CHF And Arrhythmias

Hemodynamic markers of pulmonary hypertension in HFpEF are associated with mortality

March 19, 2018

Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is common in patients undergoing a right heart catheterization.

Low Sperm Count Associated With Worse Cardiometabolic Health

March 19, 2018

Low sperm counts linked to hypogonadism, higher BMI, hypertension, dyslipidemia, metabolic syndrome

Generic Clopidogrel Compared to Plavix for Seniors With Acute Coronary Syndrome

March 19, 2018

The researchers found that the primary outcome was experienced by 17.6% of patients prescribed Plavix and 17.9% prescribed clopidogrel at 1 year (hazard ratio, 1.02; 95% confidence interval, 0.96 to 1.08; P=0.005 for noninferiority).

Pulmonary Hypertension in HFpEF: Outcomes Examined in Patients With Heart Catheterization

March 16, 2018

Cardiac hospitalizations occurred in 28.1 and 47.4% at 1 and 5 years, respectively. Using clinically defined cut-offs for transpulmonary gradient (>12mm Hg), pulmonary vascular resistance (3 Woods units), and diastolic pulmonary gradient (≥7mm Hg), the frequency of precapillary PH was 12.6, 8.8, and 3.5%, respectively.

Genetic Heart Diseases May Cause Less Cases of SIDS Than Previously Thought

March 15, 2018

The researchers found that 53 SIDS cases (12.6%) had at least 1 "potentially informative" GHD-associated variant. For mixed-European ancestry cases, the yield was 14.9% (21 of 141), and for European ancestry SIDS cases it was 11.5% (32 of 278).

Study Examines Hazard of Mortality for A-Fib Patients Receiving Digoxin

March 15, 2018

However, compared with patients not on digoxin, patients with a serum digoxin concentration ≥1.2 ng/mL had a 56% increased hazard of mortality (adjusted HR, 1.56; 95% confidence interval, 1.2 to 2.04). For each 0.5-ng/mL increase (P=0.001), there was a 19% higher adjusted hazard for death, and these results were similar in patients with and without heart failure.

Intensive blood pressure control not linked to changes in cerebral perfusion in cerebral small vessel disease

March 14, 2018

In patients with severe cerebral small vessel disease, a strategy of intensive blood pressure control did not significantly alter whole brain blood flow when compared to standard blood pressure control.

Centrifugal-Flow Pump Compared With Axial-Flow Pump in Advanced HF

March 13, 2018

Magnetically levitated centrifugal-flow pump beats mechanical bearing axial-flow pump at two years

Novel Inhaled Tx Found to Be Ineffective for Patients With Heart Failure

By March 13, 2018

The trial enrolled 105 patients who had HFpEF causing shortness of breath and fatigue with ordinary or mild physical activity.

Canagliflozin Cuts Hospitalization Risk for HF in Type 2 Diabetes Patients

By March 12, 2018

The results showed canagliflozin was associated with a significant reduction in risk of CV death or HHF by 22%.

Use of Carvedilol for Anthracycline Cardiotoxicity Prevention Investigated

March 12, 2018

Carvedilol does not prevent reduction in LVEF in breast cancer but is linked to lower troponin I levels

Febuxostat Linked to Increased Death Risk in Gout Patients With Heart Disease

March 12, 2018

Participants were followed for a median of 32 months.

Link Between FGF23 Concentrations and Heart Disease Examined

March 09, 2018

After adjustment for established CHD risk factors and kidney function, higher FGF23 concentrations were correlated with increased risk of CHD (hazard ratio comparing fourth with first quartile, 2.15).

Pharmacists Playing Key Role in Cardiac Management, Report Finds

March 09, 2018

"It's important for a patient to understand their meds, as well as to understand why lifestyle issues, such as diet and exercise are important," Mary Curtis, PharmD, from Bremo Pharmacy, said in a statement.

FDA Approves Smallest Ever Mechanical Heart Valve

By March 07, 2018

Findings from a single-arm study (N=20) of pediatric patients with serious heart failure (aged 1.5 weeks to 27 months) at the time of mitral valve implant were reviewed by the Agency. Study data showed a 69.3% probability of survival post-implant and a 66.8% probability of not experiencing a valve-related adverse event.

