Colorectal Disorders

Biosimilar Ixifi Gets FDA Approval for All Remicade Indications

By December 14, 2017

Ixifi is a chimeric human-murine monoclonal antibody (mAb) against tumor necrosis factor.

Sanofi Discontinues <i>C. Difficile</i> Tx Development

By December 08, 2017

Data that has been collected from the trial so far will be analyzed and shared with the scientific community in due time.

Safety and Efficacy of Switching Infliximab to Biosimilar in IBD

By December 06, 2017

Results showed that disease activity scores before and after switching were not statistically significantly different (Crohn's disease activity index: P=.5657 and Truelove-Witts disease activity index: P=.7609).

Polyethylene Glycol vs. Pulsed Irrigation Evacuation for Colon Prep

December 06, 2017

The researchers found that PIE and sodium phosphate were superior to PEG, with both receiving a score of 4 on a 5-point scale (blind assessment), versus a 3 for PEG (P<0.01).

Pediatric Ulcerative Colitis Tx Granted Orphan Drug Status

By December 04, 2017

The designation is based on a review of Phase 1b clinical data which showed potential for SER-287 as a novel treatment modality for patients with UC

IV Iron Sucrose Evaluated for Iron Deficiency Anemia in Pediatric IBD

By December 01, 2017

Results of the review also found that 18 adverse events occurred in a total of 13 patients (18.1% of patients; 6.6% of infusions).

Fecal Microbial Transplant via Oral Capsule Versus Colonoscopy

November 29, 2017

The researchers found that prevention of recurrent CDI after a single treatment was achieved by 96.2% of participants in the capsule and colonoscopy groups in the per-protocol analysis (difference, 0%), meeting the criterion for noninferiority.

Fish Consumption May Trigger Food Protein-Induced Enterocolitis

October 31, 2017

The number of reactions before diagnosis was four on average. The main symptoms at the debut were vomiting and vomiting with diarrhea (97.5 and 30%, respectively), which occurred in a mean time of 126.3 minutes after ingestion of the culprit fish.

Orphan Drug Status Granted to Tx for Rare Bowel Disorder

By October 25, 2017

A Phase 2 trial demonstrated how glepaglutide treatment was associated with reduced fecal wet weight output as well as indicated increases in energy, fluid and electrolyte absorption.

Does Breastfeeding Protect Against Future Inflammatory Bowel Conditions?

By October 25, 2017

The researchers found that ever being breastfed was associated with a lower risk of CD and UC (OR 0.71, 95% CI 0.59-0.85 and OR 0.78, 95% CI 0.67-0.91 respectively).

Treatment for Fistulizing Crohn's Disease Gets Orphan Drug Status

By October 24, 2017

Cx601 is a first-in-class allogeneic cell therapy intended for patients who have had an inadequate response to at least one conventional or biologic therapy.

Treating Iron Deficiency Anemia in Patients With Inflammatory Bowl Disorder

By October 19, 2017

Despite its frequency, iron deficiency anemia in patients with IBD it is often overlooked in clinical settings.

Mesalamine Formulation Switch Linked to Acute Renal Failure in UC Patient

By October 17, 2017

The 35-year-old male from Hawaii maintained clinical remission with Lialda, a once-daily formulation of mesalamine, and infliximab.

Same-Day vs. Split Dose Bowel Prep for Colonoscopy Compared

By October 16, 2017

Results showed that adenoma detection rate (ADR) did not differ between groups. Additionally willingness to repeat and tolerability did not differ.

New Therapeutic Drug Monitoring Test for Ustekinumab Announced

By October 16, 2017

By measuring drug and antibody concentrations physicians can adapt treatment strategies and guide patients toward more personalized medicine.

Noninvasive Test Monitors Healing Status in Crohn's Disease Patients

By October 16, 2017

The PROMETHEUS Monitr Crohn's Disease test can be used as an adjunct to endoscopy or by itself between endoscopies.

Impact of Early Azathioprine Use on Crohn's Disease Progression Evaluated

October 02, 2017

Prior bowel resection, smoking, and low hemoglobin tied to Crohn's-related surgery

Hair Regrowth in Alopecia Patients After Fecal Transplant for Recurrent CDI

By September 22, 2017

These 2 cases suggests that fecal transplants can have a profound immunological response not only limited to intestinal effects, say the authros.

Does Prenatal Biologic Therapy for IBD Affect Infant Vaccine Response?

By September 18, 2017

In addition, the researchers assayed umbilical cord blood samples from 33 infants to assess the concentration of biologic agents.

Higher Incidence of GI Symptoms in Female IBS Patients on Clopidogrel

By September 11, 2017

The results showed a higher proportion of patients with GI symptoms on clopidogrel (68%) compared to controls (60%, P=0.0011) that were Females (70% vs. 60%, P=0.0003) not Males (61 vs. 60%; P=0.8312).

Pediatric Ulcerative Colitis Tx Granted Orphan Drug Designation

By September 08, 2017

Early Phase 1 data has indicated that the treatment drug can be more efficacious than mesalamine/5-ASA treatments alone.

FDA Reveals Stem Cell Policy Plans Amid Clinic Crackdowns

By August 28, 2017

An FDA inspection of the clinic found that adipose tissue was being processed into stromal vascular fraction (stem cells derived from body fat) which was then administered intravenously or directly into the spinal cord of patients.

Biosimilar Cyltezo Gets FDA Approval for Multiple Indications

By August 28, 2017

This marks the second approval of a biosimilar for adalimumab.

Model May Predict Colectomy Likelihood at First Colitis Episode

August 21, 2017

At index admission, 11% of patients underwent colectomy, and 26% had one over a median follow-up of 56 months.

AGA: Recommendations for Monitoring Drug Therapy in IBD

By August 14, 2017

To optimize drug concentration and improve outcomes, therapeutic drug monitoring is used to check the trough concentration and evaluate for the presence of anti-drug antibodies.

Mytesi Granted Orphan Drug Designation for Short Bowel Syndrome

By August 07, 2017

Clinical studies of Mytesi have shown that the most common adverse reactions were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough, and flatulence (3.1%).

Biosimilar Renflexis Now Available

July 24, 2017

Infliximab products work by neutralizing the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibiting the binding of TNF-alpha with its receptors.

Diagnosing and Treating Exocrine Pancreatic Insufficiency

By July 17, 2017

A recent opinion piece by Struyvenberg et al. aims to address the existing myths, remove the current confusion, and function as a practical guide to the diagnosis and treatment of EPI.

How Common Is EPI in Patients with Chronic Abdominal Pain, Diarrhea?

By July 17, 2017

Overall, pancreatic exocrine insufficiency was identified in 10 patients (4.6%; 95% CI 2.2-8.3%) with five patients having severe pancreatic exocrine insufficiency (2.3%; 95% CI 0.8-5.3%).

Value of Enhanced Recovery Protocol in Colon, Rectal Sx

July 11, 2017

Based on one retrospective review of 8 years of compliance, the strongest predictors of shorter length of stay were identified as no nasogastric tube, early mobilization, early oral nutrition, early removal of epidural and urinary catheter, and nonopioid analgesia.