Diabetes

Prenatal Falling Insulin Requirement Linked to Complications

August 16, 2017

The researchers found that FIR ≥15% correlated with an increased risk of the composite primary outcome (odds ratio, 4.38) and preeclampsia (odds ratio, 6.76), and was more common among women with type 1 diabetes (36.6 versus 14.5%)

First-in-Class Dual SGLT1/2 Inhibitor Shows Sustained HbA1c Reduction

By August 16, 2017

The overall mean placebo-adjusted A1C reduction at week 24 was 0.37% in the 200mg dose arm (P<0.001) and 0.35% in the 400mg dose arm (P<0.001), this was sustained over the 52-week duration of the study.

Sleep Duration and Diabetes Risk in Children: What's the Link?

August 15, 2017

A one-hour longer sleep duration correlated with 0.19 kg/m² lower body mass index, 0.03 kg/m5 lower fat mass index, 2.9% lower homeostasis model assessment of insulin resistance, and 0.24% lower fasting glucose.

Exendin Assessed for Post-Bariatric Complications

August 11, 2017

The postprandial glucose nadir was increased by 66%, peak insulin was reduced by 57%, and neuroglycopenic symptoms were reduced by 80%, on average.

Combating Diabetes Through Online Gaming

August 11, 2017

Among patients with baseline HbA1c >75 mmol/mol, HbA1c reductions were greater (−16 and −9 mmol/mol for DSME and civics game patients, respectively; P=0.031).

Peptide Immunotherapy Shows Potential in Modulating Type 1 Diabetes

August 10, 2017

The researchers found that the peptide treatment was well tolerated, with no evidence of systemic or local hypersensitivity. There was a significant decline in stimulated C-peptide at three, 6, 9, and 12 months.

Mutation Subtypes ID'd in Infant Diabetes

August 09, 2017

The researchers found that the most common form of infancy-onset diabetes was KCNJ11-related diabetes (37.5%), followed by "unknown" (likely type 1 diabetes; 21.6%).

Ipragliflozin vs. Pioglitazone in T2DM Complicated by Liver Disease

August 03, 2017

"Compared with pioglitazone, ipragliflozin exerts equally beneficial effects on NAFLD and glycemic control during the treatment of patients with type 2 diabetes complicated by NAFLD," the authors write.

Publication of Drug Interaction Unlikely to Impact Prescribing Patterns

By August 02, 2017

The findings point to "minimal to no measurable effect" in lowering the concomitant use.

Canagliflozin CV Biomarker Effects Examined in Diabetes Patients

August 02, 2017

The researchers observed increases in serum NT-proBNP and serum hsTnI levels in placebo recipients, but these levels remained largely unchanged in canagliflozin recipients.

Alcohol Consumption and Diabetes Risk: What's the Link?

July 31, 2017

Wine appears to provide the most protective benefit, researchers say

PCP Survey Reveals Most Don't Know All the Risk Factors for Prediabetes

July 26, 2017

Fewer than one in 10 PCPs surveyed named all risk factors identified by American Diabetes Association

Is Fasting Plasma Glucose a Predictor of Alzheimer's in T2D?

July 25, 2017

Both FPG CV and HbA1c CV were significant predictors of AD after adjustment for sociodemographic factors, lifestyle behaviors, diabetes-related variables, FPG and HbA1c, drug-related variables, and comorbidities.

'Overfat' Pandemic Grows Even as Obesity Rates Level Off

July 25, 2017

Traditional methods of measuring weight or body mass index are ineffective in assessing whether a person is overfat, the study authors said.

Diet, Physical Activity During Pregnancy May Influence C-Section Risk

July 21, 2017

The researchers found that, overall, interventions were associated with a 9% reduction in risk of cesarean section, and a 24% reduction in risk of developing gestational diabetes.

Lusduna Nexvue Gets Tentative Approval from FDA

By July 20, 2017

The product has satisfied all regulatory requirements for follow-on biologics regarding safety, efficacy, and quality but is subject to an automatic stay pending the outcome of a patent infringement lawsuit.

Weight Gain During Adulthood Ups Risk of Major Chronic Diseases

July 20, 2017

As little as 11 pounds gained from early to middle adulthood tied to significantly elevated risk

CDC Releases New Diabetes Report with County-Level Data

July 20, 2017

By U.S. region, the South and Appalachia had the highest rates of diagnosed diabetes and new diabetes cases.

Diabetes Treatments Compared for Bladder Cancer Risk

By July 17, 2017

The greatest incidence of bladder cancer was among the group who initiated pioglitazone treatment, in which there were 308 cases per 100,000 person-years.

The Rate of At-Home Medication Errors Has Doubled

July 11, 2017

The rate of serious medication errors rose from 1.09 for every 100,000 Americans in 2000 to 2.28 per 100,000 by 2012.

HCV Eradication Linked to Improved Glycemic Control in Patients with Diabetes

July 07, 2017

Improved glycemic control, reduced antidiabetic medication use with sustained virologic response

Use of Hyperbaric Therapy Increasing, Especially Among Diabetic Patients

July 06, 2017

Hyperbaric therapy increasing for diabetic wounds, although it is not recommended by ADA

Recall: Insulin Pen Devices with Damaged Cartridge Holders ID'd

By July 05, 2017

The affected batches were distributed between 8/1/2016 - 6/22/2017 and have the following batch numbers: EVG1221, EVG1226, FVG7149, FVG7458, FVG8134, FVG8135.

Hypoglycemia Rates Compared for Two Long-Acting Insulins

By July 05, 2017

Researchers measured the rate of overall severe or blood glucose-confirmed (<56mg/dL) symptomatic hypoglycemic episodes during the maintenance period (primary endpoint).

Immunological Differences in &#946;-Cell Function Among T1DM Patients

July 05, 2017

The investigators found that approximately 40% of patients with type 1 diabetes and 10 or more years disease duration had measurable fasting C-peptide concentrations.

Effects of Empagliflozin Examined in Impaired Fasting Glucose

June 28, 2017

Researchers treated 8 subjects with normal fasting glucose and 8 with impaired fasting glucose with empagliflozin for 2 weeks.

Review: Diabetic Foot Ulcer Treatments Compared

By June 27, 2017

Participants in the antimicrobial-dressing treatment arm experienced an additional 119 healing events. However, the researchers considered this "low-certainty evidence," due to risk of bias.

Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain

By June 26, 2017

Their findings demonstrated that 3 or 4 out of 10 participants achieved this degree of pain relief with gabapentin, vs. 1 or 2 out of 10 for placebo.

Best Care Practices Highlighted for Comorbid T2DM and Osteoporosis

June 26, 2017

In the setting of coexisting disease, the preferred treatment options for T2DM are sulfonylureas, dipeptidyl peptidase-4 inhibitors, and glucagon-like peptide-1 receptor agonists, while strict targets should be avoided due to risks of hypoglycemia, falls, and fractures.

sRAGE and Diabetic Nephropathy: Is There a Link?

June 22, 2017

The researchers found that the estimated 5-year incidence of DN was 15%. Higher levels of sRAGE were significantly associated with incidence of DN after adjustment for duration of diabetes.