People with major illnesses, including liver or kidney disease, rheumatoid arthritis, multiple sclerosis, heart failure, hemorrhagic stroke, or arterial thrombosis, have an increased risk of venous thrombosis that dramatically increases during periods of immobilization or in the presence of thrombophilia.
There is evidence of impaired behavioral and neural processing of sequential information in fetal alcohol spectrum disorders.
Adults with cerebral palsy may be able to reduce declines in muscle strength, improve function, and reduce cardiovascular and metabolic disease by avoiding sedentary behavior and engaging in physical activity.
Children who watch a video clip of their choice during induction of inhaled anesthesia are less anxious than children who receive traditional distraction methods.
For older people with white matter changes living independently, physical activity lowers the risk of cognitive impairment.
Combination therapy is an acceptable first-line approach for manic episodes in terms of efficacy and prevention of relapse, with an acceptable safety profile.
A new study published in the journal Human Reproduction is challenging prior practice that it is safe for pregnant women who suffer from depression to take antidepressants.
Genzyme, a Sanofi company, announced updated results from the Lemtrada (alemtuzumab) Phase 3 CARE-MS I and CARE-MS II pivotal studies in patients with relapsing-remitting multiple sclerosis (MS).
Sunovion announced that the FDA has accepted two supplemental New Drug Applications (sNDAs) for the use of Latuda (lurasidone HCl) as 1) monotherapy and 2) adjunctive therapy to lithium or valproate, both to treat adult patients with depressive episodes associated with bipolar I disorder (bipolar depression).
A genetic marker previously identified as associated with smoking may also be associated with attention-deficit/hyperactivity disorder (ADHD).
For young children with autism spectrum disorder (ASD), early behavioral intervention is associated with normalized brain activity patterns, which correlate with improvements in social behavior
The development of children with autism spectrum disorder (ASD) is similar to children without the disorder at 6 months of age, suggesting that ASD has a pre-clinical phase of varying duration when detection may be difficult.
Most nonagenarians carry the ApoE ε3 genotype and few carry the ApoE ε4 genotype, with no association noted between the ApoE ε4 allele and quality of life (QOL).
Proposed criteria for hypersexual disorder (HD) show high reliability and validity.
Use of hormone therapy (HT) within five years of menopause is associated with a reduction in the risk of Alzheimer's disease (AD).
Poor physical performance is associated with increased odds of dementia among the oldest old.
In older adults, physical activity is associated with less brain atrophy and white matter lesion (WML) load.
Adolescents exposed to recent victimization have an increased risk for suicide ideation, with a higher risk for those exposed to polyvictimization.
A single bout of moderate intensity aerobic exercise may improve neurocognitive function and inhibitory control for children with attention-deficit/hyperactivity disorder (ADHD).
A considerable number of varsity high school football players continue not to seek medical attention for concussion-like symptoms due to concerns of being excluded from play, and most are not concerned about the long-term effects of concussions.
Extradural motor cortex stimulation seems safe and moderately improves symptoms in Parkinson's patients one year after implantation.
Eisai announced that the FDA has approved Fycompa (perampanel tablets) as an adjunctive treatment for partial-onset seizures with or without secondarily generalized seizures in patients with epilepsy >12 years old.
Supernus Pharmaceuticals received approval from the FDA for Oxtellar XR (oxcarbazepine extended-release tablets) for use as adjunctive therapy in the treatment of partial seizures in adults and in children 6-17 years of age.
A simple stress reduction technique, the 10-minute "Tension Tamer," can significantly reduce stress and improve sleep quality and fatigue.
Unlike typically developing children, children with autism do not use language areas of the brain to identify socially inappropriate behavior.
Exposure to selective serotonin reuptake inhibitors (SSRIs) is associated with an increased risk of intracerebral and intracranial hemorrhage.
Preterm neonates born to low-income parents have a disproportionately high risk of developing posthemorrhagic hydrocephalus (PHH) that requires multiple surgeries and extensive follow-up.
For college athletes, diagnosed concussions are associated with a specific contact event about two-thirds of the time, and diagnosis is often based on self-reported symptoms after a variable delay.
Elevated cerebral β-amyloid (Aβ) load is associated with greater decline in episodic and working memory for healthy and cognitively normal older adults over an 18-month period, with a larger effect than that seen for the APOE ε4 allele.
The antiepileptic drug zonisamide, at a dosage of 400mg per day, is associated with enhanced weight loss for obese patients when combined with diet and lifestyle counseling, but the incidence of adverse events is high.
For children with attention-deficit/hyperactivity disorder (ADHD) without conduct disorders, the psychopathological consequences extend into adulthood, although most of these consequences begin in adolescence.
For children aged 7-11 years, a moderate increase in sleep correlates with improvement in emotional regulation and alertness, while the opposite effects are observed with sleep restriction.
