Diabetes YIR 2017
The researchers found that while more cases than controls received at least 6 courses of antibiotics (17.9 versus 13.8%), the association between antibiotic use and risk of diabetes was progressively reduced when clinical and lifestyle factors were accounted for.
Multiple regression analyses revealed that fat intake, especially saturated fat intake, was significantly correlated with ΔHbA1c.
To determine the risk of T2DM, researchers compared adults with psoriasis (n=8124), grouping them by affected BSA, to those without psoriasis (n=76,599); patients were followed for ~4 years.
The data showed diabetes following pancreatic disease was more common than type 1 diabetes (2.59 [95% CI: 2.38-2.81] per 100,000 person-years vs. 1.64 [95% CI: 1.47-1.82]; P<0.001). These cases of diabetes following pancreatic disease (n=559) were primarily classified by clinicians as type 2 diabetes.
Researchers assessed incident diabetes by annual 75g oral glucose tolerance testing and semiannual fasting glucose among 3,234 participants enrolled in the Diabetes Prevention Program Outcomes Study.
In clinical trials, treatment with Bydureon BCise resulted in average HbA1c reductions of up to 1.4% and average weight loss of up to 3.1 pounds when used as monotherapy or as an add-on to metormin, a sulfonylurea, a thiazolidinedione, or any combination of two of these agents, at 28 weeks.
Researchers found an approximate 1% decrease in HbA1c with the addition of a sulfonylurea or metformin to insulin.
Study authors explained that using antibacterial mouthwash can eradicate oral microbes needed for nitric oxide formation and place the user at risk for metabolic disorders.
A trial (Dunn T et al. 2017) of ≥50,000 diabetes patients, that lasted 18 months, found that FreeStyle Libre users checked their glucose on average 16 times a day.
Study authors analyzed the occurrence of amputation in patients with type 2 diabetes mellitus treated with SGLT2 inhibitors vs. non-SGLT2 inhibitors, and specifically, canagliflozin.
The Food and Drug Administration (FDA) approval was based on data from the randomized, double-blind, placebo-controlled LEADER trial (n=9,340) that evaluated long-term effects of Victoza vs. placebo in patients with type 2 diabetes with high risk of major cardiovascular events (MACE).
A one-hour longer sleep duration correlated with 0.19 kg/m² lower body mass index, 0.03 kg/m5 lower fat mass index, 2.9% lower homeostasis model assessment of insulin resistance, and 0.24% lower fasting glucose.
The greatest incidence of bladder cancer was among the group who initiated pioglitazone treatment, in which there were 308 cases per 100,000 person-years.
Participants in the antimicrobial-dressing treatment arm experienced an additional 119 healing events. However, the researchers considered this "low-certainty evidence," due to risk of bias.
Faustman's team is preparing for a 5-year, 150-person Phase 2 trial to investigate the potential for repeat BCG vaccination to improve type 1 diabetes in adults with existing disease.
Since oxidative stress is known to worsen DKD, study authors sought to review available data on the possible benefits of chronic antioxidant supplementation on DKD progression.
Results showed that compared with current use of metformin + sulfonylurea, the use of thiazolidinediones + metformin was associated with an increased risk of CAP.
Both Synjardy and Synjardy XR should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. It carries a boxed warning regarding metformin-associated lactic acidosis.
The researchers identified an additional 24 published studies and 25 unpublished studies, since the last completed systematic review of 57 eligible studies.
The researchers found that, on average, age-adjusted diabetes incidence increased 0.314 per 1,000 per 1 degree Celsius increase in temperature.
Consumption of single omega-3 is associated with an increased risk of type 2 diabetes (T2D), with dosage, ethnicity, trial duration, and recruited age influencing the effect, according to a meta-analysis published online December 29 in the Journal of Diabetes Investigation.