DALIRESP Rx

Select the drug indication to add to your list

DALIRESP

Asthma/COPD
Only 4 drugs may be compared at once

Generic Name and Formulations:

Roflumilast 500mcg; tabs.

Select therapeutic use:

Indications for DALIRESP:

To reduce risk of COPD exacerbations in severe COPD patients with chronic bronchitis and a history of exacerbations.

Limitations Of use:

Not for the relief of acute bronchospasm.

Adult:

500mcg once daily.

Children:

Not established.

Contraindications:

Moderate-to-severe liver impairment (Child-Pugh Class B or C).

Warnings/Precautions:

Depression. Suicidal ideation. Mild liver impairment (Child-Pugh Class A). Monitor for insomnia, anxiety, depression, suicidal ideation, other mood changes; reevaluate if occurs. Monitor weight regularly; consider discontinuing if unexplained or significant weight loss occurs. Pregnancy (Cat.C). Labor & delivery, nursing mothers: not recommended.

Interactions:

Concomitant strong CYP450 inducers (eg, rifampicin, phenobarbital, carbamazepine, phenytoin): not recommended. Potentiated by CYP3A4 and CYP1A2 inhibitors (eg, erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine), and by oral contraceptives containing gestodene + ethinyl estradiol (possible increased adverse effects).

Pharmacological Class:

Selective phosphodiesterase 4 (PDE4) inhibitor.

Adverse Reactions:

Diarrhea, weight loss, nausea, headache, back pain, influenza, dizziness, decreased appetite; psychiatric effects (eg, insomnia, anxiety, depression).

How Supplied:

Tabs—30, 90

DALIRESP 500mcg tablets (Qty:30)

appx. price $337.00