Biogen Idec announced new data from Phase 3 studies evaluating oral BG-12 (dimethyl fumarate), which provide further evidence supporting its clinical and radiological effects in people with relapsing-remitting multiple sclerosis (RRMS).
For older adults, decreases in pulmonary function lead to subsequent declines in cognitive function.
Negative news appears to have an impact on stress reactivity and memory in women, more so than in men.
Cannabis extract (CE) is effective at treating muscle stiffness in patients with multiple sclerosis (MS).
Adolescent boys and boys and girls with health-related vulnerabilities who move from high-poverty public housing arrangements to low-poverty private apartments do not experience mental health benefits, although some girls without health vulnerabilities do benefit.
Daily low-dose aspirin treatment may reduce global cognitive decline in older women at high risk for cardiovascular disease.
Edgemont Pharmaceuticals announced that Forfivo XL (bupropion HCl extended-release tablets) is now available nationwide for the treatment of major depressive disorder (MDD).
Maternal mood and exposure to serotonin reuptake inhibitors (SRIs) in pregnancy affect development of the infant speech perception system.
The risk of developing attention-deficit/hyperactivity disorder (ADHD) is higher with low-level prenatal mercury exposure, but lower with maternal fish consumption during pregnancy.
Nearly half of children with autism spectrum disorders (ASDs) wander away, with considerable numbers of them facing physical danger.
Humanitarian relief workers have increased levels of anxiety and depression after being deployed.
Preschool children with fetal alcohol spectrum disorder (FASD) display delays in auditory processing, which may serve as a useful neural marker of information processing difficulties.
The FDA has reviewed new data that indicate Budeprion XL 300mg (bupropion HCl extended-release tablets; Impax Laboratories), marketed by Teva, is not therapeutically equivalent to GlaxoSmithKline's Wellbutrin XL 300mg.
Fertility treatment is associated with a higher risk of multiple sclerosis (MS) exacerbations, which is linked to the increase in reproductive hormones affecting immune function.
In patients with multiple sclerosis (MS) without a history of optic neuritis, retinal measures reflect global central nervous system pathology.
Insomnia-related workplace accidents and errors are more costly and more frequent than accidents and errors caused by other chronic conditions.
As many as half of the children and adolescents who are in juvenile detention have psychiatric disorders five years after release.
Takeda and Lundbeck jointly announced the submission of a New Drug Application (NDA) to the FDA for the investigational agent vortioxetine (Lu AA21004) for the treatment of major depressive disorder (MDD) in adult patients.
Patients taking β-blockers for hypertension, which can disturb sleep, have improved sleep quality with melatonin treatment.
NextWave Pharmaceuticals announced that the FDA has approved Quillivant XR (methylphenidate hydrochloride extended-release oral suspension) for the treatment of attention deficit hyperactivity disorder (ADHD). Quillivant XR is the first once-daily extended-release liquid methylphenidate available for patients.
Over 60 percent of women have male DNA in their brains, possibly from a prior pregnancy with a male fetus, which is associated with a lower prevalence of Alzheimer's disease.
New use of benzodiazepines correlates with an increase in the risk of dementia.
After 15 years of follow-up, patients with relapsing-remitting multiple sclerosis (RRMS) who display disease activity despite treatment with interferon (IFN)β-1a tend to have unfavorable long-term outcomes.
Functional somatic symptoms (FSS) in childhood may be predicted by feeding, sleeping, or tactile reactivity problems in the first 10 months of life,
A complementary medicine intervention of healing touch with guided imagery (HT+GI) reduces post-traumatic stress disorder (PTSD) and related symptoms in returning combat-exposed active duty military personnel.
A considerable proportion of severe intellectual disability results from de-novo genetic variants, suggesting that only a small proportion of cases are likely to be inherited in an autosomal recessive fashion.
Patients with multiple sclerosis (MS) can be differentiated according to their transcription profile
Forest Laboratories and Pierre Fabre announced that Forest has submitted a New Drug Application (NDA) to the FDA for levomilnacipran for the treatment of major depressive disorder (MDD) in adults.
Increased stress is tied to weight gain in teenage girls, particularly black girls.
For children with autism spectrum disorder (ASD), a possibly interrelated phenomenon of co-existing anxiety, sensory over-responsivity, and gastrointestinal (GI) problems is common
Patients with sporadic Jakob-Creutzfeldt disease (sCJD) are often misdiagnosed, with only 18 percent correctly diagnosed at their first assessment.
Leaders have lower levels of cortisol and lower reports of anxiety, with a dose-response association seen for levels of leadership, which seems to be mediated by a sense of control.
Deaths due to suicide, falls, and unintentional poisoning increased over the last decade, while motor vehicle accident deaths declined by 25%
There is a lack of evidence supporting the use of medications in adolescents and young adults with autism spectrum disorders (ASDs).
