Cladribine Rx

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Leukemias, lymphomas, and other hematologic cancers
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Generic Name and Formulations:

Cladribine 1mg/mL; soln for IV infusion after dilution; preservative-free.

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Indications for Cladribine:

Active hairy cell leukemia.


Give by continuous IV infusion for 7 consecutive days. 0.09mg/kg per day.


See full labeling.

Boxed Warning:

Administer under the supervision of a qualified physician experienced in the use of antineoplastic therapy. Risk of neurological toxicity. Acute nephrotoxicity has been observed with high doses (esp. when concomitant with other nephrotoxic treatments).


Delay or discontinue if neurotoxicity or renal toxicity occurs. Myelosuppression. Active infection. Renal or hepatic insufficiency. Monitor blood counts (esp. during first 4–8 weeks post-dose), renal and hepatic function. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Chlorinated purine nucleoside analog.


Live attenuated vaccines: not recommended. Increased toxicity with myelosuppressive, immunosuppressive, or nephrotoxic agents.

Adverse Reactions:

Severe myelosuppression (eg, neutropenia, anemia, thrombocytopenia), fever, infection, fatigue, nausea, rash, headache, inj site reactions, others; neurotoxicity, nephrotoxicity, tumor lysis syndrome (rare).



Generic Availability:


How Supplied:

Contact supplier.