Colorectal And Other GI Cancers

Opdivo Approved to Treat MSI-H or dMMR Metastatic Colorectal Cancer

By August 01, 2017

In the Phase 2, multicenter, open-label, single-arm CheckMate -142 trial (n=74), qualified patients received Opdivo 3mg/kg intravenously (IV) every 2 weeks.

Updated Prescribing Information for ChiRhoStim

By July 25, 2017

ChiRhoStim is available as 16mcg and 40mcg strength lyophilized powder in single-dose vials for reconstitution.

FDA Committee in Favor of Herceptin Biosimilar Approval

By July 14, 2017

Herceptin, a human epidermal growth factor receptor (HER2) inhibitor, is currently approved to treat HER2-overexpressing metastatic breast cancer as a single agent in patients who have received one or more chemotherapy regimens; or in combination with paclitaxel in patients who have not received chemotherapy.

Vectibix Approved as First-Line Tx for Wild-Type <i>RAS</i> mCRC

By June 30, 2017

In addition, the FDA has also approved a multigene, next-generation sequencing-based test to identify RAS mutation status of the patient's tumor and help physicians identify patients who will more likely benefit from Vectibix.

Task Force Issues New CRC Screening Recommendations

By June 21, 2017

Individuals with a family history of CRC in a first-degree relative diagnosed before age 60 should undergo colonoscopy every 5 years beginning at age 40 or 10 years before the age at which their relative was diagnosed.

NSAID Use May Benefit Certain Colorectal Cancer Survivors

June 20, 2017

The researchers administered detailed epidemiologic questionnaires to 2,419 patients age 18 to 74 years with incident invasive CRC, diagnosed from 1997 to 2008.

Gifts From Drug Manufacturers Influence Clinician's Rx Choices

June 07, 2017

Doctors were 78% more likely to prescribe a drug to treat metastatic renal cell carcinoma if they'd received a gift or small payment from that drug's manufacturer, compared to physicians who didn't receive any payments.

FDA to Review Opdivo for Hepatocellular Carcinoma Indication

By June 02, 2017

The sBLA submission was based on results from the Phase 1/2 CheckMate -040 study.

FDA Grants Unique Approval for Cancer Drug Keytruda

By May 24, 2017

Keytruda, a programmed death receptor-1 (PD-1)-blocking antibody, recently gained approval for urothelial carcinoma and metastatic non-small cell lung cancer (NSCLC).

Distinction Between Cancer Occurrence in U.S.-, African-Born Blacks

April 14, 2017

Research suggests differences in environmental, cultural, social, genetic factors

Opdivo Granted Priority Review for Colorectal Cancer Indication

By April 06, 2017

Opdivo, a human programmed death receptor-1 (PD-1)-blocking antibody, is already indicated for various renal and urologic cancers, head and neck cancer, lymphoma, skin cancer, and lung cancer.

Colorectal Risks ID'd With Consistent Antibiotic Use in Middle-Age

April 06, 2017

The researchers found that the use of antibiotics within the previous 4 years wasn't associated with a heightened risk of colorectal adenomas, but long-term use in the past was.

Researchers ID Possible Biomarker in Rectal CA Outcomes

April 04, 2017

The researchers observed a significant decrease of E-cadherin expression and a significant increased single-cell growth at the invasion front in tumor samples after radiochemotherapy versus primary biopsies of the tumor.

Are Antiemetic Prophylactics Being Overprescribed for Chemotherapy?

By March 24, 2017

Study authors identified a total of 8,545 patients undergoing 73,577 administrations of chemotherapy with minimal or low emetic risk.

Risks Following RFA for Liver Cancer in ESRD Patients on Hemodialysis Investigated

March 20, 2017

Dialyzed patients have higher in-hospital mortality, hemorrhagic complications after RFA for HCC

CDC: Cancer Screening 'Considerably' Below Targets

March 07, 2017

The researchers found that screening test use remained considerably below HP2020 targets for selected cancer screening tests.

Are Fewer Americans Over 50 Dying From Colorectal Cancer?

March 02, 2017

Colorectal cancer (CRC) rates among those aged 50 and older have fallen 32% since 2000, while deaths from the disease fell by 34%, according to a report published online March 1 in CA: A Cancer Journal for Clinicians.

Breath Test to Detect GI Cancers Shows Promise

February 03, 2017

Test could reduce the number of unnecessary endoscopies, researcher says

Is Chemo Overused for Younger Colon Cancer Patients?

January 26, 2017

Young and middle-aged colon cancer patients may be getting chemotherapy more often than is warranted, according to a study published online in JAMA Surgery.

Encouraging Results for Lenvatinib in HCC Trial

By January 25, 2017

Eisai has announced positive topline results from their Phase 3 trial of lenvatinib (Lenvima), for the first-line treatment of patients with unresectable hepatocellular carcinoma (HCC).

CIMP Outcome Prediction Ability After Colorectal CA Surgery

January 19, 2017

For patients undergoing colorectal cancer (CRC) surgery, CpG island methylator phenotype (CIMP) status predicts survival, according to research published online Jan. 14 in the Journal of Gastroenterology and Hepatology.

Does Participation in Meaningful Use Impact Quality of Care?

January 04, 2017

Improvement in colorectal cancer screening but not in other quality of care metrics

NSAIDs and Aspirin Compared for Colorectal Cancer Prevention

By December 20, 2016

The efficacy of NSAIDs, aspirin, and supplements in preventing the recurrence of advanced neoplasia after polyp removal was evaluated in a new study.

Statins Linked to Reduced Risk of Advanced Colorectal Adenoma

November 30, 2016

In meta-analysis, statin use linked to reduced risk of advanced, but not any colorectal adenoma

Guidelines Developed for HER2 Testing in Gastroesophageal Cancer

November 15, 2016

Tumor specimens should be assessed for HER2 status before initiation of HER2-targeted therapy

Adjuvant PegIFN/RBV Ups Survival in HCV/HCC Patients Receiving TACE

By November 13, 2016

In patients with chronic hepatitis C virus (HCV) infection and intermediate stage hepatocellular carcinoma (HCC) who receive transarterial chemoembolization (TACE), the SVR achieved with pegylated-interferon (pegIFN/ribavirin (RBV) treatment markedly improved survival and reduced tumor recurrence, a study presented at The Liver Meeting 2016® concluded.

Regorafenib Inhibits Sorafenib-Resistant HCC Cell Growth

By November 12, 2016

Regorafenib shows potential utility as a second-line treatment for patients with sorafenib-resistant HCC.

First Oral Pentamidine Isethionate Safe, Well Tolerated for Early Stage HCC

By November 12, 2016

The investigational oral pentamidine isethionate formulation VLX103 is safe and well tolerated at the once-daily 300mg to 900 mg dose.

Colon Capsule Endoscopy Accurate in Polyp Detection

November 01, 2016

Second-generation CCE has high sensitivity and specificity for polyps 6 mm and 10 mm

Serious Comorbities Remain a Risk for HIV Patients on ART

October 28, 2016

For patients taking antiretroviral medications, HIV continues to reside in tissues, and though this may not cause AIDS, it could contribute to the development of unrelated conditions such as cancer and cardiovascular disease, according to research published in the October issue of the Journal of Virology.