A simple, structured risk assessment tool, the Historical, Clinical, Risk Management-20 clinical subscale (HCR-20-C), could help psychiatric residents more accurately evaluate the risk for violence among patients.
Poor sleep duration is independently associated with a doubling of the risk of resistant hypertension (RH), but the association may be mediated by depressive symptoms.
The anxiety-lowering effect of exercise seems to persist even after exposure to emotional stimuli.
Emotional neglect as a child may be tied to a higher risk of stroke as an adult
Biogen Idec announced detailed results from its two pivotal clinical trials evaluating oral BG-12 (dimethyl fumarate) for the treatment of multiple sclerosis (MS).
For individuals with suspected sporadic Creutzfeldt-Jakob disease (sCJD), the cerebrospinal fluid (CSF) 14-3-3 protein assay is a useful diagnostic test.
The FDA notified healthcare professionals about a possible increased risk of heart failure with Mirapex (pramipexole tablets; Boehringer Ingelheim).
People who self-harm have over three-fold higher rates of premature death, from both natural and external causes.
Patients with invasive malignancies who take L-carnitine supplements do not experience a reduction in fatigue, pain, or depression.
Health ambiguity, or uncertainty about the outcome of illness, is significantly associated with depression in survivors of first stroke, and this association is stronger for men than women.
Out-of-pocket health care expenditures can put a significant financial burden on elderly Medicare beneficiaries in their last five years of life.
There is an increased risk of motor vehicle accidents (MVAs) for patients taking antidepressants, benzodiazepines, or Z-drugs.
There has been a substantial increase in antipsychotic use among Medicaid-enrolled children in recent years, with the increase partially driven by youth with attention-deficit/hyperactivity disorder (ADHD) and those with multiple diagnoses.
Noise-impact indicators, such as the percentage of the population who are highly annoyed and who have high levels of sleep disturbance, can be valuable metrics in comparing noise equity among urban communities.
Mothers who receive a prenatal diagnosis of congenital heart disease (CHD) commonly report posttraumatic stress, depression, and anxiety.
Genzyme announced that the FDA has approved Aubagio (teriflunomide tablets), a new once-daily, oral treatment indicated for patients with relapsing forms of multiple sclerosis (MS).
In autopsy findings, patients treated with angiotensin receptor blockers (ARBs) show less Alzheimer's disease (AD)-related pathology.
Shire announced that the FDA has accepted the filing for review of a supplemental New Drug Application (sNDA) for Vyvanse (lisdexamfetamine dimesylate) Capsules (CII), seeking approval as a maintenance treatment in children and adolescents aged 6-17 years with Attention-Deficit/Hyperactivity Disorder (ADHD).
Patients with Parkinson's disease may benefit from acupuncture treatment on acupoint GB34, with improved neural response noted after acupuncture stimulation.
Nearly 20% of infants and preschoolers with cancer suffer from posttraumatic stress disorder (PTSD)
The previously reported association between attention-deficit/hyperactivity disorder (ADHD) and gestational diabetes mellitus (GDM) and low socioeconomic position (SEP) has been confirmed in a large German cohort.
Infant sleep training techniques employed to reduce the short- to medium-term burden of infant sleep problems do not have lasting effects.
Maternal depression at nine months postpartum may negatively affect physical growth in early childhood.
Verbalizing fear may play a role in regulating the emotional aspects of fear.
Merck announced new data for suvorexant, an investigational medicine in development for the treatment of insomnia.
Preschoolers classified as extremely socially and academically disengaged have the lowest academic skills, compared with their peers.
Neurological disorders such as Parkinson's disease and attention-deficit/hyperactivity disorder (ADHD) can be detected with high accuracy by tracking eye movements while watching television.
Nearly half of adolescents with autism spectrum disorders (ASDs) are victims of bullying.
For elderly adults with memory complaints, use of standardized ginkgo biloba extract is no better than placebo for reducing the incidence of Alzheimer's disease.
Sunovion announced that it has submitted two supplemental New Drug Applications (sNDAs) to the FDA seeking approval for the use of Latuda (lurasidone HCl) as 1) monotherapy and 2) adjunctive therapy to lithium or valproate, both to treat adult patients with depressive episodes associated with bipolar I disorder (bipolar depression).
Neurodegenerative mortality is about three times higher among retired National Football League players, with Alzheimer's disease and amyotrophic lateral sclerosis mortality even higher, compared to the general U.S. population.
Patients with Parkinson's disease (PD) have a significantly increased risk of prostate cancer and melanoma, which extends to their third-degree relatives, and there is evidence of a reciprocal risk.
Combat stress has adverse effects on the mesofrontal circuit of the brain that are partially reversible.
Women with low expression of a gene involved in breaking down neurotransmitters report greater happiness.