Diazepam Oral Solution CIV

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Diazepam Oral Solution

Anxiety/OCD
Muscle spasms
Seizure disorders
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Generic Name and Formulations:

Diazepam 5mg; per 5mL; wintergreen-spice flavor.

Select therapeutic use:

Indications for Diazepam Oral Solution:

Anxiety.

Adult:

Intensol: Mix with liquid or semi-solid food. 2–10mg 2–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually.

Children:

Intensol: mix with liquid or semi-solid food. <6months: see Contraindications. >6months: 1–2.5mg 3–4 times daily; increase gradually.

Contraindications:

Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.

Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Drug or alcohol abuse. May increase severity of seizures. Renal or hepatic impairment. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Elderly. Debilitated. Labor & delivery. Psychosis, pregnancy, nursing mothers: not recommended.

Interactions:

Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.

See Also:

Diazepam Intensol

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement.

How Supplied:

Soln—500mL; Intensol—30mL (w. dropper)

Indications for Diazepam Oral Solution:

Adjunct for skeletal muscle spasm.

Adult:

Intensol: Mix with liquid or semi-solid food. 2–10mg 3–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually.

Children:

Intensol: mix with liquid or semi-solid food. <6months: see Contraindications. >6months: 1–2.5mg 3–4 times daily; increase gradually.

Contraindications:

Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.

Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Drug or alcohol abuse. May increase severity of seizures. Renal or hepatic impairment. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Elderly. Debilitated. Labor & delivery. Psychosis, pregnancy, nursing mothers: not recommended.

Interactions:

Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.

See Also:

Diazepam Intensol

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement.

How Supplied:

Soln—500mL; Intensol—30mL (w. dropper)

Indications for Diazepam Oral Solution:

Adjunct in convulsive disorders.

Adult:

Intensol: Mix with liquid or semi-solid food. 2–10mg 2–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually.

Children:

Intensol: mix with liquid or semi-solid food. <6months: see Contraindications. >6months: 1–2.5mg 3–4 times daily; increase gradually.

Contraindications:

Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.

Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Drug or alcohol abuse. May increase severity of seizures. Renal or hepatic impairment. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Elderly. Debilitated. Labor & delivery. Psychosis, pregnancy, nursing mothers: not recommended.

Interactions:

Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.

See Also:

Diazepam Intensol

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement.

How Supplied:

Soln—500mL; Intensol—30mL (w. dropper)