Colorectal Disorders

Model May Predict Colectomy Likelihood at First Colitis Episode

August 21, 2017

At index admission, 11% of patients underwent colectomy, and 26% had one over a median follow-up of 56 months.

AGA: Recommendations for Monitoring Drug Therapy in IBD

By August 14, 2017

To optimize drug concentration and improve outcomes, therapeutic drug monitoring is used to check the trough concentration and evaluate for the presence of anti-drug antibodies.

Mytesi Granted Orphan Drug Designation for Short Bowel Syndrome

By August 07, 2017

Clinical studies of Mytesi have shown that the most common adverse reactions were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough, and flatulence (3.1%).

Biosimilar Renflexis Now Available

July 24, 2017

Infliximab products work by neutralizing the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibiting the binding of TNF-alpha with its receptors.

Diagnosing and Treating Exocrine Pancreatic Insufficiency

By July 17, 2017

A recent opinion piece by Struyvenberg et al. aims to address the existing myths, remove the current confusion, and function as a practical guide to the diagnosis and treatment of EPI.

How Common Is EPI in Patients with Chronic Abdominal Pain, Diarrhea?

By July 17, 2017

Overall, pancreatic exocrine insufficiency was identified in 10 patients (4.6%; 95% CI 2.2-8.3%) with five patients having severe pancreatic exocrine insufficiency (2.3%; 95% CI 0.8-5.3%).

Value of Enhanced Recovery Protocol in Colon, Rectal Sx

July 11, 2017

Based on one retrospective review of 8 years of compliance, the strongest predictors of shorter length of stay were identified as no nasogastric tube, early mobilization, early oral nutrition, early removal of epidural and urinary catheter, and nonopioid analgesia.

No Signs of Abuse Potential with Eluxadoline in IBS-D

July 10, 2017

The researchers found that there was no significant difference between the groups in terms of adverse events potentially related to abuse (2.8, 2.7, and 4.3%, respectively, for those given placebo, eluxadoline 75mg, or eluxadoline 100mg)

Task Force Issues New CRC Screening Recommendations

By June 21, 2017

Individuals with a family history of CRC in a first-degree relative diagnosed before age 60 should undergo colonoscopy every 5 years beginning at age 40 or 10 years before the age at which their relative was diagnosed.

Extent of Microbial Repopulation Examined Following Fecal Transplant

June 19, 2017

In 2 of the patients, some donor microbe strains persisted as long as 2 years after a transplant. In 5 others, donor strains persisted for 3 to 6 months, according to the University of Alabama at Birmingham researchers.

Uceris Evaluated in Mesalamine-Refractory Ulcerative Colitis

By May 18, 2017

At Week 8, combined clinical and endoscopic remission was obtained in 13.0% of budesonide MMX patients vs. 7.5% of placebo patients.

Tenapanor Achieves Primary Endpoint in IBS-C Trial

By May 12, 2017

Results showed that the endpoint was met with 27% in the tenapanor arm compared to 18.7% in the placebo arm (P=0.02) having at least 30% reduction in abdominal pain and an increase of 1 or more complete spontaneous bowel movements.

Managing Abdominal Pain in IBD: A Review

By May 09, 2017

Researchers analyzed 13 intervention studies which evaluated various psychological, dietary, and drug interventions.

Tofacitinib Effective for Moderate-to-Severe Ulcerative Colitis

May 04, 2017

A total of 18.5% patients taking tofacitinib experienced a remission of their condition in 8 weeks compared to just 8.2% of patients receiving placebo.

New Therapeutic Option for Crohn's Disease Looks Promising

May 03, 2017

Five of seven patients from pilot study were in deep remission at six-month follow-up

Biosimilar Renflexis Gets FDA Approval

By April 21, 2017

A biosimilar product must demonstrate no clinically meaningful differences in safety or efficacy from the reference product.

CDC Analyze Hospitalization Rates for Crohn's Disease in Last Decade

April 14, 2017

Stable trends for a first-listed Crohn's disease diagnosis from 2003 to 2013 suggest that the previous annual increase has not continued.

Does IBD Impact Response to Booster Pertussis Dose?

By April 12, 2017

The data showed no difference in the rates of adequate vaccine response between the 4 study groups (P=0.11). Patients with IBD taking immunosuppressive therapy did not differ from those not taking immunosuppressive therapy (90.6% vs. 88.2%; P=0.37).

Risankizumab for Moderate-to-Severe Crohn's Disease

By April 12, 2017

Feagan, BG et al. "Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn's disease: a randomised, double-blind, placebo-controlled phase 2 study"

IBS Relief Launched for Digestive Support, Symptom Relief

By April 11, 2017

IBS Relief from Accord is available as a 60-count bottle. It can be purchased online or in stores nationwide.

Colorectal Risks ID'd With Consistent Antibiotic Use in Middle-Age

April 06, 2017

The researchers found that the use of antibiotics within the previous 4 years wasn't associated with a heightened risk of colorectal adenomas, but long-term use in the past was.

Synergy Seeks IBS-C Indication for Trulance

By March 28, 2017

The new application for an IBS-C indication is supported by data from two placebo-controlled Phase 3 studies that lasted 12 weeks and evaluated plecanatide in 2,100 patients with IBS-C.

Refractory Ulcerative Colitis in a Patient with NSAID Hypersensitivity

By March 22, 2017

The patient, a 33-year old woman with a history of drug hypersensitivity to NSAIDs and aspirin, presented for management of her chronic UC with mesalamine.

FDA: IBS Drug Linked to Pancreatitis in Certain Patients

By March 15, 2017

Since its approval in May 2015 through February 2017, the FDA has received 120 reports of serious cases of pancreatitis or death.

Is Drug Therapy Effective for Recurrent Abdominal Pain in Children?

By March 07, 2017

In this study, researchers aimed to determine how effective these pharmacological interventions are in school-aged children with recurrent abdominal pain (RAP).

Ustekinumab Effective for Long-Term Remission in Crohn's Disease

By February 17, 2017

Among randomized patients who entered the long-term extension trial period , 79.2% of patients receiving ustekinumab every 12 weeks and 87.1% of patients receiving ustekinumab every 8 weeks were in remission,

Safety, Efficacy of Fecal Transplant for <i>C. difficile</i> During Pregnancy

February 10, 2017

A fecal microbiota transplant through colonoscopy appears to be safe for recurrent Clostridium difficile infection during pregnancy, according to a case report published in the March issue of Obstetrics and Gynecology.

Five Items ID'd to Reduce SSI Rate in Colon Surgery

February 07, 2017

Implementation of a bundle of five items can reduce the surgical site infection (SSI) rate in colon surgery, according to a study published online February 1 in the Journal of Evaluation in Clinical Practice.

Amneal Launches Generic Lotronex

By January 31, 2017

Amneal has launched Alosetron HCl Tablets, the generic equivalent to Prometheus' Lotronex.

Certain Fatty Acids Linked to Ulcerative Colitis Flare

By January 23, 2017

For patients with ulcerative colitis (UC) being treated with aminosalicylates, high dietary intake of certain fatty acids may increase the risk of flare.