Ready-to-Use Esmolol HCl in Water for Injection Available

By March 01, 2018

Esmolol will be available in two presentations—ready-to-use Esmolol HCl In Water for Injection 2500mg/250mL and ready-to-use Esmolol HCl DOUBLE STRENGTH In Water for Injection 2000mg/100mL.

Vegetation size >10mm associated with increased risk of mortality in infective endocarditis

February 28, 2018

In this systematic review and meta-analysis, patients with infective endocardititis with vegetations greater than 10mm in size had significantly increased risk of systemic embolism and mortality.

Sex Specific Relationship Between Obesity and Myocardial Infarction Examined

February 28, 2018

During 7 years of follow-up, the researchers identified 5,710 cases of MI among 265,988 women and 213,622 men without a history of cardiovascular disease at baseline. In both sexes, there was an approximate log-linear relationship between measures of general and central adiposity and the risk of MI.

Combo LABA/LAMA Therapy Improves Cardiac Function in COPD

By February 23, 2018

Results demonstrated that after indacaterol-glycopyrronium treatment, left-ventricular end-diastolic volume increased from a mean 55.46mL/m2 (SD 15.89) at baseline to a least-squares (LS) mean of 61.76mL/m2 (95% CI 57.68-65.84).

Aspirin comparable to rivaroxaban for extended venous thromboembolism prophylaxis following arthroplasty

February 23, 2018

Patients initially treated with rivaroxaban following total knee or hip arthroplasty experienced similar rates of venous thromboembolism (VTE) regardless of continued rivaroxaban use or switching to aspirin for extended VTE prophylaxis.

Performance of Second Generation Stents Tested, Compared for LMCAD

February 23, 2018

In between-group comparisons of the different DES, the adjusted hazard ratios for target-vessel failure were similar, except for the PtCr-EES versus the BP-BES (reference, hazard ratio, 1.6; 95% confidence interval, 1.01 to 2.54; P=0.046) in multiple treatment propensity score analysis.

Sudden Cardiac Arrest, Ventricular Arrhythmia Risk Examined With Sulfonylureas

By February 16, 2018

Using U.S. Medicaid claims (1999-2010) from 5 states, the researchers sought to examine the association between individual sulfonylureas (glyburide, glimepiride, glipizide) and outpatient-originating SCA/VA; glipizide exposure was considered the reference exposure.

Systolic Blood Pressure and HFpEF Outcomes: What's the Link?

February 15, 2018

Increased risk of heart failure readmission at 30 days; of mortality, combined end point at 30 days, one year

Genetics Stratification May Improve Noncompaction Cardiomyopathy Care

February 14, 2018

The researchers found that MYH7, MYBPC3, and TTN mutations were the most common mutations (71%) found in genetic NCCM.

ICD placement in CKD patients increases hospitalizations without survival benefit

February 13, 2018

Adults with chronic kidney disease (CKD) and heart failure with reduced LVEF who received implantable cardioverter defibrillators (ICDs) did not differ from matched non-ICD patients with relation to all-cause mortality.

AHA: Managing Breast CA Patients CVD Risk Requires Comprehensive Care

February 01, 2018

Current treatment for breast cancer can have a negative effect on cardiovascular health such as left ventricular dysfunction and accelerated CVD;

Catheter Ablation Mortality Outcomes Examined in A-Fib With Heart Failure

February 01, 2018

In the ablation group, significantly fewer patients died from any cause, were hospitalized for worsening heart failure, or died from cardiovascular causes.

FDA to Limit Amount of Doses in OTC Antidiarrheal Packages

By January 30, 2018

The FDA will be working with manufacturers to use blister packs or other single-dose packaging in efforts to limit the number of doses in a package.

Viral respiratory infections associated with increased risk of acute myocardial infarction

January 30, 2018

In a self-controlled case series, patients were observed to have increased incidence of hospital admissions for acute myocardial infarction (MI) within seven-days of respiratory virus detection.

FDA Approves Generic Bumex Tablets

By January 30, 2018

The company stated that they are prepared to begin shipping product to wholesalers in early February 2018.