In AWARD-7, eligible patients (N=577) were randomized to receive dulaglutide 1.5mg once-weekly (N=193), dulaglutide 0.75mg (N=190) once-weekly, or insulin glargine daily (N=194), all in combination with insulin lispro, for 52 weeks. HbA1c at 26 weeks with a 0.4% non-inferiority margin was designated as the primary outcome, while secondary outcomes included eGFR and urine albumin-to-creatinine ratio.
In most patients with type 2 diabetes, the target should be an HbA1c level between 7 and 8%. For patients with type 2 diabetes and HbA1c levels <6.5%, deintensification of pharmacologic therapy should be considered.
"Cleared BGMs do not always meet the level of analytical accuracy currently required for regulatory clearance," the authors write.
NT-proBNP at baseline was independently linked to development of major CV events, in particular hospitalization for heart failure, after adjustment for potential confounders.
Currently, at least 5 states and a federal prosecutor are seeking information from insulin manufacturers and pharmacy benefit managers, and class action lawsuits have been filed on behalf of patients.
The researchers found that 67.3, 10.6, and 22.1% of the 261,765 reconciliation assessment periods contributed by 31,689 patients had some, all, or none of the diabetes medications reconciled, respectively.
According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using this database.
Researchers compared cognition in 82 individuals with 50 or more years of type 1 diabetes (Medalists), 31 age-matched individuals with type 2 diabetes, and 30 age-matched control subjects without diabetes.
Cost savings were estimated at $66.9 and $135 billion, respectively, if the diet quality of US adults were to improve to achieve 80% of the maximum healthy eating index 2015 and mediterranean diet scores.
Participants with erectile dysfunction were more likely to have diabetes mellitus; a family history of CHD; and to use β-blocker, antihypertensive, lipid-lowering, and antidepressant medications.
In the first 2 years after cancer diagnosis, the excess risk for diabetes was highest, and it remained elevated throughout follow-up.
Results demonstrated an incidence rate of 391/100,000 person years was calculated based on the 163 patients who were hospitalized with lactic acidosis during the follow-up period.
The Omnipod DASH system consists of a discreet, tubeless, waterproof Pod which is worn on the body, and the Personal Diabetes Manager (PDM), a handheld wireless device used to control the Pod.
Oral semaglutide 14mg led to statistically significant improvement in hemoglobin A1c levels and weight loss in adults with type 2 diabetes.
The likelihood of using an insulin pump or continuous glucose monitor was lower for emerging adults (56 and 7%, respectively), and emerging adults were more likely to miss at least 1 insulin dose per day and have had an episode of diabetic ketoacidosis in the past year (3 and 7%, respectively).
The researchers found that during exercise and early recovery from exercise, plasma glucose increased slightly with MDG and decreased with control and insulin reduction, and there was a greater increase with glucose tablets.
Correlations with intensification were seen for better patient adherence before elevated HbA1c level, existing therapy with a second-generation antidiabetic drug, and lower doses of existing therapy. Patient factors explained 7.96% and 7.35% of the variation in initiation and intensification, respectively.
The NDA was supported by data from the Phase 3 inTandem clinical trial program which assessed the safety and efficacy of Zynquista in ~3000 adults with inadequately controlled type 1 diabetes.
The American Diabetes Association recommends against prolonged fasting for those with multiple complications of diabetes. Patients should measure glucose before, during, and after fasting, and should be aware of the signs and symptoms of low blood sugar.
"The addition of glucagon delivery to a closed-loop system with automated exercise detection reduces hypoglycemia in physically active adults with type 1 diabetes," the authors write.
Women with a history of gestational diabetes had significantly higher estimated glomerular filtration rate, even if they had not subsequently developed diabetes.
Higher BMI in lesbian and bisexual women is an important contributor to the greater level of type 2 diabetes among this population, the authors found.
The mean HbA1c was 5.67±0.66%. In the past year, only 2% of respondents reported diabetes-related hospitalizations, including 1% each for ketoacidosis and hypoglycemia.
Results showed there was a significant crude risk linked to continuing vs discontinuing certain antipsychotics and developing gestational diabetes; for quetiapine the risk was 7.1% vs 4.1% (adjusted relative risk [ARR] 1.28), respectively; among olanzapine users it was 12% vs 4.7% (ARR 1.61), respectively.