Dermatological Disorders

Rituxan Granted Priority Review for Rare Autoimmune Disease

By February 16, 2018

The disease can be life threatening. Phase 3 study results released last March demonstrated Rituxan substantialy improved pemphigus vulgaris remission rates and successful tapering.

Oral JAK1 Inhibitor Gets Breakthrough Tx Designation for Atopic Dermatitis

By February 15, 2018

In December, a Phase 3, randomized, double-blind, placebo-controlled trial (JADE) was initiated to evaluate the safety and efficacy of PF-04965842 in 375 patients aged ≥12 years with moderate to severe AD.

FDA Accepts NDA for Plaque Psoriasis Treatment Jemdel

By February 14, 2018

Jemdel, if approved, will be the first high-potency topical steroid for plaque psoriasis with dosing for 8 weeks. The most common adverse event in clinical trials of Jemdel was upper respiratory tract infection.

Efficacy of Omalizumab for Refractory CSU Assessed in Real-World Settings

February 13, 2018

The remaining 3 patients had well-controlled disease after omalizumab treatment. In 30% of patients, the best response to omalizumab was achieved after interval administration of a 9-day course of methylprednisolone (total dose of 188mg)

Topical Nitrates Effective for Treating Raynaud's Phenomenon

By February 09, 2018

A total of 7 trials involving 346 patients were identified; nitroglycerin ointments were used in 4 trials, MQX-503 in 2 trials, and a compounded nitrite in 1 trial.

Acne Linked to Significantly Higher Risk of Major Depressive Disorder

February 09, 2018

The researchers found that the probability of developing MDD was 18.5 and 12% among patients with acne and in the general population without acne over the 15-year follow-up period.

Cosentyx Labeling Updated to Include Scalp Psoriasis Data

By February 08, 2018

Cosentyx is the first and only fully-human interleukin-17A (IL-17A) antagonist.

He Said, She Said: Clinician Sued After Patient Suffers Severe Drug Reaction

By February 07, 2018

It is essential to document warnings, especially significant ones, like this.

Stem Cell Transplant May Be Effective for Systemic Sclerosis

February 07, 2018

The researchers found that, over 7 years of follow-up, there was significant sustained improvement in skin score as well as in vasculopathy and gastrointestinal manifestations.

Tofacitinib + Phototherapy May Be Beneficial for Vitiligo Treatment

February 06, 2018

Case reports describe repigmentation of vitiligo with facial involvement in Hispanic woman, white man

Tentative Approval Granted for Generic Rosacea Cream

By January 30, 2018

Ivermectin cream is a semi-synthetic derivative isolated from the fermentation of Streptomyces avermitilis that belongs to the avermectin family of macrocyclic lactones.

Most Common Facial Implant Complications Investigated

January 24, 2018

The most common complications included infection, implant migration, swelling, and extrusion (46, 23, 18, and 10%, respectively).

Carboxytherapy vs. Platelet-Rich Plasma for Treating Stretch Marks

January 22, 2018

The fibronectin-stained area from skin biopsies was significantly higher in both groups after treatment compared with before, and it was significantly higher after carboxytherapy compared to PRP.

New Warnings Added to the Labeling for Kybella

By January 19, 2018

Cases of ulceration and necrosis have been reported with the administration of Kybella following injections that are too superficial.

Treatment of HCV Leads to Improvement in Patient's Psoriasis

January 17, 2018

The dose of topical agents and frequency of phototherapy were reduced and the Psoriasis Area and Severity Index score decreased to 2.0.

Combo Treatment Evaluated for Improving Neck Lines and Wrinkles

January 16, 2018

The researchers observed significant improvement in the mean neckline score, from 2.6 (moderate-to-severe lines) at baseline to 1.3 (mild lines) at 90 days after treatment.

Potential First-in-Class Treatment Fast-Tracked for Alopecia Areata

By January 12, 2018

Currently, there are no FDA approved treatments for alopecia areata.

Psoriasis and Comorbidity in Children: Are They Independently Linked?

January 11, 2018

The researchers found that compared to children without psoriasis, those with psoriasis were more likely to develop comorbidities.

Oral Acne Treatments

January 11, 2018

Oral medications for the treatment of acne including dosing for antibiotics, retinoids, and contraceptives.

Newborn Treated for Toxoplasmosis With Mother's SJS Causative Agents

By January 10, 2018

Stevens-Johnson syndrome is a severe skin reaction often triggered by certain medications.

Topical Acne Treatments

January 10, 2018

A chart of topical acne medications for the use in children and adults including available strengths.

Breast Implants Increase Rare Type of Lymphoma

January 05, 2018

"Our results emphasize the need for increased awareness among the public, medical professionals, and regulatory bodies; promotion of alternative cosmetic procedures; and alertness to signs and symptoms of breast-ALCL in women with implants," the authors write.

Methotrexate, Azathioprine Examined in Moderate-to-Severe Atopic Dermatitis

December 26, 2017

For up to five years as maintenance treatments for moderate-to-severe atopic dermatitis

FDA to Review Seysara for the Treatment of Moderate to Severe Acne

By December 26, 2017

Seysara (sarecycline) is a once-daily, oral, narrow spectrum tetracycline-derived antibiotic.

Injectable Fillers: Adverse Events and Associated Litigation Investigated

December 26, 2017

More serious adverse events include vascular compromise resulting in necrosis, blindness

Spironolactone/Minoxidil Combo Appears Effective for Female Pattern Hair Loss

December 20, 2017

There was an observed 0.85 mean reduction in hair loss severity score at 6 months and a 1.3 mean reduction at 12 months.

Long Term Antibiotic Use and Resistance Risk Assessed in Acne

December 18, 2017

The researchers found that resistant mutants with the 23S rRNA mutation were not isolated when P. acnes mutants were exposed to clarithromycin after being incubated in broth without antimicrobials.

Eskata Approved for Raised Seborrheic Keratoses

By December 15, 2017

The FDA approval was supported by two Phase 3 studies that demonstrated the safety and efficacy of Eskata for the treatment of raised seborrheic keratoses.

FDA Approves New Indication for Xeljanz, Xeljanz XR

By December 15, 2017

The new PsA approval was based on data from the Phase 3 OPAL Broaden, OPAL Beyond, and OPAL Balance studies.

Biosimilar Ixifi Gets FDA Approval for All Remicade Indications

By December 14, 2017

Ixifi is a chimeric human-murine monoclonal antibody (mAb) against tumor necrosis factor.