COMBIVIR
Generic Name for COMBIVIR
Lamivudine 150mg, zidovudine 300mg; tabs.
Legal Classification:
Rx
Pharmacological Class for COMBIVIR
Nucleoside analogues (reverse transcriptase inhibitors).
Manufacturer of COMBIVIR
GlaxoSmithKline Pharmaceuticals
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Indications for COMBIVIR
HIV infection.
Adult dose for COMBIVIR
1 tab twice daily. Hepatic or renal dysfunction (CrCl <50mL/min): not recommended.
Children's dosing for COMBIVIR
Not recommended.
Warnings/Precautions for COMBIVIR
Bone marrow depression. Anemia. Not for use with other lamivudine or zidovudine products. Hepatitis B (monitor for post-treatment exacerbation). Decompensated liver disease or risk factors for liver disease. Suspend if lactic acidosis or hepatotoxicity (e.g., hepatomegaly, steatosis) occurs. Women, obesity, prolonged nucleoside exposure: increased risk of toxicity. Monitor blood counts. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for COMBIVIR
See literature. Avoid concomitant other forms of zalcitabine, stavudine, doxorubicin, ribavirin. Bone marrow suppression increased by ganciclovir, interferon-alpha, cytotoxic drugs. TMP/SMX, atovaquone, fluconazole, methadone, probenecid, valproic acid, possibly others may affect lamivudine or zidovudine blood levels (clinical significance unknown); monitor. Triple therapy (once daily regimen) with abacavir + tenofovir or with didanosine + tenofovir: high rate of early viral non-response (see literature). Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.
Adverse Reactions for COMBIVIR
Headache, GI upset, malaise, fatigue, nasal symptoms, cough, musculoskeletal pain, neuropathy, insomnia, fever/chills, dizziness, depression, rash, myalgia, arthralgia, lab abnormalities (neutropenia, severe anemia, thrombocytopenia, elevated ALT/AST, bilirubin or amylase), hyperglycemia, seizures, lactic acidosis, severe hepatomegaly with steatosis, fat redistribution, myopathy; pancreatitis (rare).
Notes for COMBIVIR
Register pregnant patients exposed to lamivudine by calling (800) 258-4263.
How is COMBIVIR supplied?
Tabs—60
Related Disease:
HIV~antivirals