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DEXEDRINE SPANSULE
ADHD
Sleep-wake disorders
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Drug Name:

DEXEDRINE SPANSULE CII

Generic Name and Formulations:
Dextroamphetamine sulfate 5mg, 10mg, 15mg; sust rel caps.

Company:
Amedra Pharmaceuticals



Therapeutic Use:

Indications for DEXEDRINE SPANSULE:

Attention deficit hyperactivity disorder.

Adult Dose for DEXEDRINE SPANSULE:

Not recommended.

Children's Dose for DEXEDRINE SPANSULE:

Individualize. <6yrs: not recommended. ≥6yrs: initially 5mg 1–2 times daily; may increase by 5mg/day at weekly intervals; usual max 40mg/day.

Pharmacological Class:

Amphetamine.

Contraindications:

Symptomatic cardiovascular disease. Moderate-to-severe hypertension. Advanced arteriosclerosis. Hyperthyroidism. Glaucoma. Agitated states. History of drug abuse. During or within 14 days of MAOIs. Hypersensitivity to sympathomimetics.

Warnings/Precautions:

High abuse potential. Structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease: not recommended. Hypertension. Heart failure. Recent MI. Arrhythmia. Assess cardiovascular status prior to treatment. Tourette's syndrome. Psychosis. Bipolar disorder. Consider discontinuation if emergence of new-onset psychotic or manic symptoms. Monitor for worsening of aggressive behavior or hostility. Seizure disorder; discontinue if occur. Peripheral vasculopathy, including Raynaud's Phenomenon; monitor for digital changes. Monitor growth, BP, HR, vision. Write ℞ for smallest practical amount. Reevaluate need for therapy after drug-free interval. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Hypertensive crisis with MAOIs. Potentiated by alkalinizers, MAOIs, propoxyphene (can cause convulsions), furazolidone. Potentiates tricyclic antidepressants, sympathomimetics, meperidine, norepinephrine, phenobarbital, phenytoin. Antagonized by acidifiers, chlorpromazine, haloperidol, lithium, methenamine. Antagonizes adrenergic blockers, ethosuximide, antihypertensives, sedating antihistamines, veratrum alkaloids. May interfere with urinary steroid tests.

Adverse Reactions:

Palpitations, hypertension, tachycardia, CNS overstimulation, dizziness, insomnia, headache, motor and phonic tics, dry mouth, unpleasant taste, diarrhea, constipation, anorexia, urticaria, impotence, priapism; visual disturbances, Tourette's syndrome.

How Supplied:

Caps—90

Indications for DEXEDRINE SPANSULE:

Narcolepsy.

Adult Dose for DEXEDRINE SPANSULE:

Individualize. 5–60mg daily in divided doses.

Children's Dose for DEXEDRINE SPANSULE:

Individualize. 6–12yrs: initially 5mg daily; may increase by 5mg/day at weekly intervals. ≥12yrs: initially 10mg daily; may increase by 10mg/day at weekly intervals.

Pharmacological Class:

Amphetamine.

Contraindications:

Symptomatic cardiovascular disease. Moderate-to-severe hypertension. Advanced arteriosclerosis. Hyperthyroidism. Glaucoma. Agitated states. History of drug abuse. During or within 14 days of MAOIs. Hypersensitivity to sympathomimetics.

Warnings/Precautions:

High abuse potential. Structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease: not recommended. Hypertension. Heart failure. Recent MI. Arrhythmia. Assess cardiovascular status prior to treatment. Tourette's syndrome. Psychosis. Bipolar disorder. Consider discontinuation if emergence of new-onset psychotic or manic symptoms. Monitor for worsening of aggressive behavior or hostility. Seizure disorder; discontinue if occur. Peripheral vasculopathy, including Raynaud's Phenomenon; monitor for digital changes. Monitor growth, BP, HR, vision. Write ℞ for smallest practical amount. Reevaluate need for therapy after drug-free interval. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Hypertensive crisis with MAOIs. Potentiated by alkalinizers, MAOIs, propoxyphene (can cause convulsions), furazolidone. Potentiates tricyclic antidepressants, sympathomimetics, meperidine, norepinephrine, phenobarbital, phenytoin. Antagonized by acidifiers, chlorpromazine, haloperidol, lithium, methenamine. Antagonizes adrenergic blockers, ethosuximide, antihypertensives, sedating antihistamines, veratrum alkaloids. May interfere with urinary steroid tests.

Adverse Reactions:

Palpitations, hypertension, tachycardia, CNS overstimulation, dizziness, insomnia, headache, motor and phonic tics, dry mouth, unpleasant taste, diarrhea, constipation, anorexia, urticaria, impotence, priapism; visual disturbances, Tourette's syndrome.

How Supplied:

Caps—90

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