Serious susceptible infections where less toxic antibiotics are inappropriate, including respiratory, skin and soft tissue, septicemia, intraabdominal, female pelvic or genital; bone and joint (inj).
Take with full glass water. Serious: 150–300mg every 6 hours. More severe: 300–450mg every 6 hours.
Take with full glass water. Serious: 8–16mg/kg per day. More severe: 16–20mg/kg per day. Divide into 3–4 equal doses.
Not for treatment of meningitis. Discontinue if colitis occurs and treat. Monitor neonates. Allergy. Asthma (75mg, 150mg caps). GI disease (esp. colitis). Monitor blood, renal, and hepatic function in long-term use and in children. Renal or hepatic disease with metabolic aberrations. Pregnancy (Cat.B). Nursing mothers.
May potentiate neuromuscular blocking agents. May antagonize erythromycin. Antiperistaltic agents may worsen colitis.
Pseudomembranous colitis, diarrhea, GI upset, rash, anaphylaxis, jaundice, renal dysfunction, blood dyscrasias, polyarthritis.
Caps 75mg—100; 150mg, 300mg—16, 100; Granules (100mL)—1; Inj (2mL, 4mL vials)—25