Dermatological Disorders

Sustained Use of Oxymetazoline Cream Efficacious for Rosacea

May 17, 2018

The researchers found that 8.2% of patients reported treatment-emergent adverse events (TEAEs), the most common were application site dermatitis, paresthesia, pain, and pruritus. Several authors disclosed financial ties to Allergan, which is a manufacturer of oxymetazoline.

Positive Results for Dupilumab in Teen Atopic Dermatitis Trial

By May 16, 2018

The primary endpoint was the proportion of patients with an IGA score of 0 (clear) or 1 (almost clear) at Week 16.

Topical Treatment for Epidermolysis Bullosa Gets FDA's Rare Pediatric Designation

By May 16, 2018

A previous Phase 2 trial of 17 patients with EBS showed that 60% of those treated with diacerein cream experienced at least a 40% reduction in blistering after 4 weeks vs 18% on vehicle.

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Causes, Treatment Investigated

By May 15, 2018

The multicenter retrospective study (N=377) was conducted to investigate the causes, treatment protocols, and mortality rates of US adults with SJS/TEN.

Can 3-D Printing Create Temporary Prosthesis, Cut Out Prosthodontist?

May 15, 2018

Evaluators were able to match the correct 3-D nose to the corresponding volunteers' photographs in 171 of 175 photographs (97.7%).

Shower Cream, Body Lotion Combo Improves Atopic Dry Skin

May 15, 2018

Both products reduced clinical dryness, roughness, redness, cracks, tingling, and itch, according to the dermatologist, and increased feelings of soothing, smoothness, and softness, according to the participants.

Teledermatology Could Expedite Care for Suspected Skin Cancer

May 14, 2018

The researchers found that the mean time to clinical resolution was 9 days with teledermoscopy referral, compared with 35 days with usual care alone.

Adverse Effect of Osteoporosis Drug May Help Treat Hair Loss

By May 11, 2018

Researchers found that a non-immunosuppressant drug originally designed to treat osteoporosis (WAY-316606) targeted the same mechanism by antagonizing SFRP1, and after treating hair follicles with WAY-316606 for 6 days, the authors found enhanced human hair growth.

Eskata Now Available to Treat Raised Seborrheic Keratoses

By May 07, 2018

Eskata is a high-concentration hydrogen peroxide-based topical solution intended for in-office application.

Combo Therapy Appears Safe, Effective for Severe Inflammatory Acne

By May 07, 2018

Treatment with the combination gel + oral doxycycline was associated with a 66.2% reduction in inflammatory lesions, a 58.7% reduction in non-inflammatory lesions, and a 62.6% reduction in total lesions at Week 12 vs baseline (P <.0001).

Psoriasis Negatively Affects Patient Sleep Quality

May 07, 2018

Based on the Pittsburgh Sleep Quality Index, 53.9% of patients with psoriasis were poor sleepers versus 21.9% of controls. Itch symptoms were significantly associated with all sleep-related outcomes.

HBV Reactivation Examined in Patients Treated With TNF Antagonists

By May 03, 2018

The authors examined data from 8887 individuals who began TNF antagonist treatment for an autoimmune disease from 2001 through 2010 and were followed through 2012; 52% of these patients were screened for HBV before treatment.

No Clinical Benefit Seen for Bath Emollients in Childhood Eczema

May 03, 2018

POEM scores didn't meet minimal clinically important difference after adjustment for confounders

Impoyz Cream Available to Treat Moderate to Severe Plaque Psoriasis

By May 01, 2018

The FDA approval was supported by data from 2 double-blind, randomized, vehicle-controlled trials (N=532) in patients with moderate to severe plaque psoriasis (IGA 3 or 4 and BSA ≥3%).

Hyaluronidase Can Remove Hyaluronic Acid Fillers in Cosmetic Dermatology

April 27, 2018

The researchers found that at 4 weeks and 4 months there were significant differences in physician rater assessment for visual detection and palpability between saline and hyaluronidase; this was mirrored by participant self-assessment at 4 weeks and 4 months.

