150mg orally once.
Concomitant pimozide, quinidine.
Proarrhythmic conditions. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
See Contraindications. Risk of cardiotoxicity with erythromycin; avoid. Concomitant voriconazole: not recommended; if needed, monitor closely esp. when given within 24hrs after fluconazole. Potentiates warfarin, theophylline, oral hypoglycemics, midazolam. May increase serum levels of phenytoin, cyclosporine, zidovudine, sulfonylureas, carbamazepine. Thiazides increase fluconazole levels. Monitor levels and/or effects of cyclosporine, phenytoin, sulfonylureas, rifabutin, tacrolimus, theophylline, warfarin. Cimetidine (oral), rifampin may decrease fluconazole levels. Oral contraceptives: see literature. Avoid other hepatotoxic drugs. Caution with other drugs metabolized by CYP450.
Headache, nausea, abdominal pain, GI upset, dizziness, taste perversion; hepatotoxicity, exfoliative dermatitis (rare).