Select therapeutic use:
Indications for CLEOCIN:
Serious susceptible infections where less toxic antibiotics are inappropriate, including respiratory, skin and soft tissue, septicemia, intraabdominal, female pelvic or genital; bone and joint (inj).
Take with full glass of water. Serious: 150–300mg every 6hrs. More severe: 300–450mg every 6hrs. Beta-hemolytic streptococcal infections: treat for at least 10 days.
Take with full glass of water. Serious: 8–16mg/kg per day. More severe: 16–20mg/kg per day. Divide into 3–4 equal doses. Beta-hemolytic streptococcal infections: treat for at least 10 days.
Not for treatment of meningitis. Discontinue if colitis occurs and treat. Permanently discontinue if severe skin reactions occur. Allergy. Asthma (75mg, 150mg caps). GI disease (esp. colitis). Atopy. Monitor blood, renal, and hepatic function in long-term use and in children. IV: Gasping syndrome (neonates, infants). Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
May potentiate neuromuscular blocking agents. May antagonize erythromycin; avoid. Antiperistaltic agents may worsen colitis.
Pseudomembranous colitis, C. difficile-associated diarrhea, nausea, vomiting, abdominal pain, dysguesia, rash, anaphylaxis, jaundice, renal dysfunction, blood dyscrasias, polyarthritis, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome).
Caps—100; Granules (100mL)—1; Inj (2mL, 4mL, 6mL vials)—25