DIFLUCAN
Generic Name for DIFLUCAN
Fluconazole 50mg, 100mg, 200mg; tabs.
Legal Classification:
Rx
Pharmacological Class for DIFLUCAN
Azole.
Manufacturer of DIFLUCAN
Pfizer Labs
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Indications for DIFLUCAN
Oropharyngeal, esophageal, systemic candidiasis. Bone marrow transplant prophylaxis. Cryptococcal meningitis. Candida urinary tract infection (UTI), peritonitis.
Adult dose for DIFLUCAN
Individualize. CrCl<50mL/min: reduce dose, see literature. All doses are once daily. Oropharyngeal candidiasis: 200mg on day 1, then 100mg/day for at least 2 wks. Esophageal candidiasis: 200mg on day 1, then 100mg/day for at least 3 wks; treat for at least 2 wks after symptoms resolve; max 400mg/day. Systemic candidiasis: doses of up to 400mg/day have been used. Prophylaxis of candidiasis in bone marrow transplantation: 400mg/day. Cryptococcal meningitis: 400mg on day 1, then 200–400mg/day for 10–12 wks after spinal fluid negative; to suppress relapse in AIDS: 200mg/day. UTI, peritonitis: 50–200mg/day have been used.
Children's dosing for DIFLUCAN
Individualize. CrCl<50mL/min: reduce dose, see literature. All doses are once daily. Neonates: see literature. Over 2 wks of age: Oropharyngeal candidiasis: 6mg/kg on day 1, then 3mg/kg/day for at least 2 wks. Esophageal candidiasis: 6mg/kg on day 1, then 3mg/kg/day for at least 3 wks; treat for at least 2 wks after symptoms resolve; max 12mg/kg/day. Systemic candidiasis: 6–12mg/kg/day have been used. Cryptococcal meningitis: 12mg/kg on day 1, then 6mg/kg/day for 10–12 wks after negative CSF cultures; max 12mg/kg/day; to suppress relapse in AIDS: 6mg/kg/day. Max for all: 600mg/day.
Also:
Contraindications for DIFLUCAN
Concomitant cisapride.
Warnings/Precautions for DIFLUCAN
Proarrhythmic conditions. Monitor liver function. Discontinue if liver disease or progressively worsening rash develops. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for DIFLUCAN
See Contraindications. Potentiates warfarin, theophylline, oral hypoglycemics, midazolam. May increase serum levels of phenytoin, cyclosporine, zidovudine, sulfonylureas. Thiazides increase fluconazole levels. Monitor levels and/or effects of cyclosporine, phenytoin, sulfonylureas, rifabutin, tacrolimus, theophylline, warfarin. Cimetidine (oral), rifampin may decrease fluconazole levels. Oral contraceptives: see literature. Avoid other hepatotoxic drugs. Caution with other drugs metabolized by CYP450.
Adverse Reactions for DIFLUCAN
Nausea, headache, rash, vomiting, abdominal pain, diarrhea; hepatotoxicity, exfoliative dermatitis (rare).
How is DIFLUCAN supplied?
Tabs—30
Susp (35mL)—1
IV (200mg, 400mg)—6
Related Disease:
Infections, fungal~systemic antifungals