DAILY DOSE THRESHOLDS FOR ANTIPSYCHOTICS
 
Generic Brand
(Manufacturer)
Usual Maximum
Oral Daily Dose
Maximum Daily Dose to Manage
Behavioral Symptoms Related to
Dementing Illnesses
FIRST GENERATION
chlorpromazine (various) 800mg  75mg
fluphenazine (various)  40mg   4mg
haloperidol (various) 100mg   2mg
loxapine Loxitane
(Watson)
250mg  10mg
perphenazine (various)  64mg   8mg
pimozide Orap
(Gate)
 10mg   *
prochlorperazine (various) 150mg   *
thioridazine (various) 800mg  75mg
thiothixene Navane
(Pfizer)
 60mg   7mg
trifluoperazine (various)  40mg   8mg
ATYPICAL ANTIPSYCHOTICS
aripiprazole Abilify
(BMS & Otsuka)
 30mg  10mg
asenapine Saphris
(Merck)
 20mg   *
clozapine Clozaril
(Novartis)
900mg  50mg
iloperidone Fanapt
(Novartis)
 24mg   *
olanzapine Zyprexa
(Lilly)
 20mg 7.5mg
paliperidone Invega
(Janssen)
 12mg   *
quetiapine Seroquel
(AstraZeneca)
800mg 150mg
risperidone Risperdal
(Janssen)
 16mg   2mg
ziprasidone Geodon
(Pfizer)
160mg   *
NOTES

* Not customarily used for the treatment of behavioral symptoms.
Adapted from the CMS State Operations Manual: Appendix PP - Guidance to Surveyors for Long Term Care Facilities.
Available at: cms.hhs.gov/manuals/Downloads/som107ap_pp_guidelines_ltcf.pdf. Accessed 9/2010.

(Rev. 2/2012)