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COVERA-HS
Angina
Hypertension
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Drug Name:

COVERA-HS Rx

Generic Name and Formulations:
Verapamil HCl 180mg, 240mg; controlled-onset ext-rel tabs.

Company:
Pfizer Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for COVERA-HS:

Angina.

Adult Dose for COVERA-HS:

Swallow whole once daily at bedtime. ≥18yrs: initially 180mg; may titrate upwards in steps to 240mg, then 360mg, then 480mg if necessary.

Children's Dose for COVERA-HS:

<18yrs: not recommended.

Pharmacological Class:

Calcium channel blocker (diphenylalkylamine).

Contraindications:

Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree heart block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract.

Warnings/Precautions:

Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. GI narrowing. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium.

Adverse Reactions:

Hypotension, constipation, upper respiratory infection, dizziness, fatigue, GI upset, AV block, bradycardia, paresthesia, elevated liver enzymes, paralytic ileus.

How Supplied:

Tabs—100

Indications for COVERA-HS:

Hypertension.

Adult Dose for COVERA-HS:

Swallow whole once daily at bedtime. ≥18yrs: initially 180mg; may titrate upwards in steps to 240mg, then 360mg, then 480mg if necessary.

Children's Dose for COVERA-HS:

<18yrs: not recommended.

Pharmacological Class:

Calcium channel blocker (diphenylalkylamine).

Contraindications:

Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree heart block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract.

Warnings/Precautions:

Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. GI narrowing. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium.

Adverse Reactions:

Hypotension, constipation, upper respiratory infection, dizziness, fatigue, GI upset, AV block, bradycardia, paresthesia, elevated liver enzymes, paralytic ileus.

How Supplied:

Tabs—100