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DDAVP NASAL SPRAY
Pituitary disorders
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Drug Name:

DDAVP NASAL SPRAY Rx

Generic Name and Formulations:
Desmopressin acetate 10mcg/spray; nasal spray; contains benzalkonium chloride.

Company:
Ferring Pharmaceuticals, Inc.



Therapeutic Use:

Indications for DDAVP NASAL SPRAY:

Central (cranial) diabetes insipidus. Temporary polyuria and polydipsia following head trauma or surgery in the pituitary region.

Adult Dose for DDAVP NASAL SPRAY:

10–40mcg daily intranasally in 1–3 divided doses; usually 20mcg in two divided doses. Use rhinal tube for doses <10mcg or doses other than multiples of 10mcg.

Children's Dose for DDAVP NASAL SPRAY:

<3months: not recommended. ≥3months: 5–30mcg daily intranasally in 1–2 divided doses. Use rhinal tube for doses <10mcg or doses other than multiples of 10mcg.

See Also:

DDAVP

DDAVP INJECTION

DDAVP RHINAL TUBE

Pharmacological Class:

Vasopressin (synthetic).

Contraindications:

Moderate to severe renal impairment (CrCl <50mL/min). Hyponatremia, or history of.

Warnings/Precautions:

Monitor fluid intake, urine volume and osmolality. Fluid/electrolyte imbalance (eg, cystic fibrosis). Habitual or psychogenic polydipsia. Coronary artery insufficiency. Hypertension. Inj: Predisposition to thrombosis. Nasal mucosal changes (nasal forms). Young children. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Caution with other pressor agents, drugs that may increase the risk of water intoxication with hyponatremia (eg, tricyclic antidepressants, SSRIs, chlorpromazine, opiates, NSAIDs, lamotrigine, carbamazepine). Possible convulsions with oxybutynin, imipramine.

Adverse Reactions:

Headache, nausea, flushing, abdominal cramps, vulval pain, water intoxication, hyponatremia, nasal congestion or rhinitis (nasal forms), inj site reaction; rare: changes in BP, severe allergic reactions, seizures in children from plasma hypoosmolality, thrombotic events (inj).

How Supplied:

Tabs—100; Nasal spray—5mL (50 sprays); Rhinal tube—2.5mL (w. 2 rhinal tubes); Amp (1mL)—10; Multi-dose vial (10mL)—1

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