Select therapeutic use:
Indications for DIDREX:
Short-term adjunct in management of exogenous obesity.
Initially 25–50mg daily in mid-morning or mid-afternoon. Increase if needed to 25–50mg 1–3 times daily.
Advanced arteriosclerosis. Cardiovascular disease. Hypertension. Hyperthyroidism. Agitation. Drug or alcohol abuse. During or within 14 days of MAOIs. Pregnancy (Cat.X).
Discontinue after a few weeks as tolerance to anorectic effect occurs. Diabetes. Prescribe limited supply to prevent overdose. Nursing mothers: not recommended.
Hypertensive crisis with MAOIs. Blocks guanethidine. Altered insulin requirements. Potentiated by urinary alkalinizers. Antagonized by urinary acidifiers.
Abuse potential, impairment in hazardous activities, arrhythmias, hypertension, CNS overstimulation, psychosis, dry mouth, GI disturbances, urticaria, impotence.