Chlorothiazide Rx

Indications for Chlorothiazide:

Edema.

Adult Dose for Chlorothiazide:

Initially 0.5g–1g once or twice daily, every other day, or 3–5 days/wk.

Children's Dose for Chlorothiazide:

<6 months: up to 15mg/lb per day in 2 divided doses. ≥6 months: 10mg/lb per day in 2 divided doses.

Pharmacological Class:

Thiazide.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K⁺-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Contact supplier.

Indications for Chlorothiazide:

Hypertension.

Adult Dose for Chlorothiazide:

0.5–1g/day as single or divided doses; max 2g/day.

Children's Dose for Chlorothiazide:

<6 months: up to 15mg/lb per day in 2 divided doses. ≥6 months: 10mg/lb per day in 2 divided doses.

Pharmacological Class:

Diuretic (thiazide).

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K⁺-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Contact supplier.