Digestive And Biliary Disorders

Light, Moderate Alcohol Intake May Protect Against All-Cause, CVD Death

August 15, 2017

Risk of mortality for all causes, cancer up for adults with heavy alcohol consumption, binge drinking.

Diuretic Linked to Acute Pancreatitis in Patient with Coronary Artery Disease

By August 14, 2017

Furosemide-induced acute pancreatitis can occur several hours to up to 7 weeks after starting treatment; dose may also play a role. This patient, the authors note, fell into the category of "long-term latency" and "low-dosage (40mg)"

Gastroenteritis Hospitalizations Down with Rotavirus Vaccine Introduction

August 11, 2017

The researchers found that 16% of the 1,253,951 AGE-related hospitalizations among children aged <5 years were coded as a rotavirus-related hospitalization.

Ipragliflozin vs. Pioglitazone in T2DM Complicated by Liver Disease

August 03, 2017

"Compared with pioglitazone, ipragliflozin exerts equally beneficial effects on NAFLD and glycemic control during the treatment of patients with type 2 diabetes complicated by NAFLD," the authors write.

Obeticholic Acid + Statin Shows Rapid Reversal of LDL Rise in NASH Patients

By August 02, 2017

The mean LDL change from baseline to Week 16 were as follows: placebo: -48 mg/dL, OCA 5mg: -40mg/dL, OCA 10mg: -40mg/dL, and OCA 25mg: -45mg/dL.

Serum &#947;-Glutamyltransferase Levels May ID MetS in Children

July 28, 2017

After adjustment for age, household income, and residential area, the multivariable-adjusted odds ratios for MetS for the upper stratum were 5.79 and 6.20 in boys and girls, respectively.

Updated Prescribing Information for ChiRhoStim

By July 25, 2017

ChiRhoStim is available as 16mcg and 40mcg strength lyophilized powder in single-dose vials for reconstitution.

FDA Expands Use of RELiZORB to Include Children

By July 20, 2017

In the study, authors measured plasma omega-3 fatty acid concentrations as markers of fat absorption. Safety and tolerability were assessed by documentation of gastrointestinal (GI) symptoms.

Patient Develops Acute Liver Failure Following Amiodarone Infusion

July 19, 2017

The researchers describe a 79-year-old woman who was admitted with atrial flutter and treated with intravenous (IV) amiodarone. She developed coagulopathy, altered mental status, and derangement of liver enzymes.

Guidance Document Revises Management Practices in NAFLD

July 19, 2017

Pharmacologic treatments aimed at improving liver disease should be limited to those with biopsy-proven nonalcoholic liver steatohepatitis (NASH) and fibrosis.

Diagnosing and Treating Exocrine Pancreatic Insufficiency

By July 17, 2017

A recent opinion piece by Struyvenberg et al. aims to address the existing myths, remove the current confusion, and function as a practical guide to the diagnosis and treatment of EPI.

How Common Is EPI in Patients with Chronic Abdominal Pain, Diarrhea?

By July 17, 2017

Overall, pancreatic exocrine insufficiency was identified in 10 patients (4.6%; 95% CI 2.2-8.3%) with five patients having severe pancreatic exocrine insufficiency (2.3%; 95% CI 0.8-5.3%).

Delayed-Release Pancreatic Enzyme Product Approved for G-Tube Administration

By July 14, 2017

The Pertzye labeling describes the required steps for administering the 4,000 lipase units capsule through the G-tube. Only the contents of the 4,000 lipase units capsule should be used for G-tube administration and no more than two capsules should be administered at a time.

Daily Coffee Consumption Tied to Lower Liver Stiffness, Less Scarring

June 14, 2017

Researchers examined data on 2,424 Dutch individuals age 45 or older who did not have liver disease and found that regardless of their lifestyle and environment coffee consumption had protective effects.

Patient with Cirrhosis Develops Severe Hyperammonemia After Blood Transfusion

June 14, 2017

Following administration of 1 unit of packed red blood cells that had been collected 17 days earlier, the patient's serum ammonia level was 806 µmol/L, compared with 53 µmol/L on admission.

New CRAC Channel Inhibitor for Acute Pancreatitis Fast-Tracked

By May 24, 2017

In Phase 1 safety studies, CM4620 showed positive activity in vivo in several animal models. CalciMedica plans to begin the first of its patient studies early in 2018.

Gimoti Shows Benefit in Moderate to Severe Diabetic Gastroparesis

By May 11, 2017

Results showed that the primary efficacy endpoint of change from baseline to week 4 was not statistically met (P=0.881), although a significant treatment benefit was seen in patients with moderate to severe symptoms (P<0.05).

Enzyme May Make Some Foods 'Safer' For Gluten-Sensitive

By May 08, 2017

However the authors emphasized that the enzyme was not tested and is not recommended for use in patients with celiac disease, as even a small amount of gluten can inflict long-term damage in these patients.

Vitamin D Review Looks at Risk Factors for Deficiency, Treatment Protocols

By May 01, 2017

Protection against skin cancer is important but "moderate levels of unprotected sun exposure can be very helpful in boosting vitamin D."

Avocado May Benefit in Metabolic Syndrome

By April 11, 2017

Researchers conducted a review of 129 articles concerning avocado consumption.

AGA: Best Practices for Prescribing PPIs

By April 07, 2017

While the benefits of treatment should be weighed against the risks on an individual basis, the AGA has provided recommendations to help clinicians make treatment decisions with regards to PPI use.

Environmental Toxins Linked to Multiple Diseases, Early Puberty

By April 07, 2017

These studies identified links to increased risks of thyroid, testicular and breast cancer, nonalcoholic fatty liver disease and even the early onset of puberty for boys, which can lead to diseases in adulthood.

NAFLD Drug Therapy Review Offers Little Clarity on Optimal Treatment

By March 31, 2017

The authors concluded that they were "very uncertain about the effectiveness of pharmacological treatments for people with NAFLD including those with steatohepatitis."

USPSTF Issues Statement on Celiac Disease Screening

By March 28, 2017

Overall, the Task Force did not find enough evidence on the accuracy of screening for celiac disease in asymptomatic patients.

VIDEO: Gluten-Free but Not Toxic-Free?

February 15, 2017

The authors hypothesize that the higher levels could be due to gluten-free products using rice flour as a substitute for wheat.

FDA Issues Safety Alert for Obesity Treatment

February 14, 2017

The FDA has received several dozen adverse event reports regarding balloon over-inflation for two fluid-filled intragastric weight-loss systems.

Kidney Outcomes Assessed for Valsartan Therapy in IGT Patients

February 09, 2017

For patients with impaired glucose tolerance (IGT), valsartan is associated with reduced incidence of microalbuminuria, according to a study published online January 17 in Diabetes, Obesity and Metabolism.

Strategies to Improve HCC Screening in Cirrhosis Patients Compared

February 08, 2017

Outreach strategies increase the percentage of patients with cirrhosis who undergo hepatocellular carcinoma (HCC) screening.

Big Events Linked to Increased Risk of This Emergency Procedure

By February 03, 2017

An 11-year study has found that people are 10 times more likely to need an emergency procedure on the esophagus during or just after a national sporting event such as the Super Bowl and other national holidays.

What Foods are Associated With Gallstone-Related Acute Pancreatitis?

January 30, 2017

Dietary factors are associated with pancreatitis, with saturated fat and cholesterol positively linked to gallstone-related acute pancreatitis (AP), according to a study published in Clinical Gastroenterology and Hepatology.