Select therapeutic use:
Indications for CLINORIL:
Rheumatoid arthritis. Osteoarthritis. Ankylosing spondylitis. Acute painful shoulder. Acute gouty arthritis.
Take with food. 150mg twice daily; max 400mg/day. Acute painful shoulder or gouty arthritis: 200mg twice daily, usually for 7–14 days.
Aspirin allergy. Coronary artery bypass graft surgery.
Advanced renal disease: not recommended. Active or history of GI bleeding, peptic ulcer, or kidney stones. Heart failure. Impaired renal or hepatic function. Edema. Hypertension. Bleeding disorders. Sepsis. Diabetes. Preexisting asthma. Maintain adequate hydration. Monitor blood, hepatic, renal, and ocular function in chronic use. Discontinue if unexplained fever, pancreatitis, or liver dysfunction occurs. Systemic lupus erythematosus and mixed connective tissue disease. Elderly. Debilitated. Pregnancy (Cat.C); avoid in late pregnancy. Nursing mothers: not recommended.
Increased risk of GI toxicity with aspirin, other NSAIDs, alcohol, smoking. Probenecid increases serum levels. Diflunisal reduces serum levels. Antagonized by, and peripheral neuropathy with, DMSO. Monitor anticoagulants, antihyperglycemics. Caution with methotrexate, cyclosporine, nephrotoxic drugs (increased toxicity). Increased serum lithium levels (monitor). May antagonize diuretics, ACE inhibitors, angiotensin II antagonists (monitor).
NSAID (indene deriv.).
GI ulcer/bleeding/pain, dyspepsia, nausea, diarrhea, constipation, rash (discontinue if occurs), dizziness, headache, tinnitus, edema, nephritis, nephrotic syndrome, pancreatitis, jaundice, hepatitis. See literature re: risk of cardiovascular events.