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CLIMARA
Menopause and HRT
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Drug Name:

CLIMARA Rx

Generic Name and Formulations:
Estradiol 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.06mg/day, 0.075mg/day, 0.1mg/day; transdermal patch.

Company:
Bayer Healthcare Pharmaceuticals Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

Indications for CLIMARA:

Moderate to severe vasomotor symptoms of menopause. Vulvar or vaginal atrophy. Postmenopausal osteoporosis prevention. Hypoestrogenism.

Adult Dose for CLIMARA:

Apply 1 patch once weekly to lower abdomen or upper buttock (avoid breasts, waistline); rotate application sites. Hypoestrogenism: see literature. Other uses: initially one 0.025mg/day patch. Give cyclically (3 weeks on, 1 week off). Reevaluate periodically. Postmenopausal osteoporosis: supplement diet with calcium 1.5g/day.

Children's Dose for CLIMARA:

Not applicable.

Pharmacological Class:

Estrogen.

Contraindications:

Undiagnosed abnormal genital bleeding. Thromboembolic disorders. Thrombophlebitis. Breast or estrogen-dependent carcinoma. Pregnancy (Cat.X).

Warnings/Precautions:

Patients with intact uterus should almost always receive a progestin to avoid endometrial hyperplasia. Familial hyperlipoproteinemia or history of breast cancer. Hepatic insufficiency. Conditions aggravated by fluid retention. Endometriosis. Gallbladder disease. Bone disease associated with hypercalcemia. Do initial complete physical and repeat annually (include Pap smear, mammogram, and BP). Discontinue if hypertension or jaundice occurs and during immobilization, or at least 2 weeks before surgery associated with increased risk of thromboembolism. Nursing mothers.

Adverse Reactions:

See literature. Local irritation, fluid retention, breakthrough bleeding, mastodynia, nausea, abdominal cramps, headache, migraine, dizziness, intolerance to contact lenses.

How Supplied:

Patches—4

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