Colorectal And Other GI Cancers

Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

May 16, 2018

Per 10,000 person-years of observation, the incidence rates of CRC were 20, 9.1, and 7.5 for advanced adenoma, non-advanced adenoma, and no adenoma, respectively.

Potentially Inappropriate Med Use Prevalent in Cancer Patients

April 27, 2018

Overall, 37.5% of patients with breast cancer had at least one adverse outcome; correlations included use of at least 5 medications, advanced stage, higher comorbidity, and previous emergency room visits/hospitalizations

Sigmoidoscopy reduces colon cancer risk for men, but not women

April 24, 2018

Sigmoidoscopy was associated with a reduction in the prevalence of colon cancer mortality in men.

Flexible Sigmoidoscopy Cuts CRC Incidence, Mortality in Men

April 24, 2018

The researchers found that the absolute risks for CRC were 1.86 and 2.05% in the screening and control groups, respectively, among women and were 1.72 and 2.50% in men.

BEACON CRC Safety Lead-in Study suggests safety and efficacy of triplet combo Tx metastatic colorectal CA

April 13, 2018

BEACON CRC is a multicenter, randomized, phase 3 clinical trial evaluating the triplet combination of binimetinib (BINI, a MEK inhibitor) + encorafenib (ENCO, a BRAF inhibitor) + cetuximab (CETUX, an EGFR antibody) for the treatment of metastatic colorectal cancer.

Iron Formulation and Cancer Risk: Is There a Link?

By April 12, 2018

In the U.S., ferric citrate is commonly found in dietary supplements and ferric EDTA is often used as a food additive.

Increased Prevalence of Depression, Anxiety After CRC

April 12, 2018

Less anxiety and depression were seen in association with being married; a lower educational level and comorbid conditions were correlated with more anxiety and depression.

Positive Top-Line Results for Ramucirumab in HCC Announced

By April 04, 2018

REACH-2 was a randomized, double-blind, placebo-controlled trial that enrolled 292 patients with hepatocellular carcinoma (HCC) who were intolerant to, or had disease progression while on or following treatment with sorafenib and had a high alpha-fetoprotein (AFP-High) defined as AFP ≥400ng/mL.

Three, Six Month Adjuvant CAPOX Equally Effective for Colon Cancer

March 30, 2018

The researchers identified 3,263 events of disease recurrence or death in 12,834 patients; in the overall study population, the noninferiority of 3 months versus 6 months of treatment was not confirmed.

Reduced Overall Survival for Alcohol-Related Liver Cancer

March 28, 2018

When survival was assessed at each Barcelona Clinic Liver Cancer (BCLC) stage, the prognostic role of alcohol disappeared. Increased lead time-adjusted median OS was seen for patients with HCC detected during a cirrhosis follow-up program (199 patients) compared to those with HCC diagnosed incidentally.

BMI Linked to Hepatocellular Carcinoma Risk in Chronic Hep B

March 26, 2018

The researchers found that there were 11,241 HCCs in men and 3,368 in women during the 8 years of follow-up. In both men and women, the risk of HCC was positively associated with BMI in a dose-response manner.

Long-Term Effects of Eradicating <i>H. Pylori</i> Examined for Gastric Cancer Risk

March 22, 2018

For the 327 patients who underwent histologic analysis, improvement in the atrophy grade at the gastric corpus lesser curvature from baseline was observed in 48.4% of the patients in the treatment group and in 15% of those in the placebo group.

FDA Fast Tracks Pedmark for Prevention of Cisplatin-Induced Ototoxicity

By March 21, 2018

The Clinical Oncology Group Protocol ACCL0431 trial enrolled 125 pediatric patients newly diagnosed with a germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, osteosarcoma, or other malignancy.

Cabometyx sNDA for Hepatocellular Carcinoma Indication Submitted to FDA

By March 15, 2018

CELESTIAL is a randomized, double-blind, placebo-controlled study of cabozantinib in patients with advanced HCC conducted at more than 100 sites globally in 19 countries.

Colonoscopy significantly reduces mortality from colorectal cancer in Veterans Affairs study

March 14, 2018

Colonoscopy in veterans was associated with reduced mortality from both left and right-sided colorectal cancer.

iPad app that allows patients to order tests doubles colon cancer screening rates in study

March 13, 2018

Digital health intervention resulted in significantly higher colon cancer screening rates among participants.

FDA Approves New Dosing Option for Opdivo

By March 06, 2018

This approval will provide healthcare professionals the flexibility to customize patient care.

Calcium, Vit. D Supplementation Linked to Increased Risk of Serrated Polyps

March 02, 2018

Late effect findings of sessile serrated adenomas, polyps in those taking calcium with/without vitamin D

Lower Cancer Recurrence May Be Linked to Higher Nut Intake

March 01, 2018

After a median follow-up of 6.5 years, the researchers found that individuals who consumed 2 or more servings of nuts per week had adjusted hazard ratios of 0.58 for disease-free survival and 0.43 for overall survival.

Lutathera Approved for Gastroenteropancreatic Neuroendocrine Tumors

By January 26, 2018

Lutathera is a radiolabeled somatostatin analog indicated for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut, and hindgut neuroendocrine tumors in adults.

Periodontitis in Older Adults Tied to Higher Total Cancer Risk

January 24, 2018

During a median follow-up of 14.7 years, the researchers identified 1,648 incident cancers and 547 cancer deaths.

Proinflammatory Diets May Up the Risk of Colorectal Cancer

January 19, 2018

Higher empirical dietary inflammatory pattern score linked to increased risk of CRC for men and women

Blood Test Shows Promise for Early Colorectal Cancer Detection

January 17, 2018

Liquid biopsy that identifies circulating tumor cells in a blood sample has high accuracy for detecting colorectal cancer.

Do Pre-Op Cholesterol Levels Impact Post-Op Pain Outcomes?

December 13, 2017

The researchers observed a weak, but significant, positive correlation between total cholesterol and numeric rating scale scores on post operative days 0 and 1.

FDA Approves Second Biosimilar for the Treatment of Cancer

By December 01, 2017

Ogivri is the first biosimilar approved in the U.S. for the treatment of breast cancer or stomach cancer and the second biosimilar approved in the U.S. for the treatment of cancer.

FDA Approves InSure One to Aid in Detecting Lower GI Bleeding

By November 13, 2017

The InSure ONE requires a sample of water from the toilet bowl, after the stool surface has been brushed to release any blood.

PPI Use May Up Gastric Cancer Risk Even After <i>H. Pylori</i> Eradication Tx

November 02, 2017

Results showed that PPI use correlated with elevated risk of GC (hazard ratio, 2.44; 95% confidence interval, 1.42 to 4.2), while histamine-2 receptor antagonist use was not associated with increased risk (hazard ratio, 0.72; 95% confidence interval, 0.48 to 1.07).

Long-Term Aspirin Use Linked to Reduced Incidence of GI Cancers

By October 31, 2017

Researchers compared patients who were prescribed aspirin over a long period (for at least six months, average duration of aspirin prescribed was 7.7 years) with non-aspirin users and assessed the incidences of a number of cancers.

HCV Treatment With DAAs Reduces Liver Cancer Risk Significantly

By October 20, 2017

Study authors from the University of Washington, Seattle, and Veterans Affairs Puget Sound Healthcare System in Seattle sought to investigate whether HCV eradication with DAAs could lower the risk of liver cancer in patients.

Aspirin May Aid in Preventing Liver Cancer in Hep B Patients

October 20, 2017

The researchers found that the cumulative incidence of HCC in the treated group was significantly lower than that in the untreated group in five years.