COSMEGEN Rx

Select the drug indication to add to your list

COSMEGEN

Bladder, kidney, and other urologic cancers
Bone and connective tissue cancer
Gynecologic cancers
Prostate and other male cancers
Only 4 drugs may be compared at once

Generic Name and Formulations:

Dactinomycin 500mcg/vial; lyophilized pwd for IV inj or regional perfusion after reconstitution; contains mannitol; preservative-free.

Select therapeutic use:

Indications for COSMEGEN:

In combination with other chemotherapy and/or multi-modality treatment regimen for Wilms' tumor. As a component of regional perfusion, for palliative and/or adjunctive treatment of locally recurrent or locoregional solid malignancies.

Adult:

Give by IV infusion. Wilms' tumor: 15mcg/kg daily for 5 days. Regional perfusion: 50mcg/kg for lower extremity or pelvis; 35mcg/kg for upper extremity. Max 15mcg/kg/day per 2-week cycle or 400–600mcg/m2/day for five days. Use surface area to calculate dose for obese or edematous patients.

Children:

See literature.

Contraindications:

Current or recent chickenpox or herpes zoster.

Warnings/Precautions:

Myelosuppression; monitor bone marrow and hold treatment if platelets or WBCs decrease markedly. Extremely corrosive; avoid extravasation. Avoid skin, mucous membranes, eyes. Previous irradiation (esp. within 2 months of irradiation for treatment of right-sided Wilms' tumor), cytotoxic chemotherapy. Monitor renal and hepatic function. Obese. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Avoid live vaccines. Concomitant radiotherapy in Wilms' tumor: not recommended.

Pharmacological Class:

Actinomycin antibiotic.

Adverse Reactions:

GI upset, stomatitis, bone marrow suppression (neutropenia, thrombocytopenia), liver toxicity, infusion site reactions, malaise, fatigue, alopecia, possible second primary tumors (including leukemia); for perfusion therapy: infection, impaired wound healing, superficial ulceration of gastric mucosa, edema, soft tissue damage, possible venous thrombosis.

How Supplied:

Vials—1

COSMEGEN 1ml of 0.5mg vials (Qty:1)

appx. price $1431.00

Indications for COSMEGEN:

In combination with other chemotherapy and/or multi-modality treatment regimen for childhood rhabdomyosarcoma, Ewing's sarcoma. As a component of regional perfusion, for palliative and/or adjunctive treatment of locally recurrent or locoregional solid malignancies.

Adult:

Give by IV infusion. Childhood rhabdomyosarcoma, Ewing's sarcoma: 15mcg/kg daily for 5 days. Regional perfusion: 50mcg/kg for lower extremity or pelvis; 35mcg/kg for upper extremity. Max 15mcg/kg/day per 2-week cycle or 400–600mcg/m2/day for five days. Use surface area to calculate dose for obese or edematous patients.

Children:

See literature.

Contraindications:

Current or recent chickenpox or herpes zoster.

Warnings/Precautions:

Myelosuppression; monitor bone marrow and hold treatment if platelets or WBCs decrease markedly. Extremely corrosive; avoid extravasation. Avoid skin, mucous membranes, eyes. Previous irradiation (esp. within 2 months of irradiation for treatment of right-sided Wilms' tumor), cytotoxic chemotherapy. Monitor renal and hepatic function. Obese. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Avoid live vaccines. Concomitant radiotherapy in Wilms' tumor: not recommended.

Pharmacological Class:

Actinomycin antibiotic.

Adverse Reactions:

GI upset, stomatitis, bone marrow suppression (neutropenia, thrombocytopenia), liver toxicity, infusion site reactions, malaise, fatigue, alopecia, possible second primary tumors (including leukemia); for perfusion therapy: infection, impaired wound healing, superficial ulceration of gastric mucosa, edema, soft tissue damage, possible venous thrombosis.

How Supplied:

Vials—1

COSMEGEN 1ml of 0.5mg vials (Qty:1)

appx. price $1431.00

Indications for COSMEGEN:

Gestational trophoblastic neoplasia.

Adult:

Give by IV infusion. 12mcg/kg daily for 5 days as a single agent; 500mcg on Days 1 and 2 as combination regimen with etoposide, methotrexate, folinic acid, vincristine, cyclophosphamide, and cisplatin. Max 15mcg/kg/day per 2-week cycle or 400–600mcg/m2/day for five days. Use surface area to calculate dose for obese or edematous patients.

Children:

See literature.

Contraindications:

Current or recent chickenpox or herpes zoster.

Warnings/Precautions:

Myelosuppression; monitor bone marrow and hold treatment if platelets or WBCs decrease markedly. Extremely corrosive; avoid extravasation. Avoid skin, mucous membranes, eyes. Previous irradiation (esp. within 2 months of irradiation for treatment of right-sided Wilms' tumor), cytotoxic chemotherapy. Monitor renal and hepatic function. Obese. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Avoid live vaccines. Concomitant radiotherapy in Wilms' tumor: not recommended.

Pharmacological Class:

Actinomycin antibiotic.

Adverse Reactions:

GI upset, stomatitis, bone marrow suppression (neutropenia, thrombocytopenia), liver toxicity, infusion site reactions, malaise, fatigue, alopecia, possible second primary tumors (including leukemia); for perfusion therapy: infection, impaired wound healing, superficial ulceration of gastric mucosa, edema, soft tissue damage, possible venous thrombosis.

How Supplied:

Vials—1

COSMEGEN 1ml of 0.5mg vials (Qty:1)

appx. price $1431.00

Indications for COSMEGEN:

In combination with other chemotherapy and/or multi-modality treatment regimen for metastatic, nonseminomatous testicular cancer. As a component of regional perfusion, for palliative and/or adjunctive treatment of locally recurrent or locoregional solid malignancies.

Adult:

Give by IV infusion. Metastatic nonseminomatous testicular cancer (in combination with cyclophosphamide, bleomycin, vinblastine, and cisplatin): 1000mcg/m2 on Day 1. Regional perfusion: 50mcg/kg for lower extremity or pelvis; 35mcg/kg for upper extremity. Max 15mcg/kg/day per 2-week cycle or 400–600mcg/m2/day for five days. Use surface area to calculate dose for obese or edematous patients.

Children:

See literature.

Contraindications:

Current or recent chickenpox or herpes zoster.

Warnings/Precautions:

Myelosuppression; monitor bone marrow and hold treatment if platelets or WBCs decrease markedly. Extremely corrosive; avoid extravasation. Avoid skin, mucous membranes, eyes. Previous irradiation (esp. within 2 months of irradiation for treatment of right-sided Wilms' tumor), cytotoxic chemotherapy. Monitor renal and hepatic function. Obese. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Avoid live vaccines. Concomitant radiotherapy in Wilms' tumor: not recommended.

Pharmacological Class:

Actinomycin antibiotic.

Adverse Reactions:

GI upset, stomatitis, bone marrow suppression (neutropenia, thrombocytopenia), liver toxicity, infusion site reactions, malaise, fatigue, alopecia, possible second primary tumors (including leukemia); for perfusion therapy: infection, impaired wound healing, superficial ulceration of gastric mucosa, edema, soft tissue damage, possible venous thrombosis.

How Supplied:

Vials—1

COSMEGEN 1ml of 0.5mg vials (Qty:1)

appx. price $1431.00