Risankizumab BLA Submitted for Moderate to Severe Plaque Psoriasis

By April 25, 2018

The BLA is supported by data from the global risankizumab Phase 3 psoriasis program evaluating more than 2,000 patients.

Serlopitant Found to Be Safe, Effective for Chronic Pruritus

April 24, 2018

The decreases from baseline using visual analogue scale pruritus scores were statistically significantly larger with the 1- and 5-mg doses of serlopitant (P=.022 and .013, respectively) versus placebo at week 6.

Phone App Linked to Improved Psoriasis Treatment Adherence

April 23, 2018

The researchers found that at week 4, more patients in the intervention group were adherent to Cal/BD cutaneous foam versus patients in the non-intervention group (65 versus 38%: P=.004).

Birch Pollen-Related Foods Can Trigger Dermatitis Reactions

April 23, 2018

Of those with allergic reactions, 32 patients exhibited significant deterioration of AD. Compared to nonresponders, responders showed significantly higher specific immunoglobulin E (IgE) levels to birch pollen and apple in addition to a higher prevalence of allergic rhinoconjunctivitis.

Newly Designed Pulsed-Dye Laser Found Effective for Rosacea

April 20, 2018

The average improvement was 53.9%. Reported side effects included mild edema, mild-to-moderate erythema, and mild-to-moderate bruising.

Vaniqa Cream Currently in Shortage

By April 18, 2018

Vaniqa, a hair growth retardant, is indicated to reduce unwanted facial hair in women.

Endocrine Therapy-Induced Alopecia Seen in Breast Cancer

April 12, 2018

"Endocrine therapies are associated with a pattern alopecia similar to androgenetic-type, consistent with the mechanism of action of causal agents," the authors write.

Hyaluronic Acid Filler Feasible for Correcting Infraorbital Hollows

April 09, 2018

The average time to additional treatment was 35.7 days. Adverse effects included bruising, contour irregularities, swelling, and Tyndall effect, and these occurred in 10, 2, 3, and 1% of patients, respectively.

U.S. Providers Fix Complications From Medical Tourism Procedures

April 09, 2018

The researchers found that among 78 identified patients over a 7-year period, complications were seen following abdominoplasty (35 procedures), breast augmentation (25), and foreign body injections (15).

Oral Acne Treatments

April 05, 2018

Oral medications for the treatment of acne including dosing for antibiotics, retinoids, and contraceptives.

Microneedling &#43; 5-Fluorouracil Effective Vitiligo Treatment

March 23, 2018

The researchers found that overall repigmentation was significantly higher in the patches treated with 5-fluorouracil compared with tacrolimus. Excellent improvement was seen in 48% of the 5-fluorouracil-treated patches versus 16% of tacrolimus-treated patches.

Ilumya Approved for Moderate-to-Severe Plaque Psoriasis

By March 21, 2018

The FDA approval of Ilumya for the treatment of adults with moderate-to-severe plaque psoriasis was supported by data from the pivotal Phase-3 reSURFACE clinical development program.

Updated Practice Guideline on Hirsutism Management Issued

March 15, 2018

"Excess facial or body hair is not only distressing to women, it is often a symptom of an underlying medical problem," said Kathryn Martin, MD, Massachusetts General Hospital and lead author of the study.

High Prevalence of Sunburn in U.S. Highlights Need for Targeted Prevention

March 15, 2018

The researchers found that 34.2% of participants experienced sunburn in 2015. The prevalence was higher among younger age groups (51.2% for those aged 18 to 29 years) and in non-Hispanic whites and those with sun-sensitive skin (42.5 and 50.2%, respectively).

Botulinum Toxin Injections After Surgery May Improve Facial Scars

March 09, 2018

The researchers found that, based on the 14 patients who completed the study, the visual analogue scale score and scar width measurements showed a significant improvement in appearance and narrower scars for the halves of the scars treated with botulinum toxin type A (P=0.046 and 0.001, respectively).