DEPODUR
Generic Name for DEPODUR
Morphine sulfate 10mg/mL; ext-rel liposomal susp for epidural inj; preservative free.
Legal Classification:
CII
Pharmacological Class for DEPODUR
Opioid.
Manufacturer of DEPODUR
EKR Therapeutics. Inc.
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Indications for DEPODUR
Post-op pain after major surgery.
Adult dose for DEPODUR
≥18yrs: Give as a single dose by lumbar epidural inj only, before surgery or after clamping umbilical cord in caesarean section. Individualize. Monitor closely for at least 48 hrs after dosing. Orthopedic surgery (lower extremities): 15mg. Lower abdominal or pelvic surgery: 10–15mg. Caesarean section: 10mg. All: max 20mg.
Children's dosing for DEPODUR
<18 yrs: not recommended.
Contraindications for DEPODUR
Head injury. Increased intracranial pressure. Respiratory depression. Asthma. Upper airway obstruction. Paralytic ileus. Circulatory shock.
Warnings/Precautions for DEPODUR
Conditions that increase risk of respiratory depression (eg, hypercapnia, obesity, surgery cancellation). Impaired myocardial function. Volume depletion. Biliary tract disease. Acute pancreatitis. Seizure disorders. GI or GU obstruction. Drug abusers. Elderly. Debilitated. Labor & delivery (not for use in vaginal delivery). Pregnancy (Cat.C). Nursing mothers.
Interactions for DEPODUR
During or within 14 days of MAOIs: not recommended. Epidural local anesthetics: allow ≥15 minutes between test dose of lidocaine and epinephrine and DepoDur inj; allow ≥30 minutes between analgesic dose of bupivacaine and Depodur inj. Suspend use of other epidural drugs for at least 48 hrs. Potentiated by other CNS depressants (eg, alcohol, other opiates, general anesthetics, sedatives, antihistamines, phenothiazines). Potentiates neuromuscular blockers.
Adverse Reactions for DEPODUR
CNS and respiratory depression, orthostatic hypotension, urinary retention, GI upset, constipation, paralytic ileus, pruritus, pyrexia, anemia, headache, dizziness, biliary colic, bladder spasm, bradycardia, tachycardia, back pain.
Notes for DEPODUR
Be fully experienced in the administration of epidural drugs. Have resuscitative equipment and narcotic antagonists immediately available.
How is DEPODUR supplied?
Single-use vials (1mL, 1.5mL)—5
Related Disease:
Pain, general~narcotics