Diabetes

First CGM System With Implantable Glucose Sensor Approved

By June 22, 2018

The sensor is coated with a fluorescent chemical which produces a small amount of light when exposed to blood glucose.

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

June 22, 2018

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis

Dulaglutide Assessed in T2D Patients With Chronic Kidney Disease

By June 20, 2018

In AWARD-7, eligible patients (N=577) were randomized to receive dulaglutide 1.5mg once-weekly (N=193), dulaglutide 0.75mg (N=190) once-weekly, or insulin glargine daily (N=194), all in combination with insulin lispro, for 52 weeks. HbA1c at 26 weeks with a 0.4% non-inferiority margin was designated as the primary outcome, while secondary outcomes included eGFR and urine albumin-to-creatinine ratio.

HbA1c Targets Should Be Personalized in Type 2 Diabetes

June 20, 2018

In most patients with type 2 diabetes, the target should be an HbA1c level between 7 and 8%. For patients with type 2 diabetes and HbA1c levels <6.5%, deintensification of pharmacologic therapy should be considered.

Single Blood Sample Test May Help ID Undiagnosed Diabetes

June 20, 2018

Single-sample confirmatory definition associated with high positive predictive value

Cleared Blood Glucose Monitor Systems Not Always Accurate

June 19, 2018

"Cleared BGMs do not always meet the level of analytical accuracy currently required for regulatory clearance," the authors write.

Elevated NT-proBNP Found to Up Cardiovascular Risk in T2DM

June 15, 2018

NT-proBNP at baseline was independently linked to development of major CV events, in particular hospitalization for heart failure, after adjustment for potential confounders.

AMA: Federal Government Must Tackle Rising Insulin Prices

June 15, 2018

Currently, at least 5 states and a federal prosecutor are seeking information from insulin manufacturers and pharmacy benefit managers, and class action lawsuits have been filed on behalf of patients.

Diabetes Meds Reconciliation May Reduce Risk of ER Visits

June 14, 2018

The researchers found that 67.3, 10.6, and 22.1% of the 261,765 reconciliation assessment periods contributed by 31,689 patients had some, all, or none of the diabetes medications reconciled, respectively.

Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

By June 12, 2018

According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using this database.

Long-Term Type 1 Diabetes Associated With Cognitive Decline

June 12, 2018

Researchers compared cognition in 82 individuals with 50 or more years of type 1 diabetes (Medalists), 31 age-matched individuals with type 2 diabetes, and 30 age-matched control subjects without diabetes.

Better Dietary Patterns Among US Adults Could Save Billions

June 11, 2018

Cost savings were estimated at $66.9 and $135 billion, respectively, if the diet quality of US adults were to improve to achieve 80% of the maximum healthy eating index 2015 and mediterranean diet scores.

Erectile Dysfunction Independently Tied to CV Events

June 11, 2018

Participants with erectile dysfunction were more likely to have diabetes mellitus; a family history of CHD; and to use β-blocker, antihypertensive, lipid-lowering, and antidepressant medications.

Cancer Development Linked to Increased Diabetes Risk

June 11, 2018

In the first 2 years after cancer diagnosis, the excess risk for diabetes was highest, and it remained elevated throughout follow-up.

More Rapid Decline in Kidney Function for Diagnosed Diabetes

June 08, 2018

Much steeper decline in adjusted mean eGFR for those with diagnosed diabetes versus those without

Does Metformin Use Increase the Risk for Lactic Acidosis in T2D Patients?

By June 06, 2018

Results demonstrated an incidence rate of 391/100,000 person years was calculated based on the 163 patients who were hospitalized with lactic acidosis during the follow-up period.

FDA Clears Omnipod DASH System for Diabetes Management

By June 05, 2018

The Omnipod DASH system consists of a discreet, tubeless, waterproof Pod which is worn on the body, and the Personal Diabetes Manager (PDM), a handheld wireless device used to control the Pod.

Oral Semaglutide vs Empagliflozin for HbA1c: Efficacy Compared

June 01, 2018

Oral semaglutide 14mg led to statistically significant improvement in hemoglobin A1c levels and weight loss in adults with type 2 diabetes.

T1DM Self-Management Varies With Adult Developmental Stages

May 31, 2018

The likelihood of using an insulin pump or continuous glucose monitor was lower for emerging adults (56 and 7%, respectively), and emerging adults were more likely to miss at least 1 insulin dose per day and have had an episode of diabetic ketoacidosis in the past year (3 and 7%, respectively).

Mini-Dose Glucagon May Halt Post-Exercise Hypoglycemia

May 30, 2018

The researchers found that during exercise and early recovery from exercise, plasma glucose increased slightly with MDG and decreased with control and insulin reduction, and there was a greater increase with glucose tablets.

Elevated HbA1c Usually Leads to Prompt Tx Start, Intensification

May 30, 2018

Correlations with intensification were seen for better patient adherence before elevated HbA1c level, existing therapy with a second-generation antidiabetic drug, and lower doses of existing therapy. Patient factors explained 7.96% and 7.35% of the variation in initiation and intensification, respectively.

Oral T1D Treatment Zynquista to Be Reviewed by FDA

By May 22, 2018

The NDA was supported by data from the Phase 3 inTandem clinical trial program which assessed the safety and efficacy of Zynquista in ~3000 adults with inadequately controlled type 1 diabetes.

Hyperkalemia Treatment Lokelma Gets FDA Approval

By May 21, 2018

Lokelma is a non-absorbed zirconium silicate that preferentially captures potassium in exchange for hydrogen and sodium.

Semaglutide Found to Be Effective Against Type 2 Diabetes

May 21, 2018

The once-weekly glucagon-like peptide 1 receptor agonist cuts HbA1c, body weight

Pharmacists Should Counsel Patients Fasting for Ramadan

May 18, 2018

The American Diabetes Association recommends against prolonged fasting for those with multiple complications of diabetes. Patients should measure glucose before, during, and after fasting, and should be aware of the signs and symptoms of low blood sugar.

Dual-Hormone System May Lower Time in Hypoglycemia in T1DM

May 16, 2018

"The addition of glucagon delivery to a closed-loop system with automated exercise detection reduces hypoglycemia in physically active adults with type 1 diabetes," the authors write.

Gestational Diabetes May Indicate Future Subclinical Renal Issues

May 10, 2018

Women with a history of gestational diabetes had significantly higher estimated glomerular filtration rate, even if they had not subsequently developed diabetes.

Lesbian, Bi Women More Likely to Develop T2DM at Younger Age

May 09, 2018

Higher BMI in lesbian and bisexual women is an important contributor to the greater level of type 2 diabetes among this population, the authors found.

Exceptional Glycemic Control With Very Low-Carbohydrate Diet

May 09, 2018

The mean HbA1c was 5.67±0.66%. In the past year, only 2% of respondents reported diabetes-related hospitalizations, including 1% each for ketoacidosis and hypoglycemia.

Antipsychotic Use and Gestational Diabetes: Is There a Link?

By May 08, 2018

Results showed there was a significant crude risk linked to continuing vs discontinuing certain antipsychotics and developing gestational diabetes; for quetiapine the risk was 7.1% vs 4.1% (adjusted relative risk [ARR] 1.28), respectively; among olanzapine users it was 12% vs 4.7% (ARR 1.61), respectively.