patients Undergoing Hemodialysis

September 25, 2017

Patients who had versus those who had not received a transplant had a significantly higher score for the subscale of perceived seriousness for no reduction of sodium intake (P<0.01).

NDA Submitted for Thrombocytopenia Treatment

By September 22, 2017

The results from Phase 3 trials demonstrated efficacy and safety in patients with severe thrombocytopenia and with CLD.

FDA: Cases of Severe Liver Injury with PBC Drug Due to Incorrect Dosing

By September 21, 2017

Patients with moderate to severe decline in hepatic function have been receiving excessive dosing at a frequency higher than what is recommended for this specific population.

First Duodenoscope with Disposable Distal Cap Cleared by FDA

By September 20, 2017

The Pentax ED34-i10T duodenoscope is intended to provide visualization and access to the upper gastrointestinal tract to treat bile duct disorders and other upper GI problems.

Airplane Medical Emergencies: Is it a Physician's Duty to Help?

September 13, 2017

In the United States, Canada, and United Kingdom, physicians do not have the legal duty to assist unless there is a prior patient-physician relationship.

Biosimilar Cyltezo Gets FDA Approval for Multiple Indications

By August 28, 2017

This marks the second approval of a biosimilar for adalimumab.

Light, Moderate Alcohol Intake May Protect Against All-Cause, CVD Death

August 15, 2017

Risk of mortality for all causes, cancer up for adults with heavy alcohol consumption, binge drinking.

Diuretic Linked to Acute Pancreatitis in Patient with Coronary Artery Disease

By August 14, 2017

Furosemide-induced acute pancreatitis can occur several hours to up to 7 weeks after starting treatment; dose may also play a role. This patient, the authors note, fell into the category of "long-term latency" and "low-dosage (40mg)"

Gastroenteritis Hospitalizations Down with Rotavirus Vaccine Introduction

August 11, 2017

The researchers found that 16% of the 1,253,951 AGE-related hospitalizations among children aged <5 years were coded as a rotavirus-related hospitalization.

Ipragliflozin vs. Pioglitazone in T2DM Complicated by Liver Disease

August 03, 2017

"Compared with pioglitazone, ipragliflozin exerts equally beneficial effects on NAFLD and glycemic control during the treatment of patients with type 2 diabetes complicated by NAFLD," the authors write.

Obeticholic Acid + Statin Shows Rapid Reversal of LDL Rise in NASH Patients

By August 02, 2017

The mean LDL change from baseline to Week 16 were as follows: placebo: -48 mg/dL, OCA 5mg: -40mg/dL, OCA 10mg: -40mg/dL, and OCA 25mg: -45mg/dL.

Serum &#947;-Glutamyltransferase Levels May ID MetS in Children

July 28, 2017

After adjustment for age, household income, and residential area, the multivariable-adjusted odds ratios for MetS for the upper stratum were 5.79 and 6.20 in boys and girls, respectively.

Updated Prescribing Information for ChiRhoStim

By July 25, 2017

ChiRhoStim is available as 16mcg and 40mcg strength lyophilized powder in single-dose vials for reconstitution.

FDA Expands Use of RELiZORB to Include Children

By July 20, 2017

In the study, authors measured plasma omega-3 fatty acid concentrations as markers of fat absorption. Safety and tolerability were assessed by documentation of gastrointestinal (GI) symptoms.

Patient Develops Acute Liver Failure Following Amiodarone Infusion

July 19, 2017

The researchers describe a 79-year-old woman who was admitted with atrial flutter and treated with intravenous (IV) amiodarone. She developed coagulopathy, altered mental status, and derangement of liver enzymes.

Guidance Document Revises Management Practices in NAFLD

July 19, 2017

Pharmacologic treatments aimed at improving liver disease should be limited to those with biopsy-proven nonalcoholic liver steatohepatitis (NASH) and fibrosis.

Diagnosing and Treating Exocrine Pancreatic Insufficiency

By July 17, 2017

A recent opinion piece by Struyvenberg et al. aims to address the existing myths, remove the current confusion, and function as a practical guide to the diagnosis and treatment of EPI.

How Common Is EPI in Patients with Chronic Abdominal Pain, Diarrhea?

By July 17, 2017

Overall, pancreatic exocrine insufficiency was identified in 10 patients (4.6%; 95% CI 2.2-8.3%) with five patients having severe pancreatic exocrine insufficiency (2.3%; 95% CI 0.8-5.3%).

Delayed-Release Pancreatic Enzyme Product Approved for G-Tube Administration

By July 14, 2017

The Pertzye labeling describes the required steps for administering the 4,000 lipase units capsule through the G-tube. Only the contents of the 4,000 lipase units capsule should be used for G-tube administration and no more than two capsules should be administered at a time.

Daily Coffee Consumption Tied to Lower Liver Stiffness, Less Scarring

June 14, 2017

Researchers examined data on 2,424 Dutch individuals age 45 or older who did not have liver disease and found that regardless of their lifestyle and environment coffee consumption had protective effects.

Patient with Cirrhosis Develops Severe Hyperammonemia After Blood Transfusion

June 14, 2017

Following administration of 1 unit of packed red blood cells that had been collected 17 days earlier, the patient's serum ammonia level was 806 µmol/L, compared with 53 µmol/L on admission.

New CRAC Channel Inhibitor for Acute Pancreatitis Fast-Tracked

By May 24, 2017

In Phase 1 safety studies, CM4620 showed positive activity in vivo in several animal models. CalciMedica plans to begin the first of its patient studies early in 2018.

Gimoti Shows Benefit in Moderate to Severe Diabetic Gastroparesis

By May 11, 2017

Results showed that the primary efficacy endpoint of change from baseline to week 4 was not statistically met (P=0.881), although a significant treatment benefit was seen in patients with moderate to severe symptoms (P<0.05).