Induction of ovulation.
50mg daily for 5 days beginning on the 5th day of menstrual cycle; max 3 courses. If ovulation does not occur after 1st course, increase dose to 100mg daily for 2nd course; max 100mg/day for 5 days. See full labeling.
Primary ovarian failure. Ovarian cysts. Uterine leiomyomas. Abnormal vaginal bleeding. Thrombophlebitis. Liver disease. Depression. Uncontrolled thyroid or adrenal dysfunction. Organic intracranial lesions (eg, pituitary tumor). Pregnancy (Cat.X).
Perform initial complete pelvic and endocrinologic exam. If ovarian enlargement occurs, hold dose until ovaries return to pretreatment size, and reduce dosage or duration of next course. Polycystic ovary syndrome. Discontinue if visual disorders occur. Nursing mothers.
Ovarian enlargement, abdominal pain and bloating, blurred vision, hot flashes, breast discomfort, depression, multiple births, ocular toxicity.