CELLCEPT CAPSULES

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Generic Name for CELLCEPT CAPSULES Mycophenolate mofetil 250mg. Legal Classification: Rx Pharmacological Class for CELLCEPT CAPSULES Immunosuppressant. Manufacturer of CELLCEPT CAPSULES Roche Laboratories

Indications for CELLCEPT CAPSULES

Organ rejection prophylaxis in allogeneic renal, cardiac or hepatic transplant patients, in combination with cyclosporine and corticosteroids.

Adult dose for CELLCEPT CAPSULES

Give as soon as possible after transplantation on empty stomach. Renal: 1g twice daily (2g/day). Cardiac or hepatic: 1.5g twice daily (3g/day). Severe renal impairment: see literature.

Children's dosing for CELLCEPT CAPSULES

<3months: not recommended. Give as soon as possible after transplantation on empty stomach. Renal: 3months–18years: Oral susp: 600mg/m² twice daily (max 2g/10mL per day); also, may give via NG tube. BSA: 1.25m² to 1.5m²: 750mg twice daily (1.5g/day), may give in caps; if >1.5m²: 1g twice daily (2g/day), may give in caps or tabs.

Also:

Contraindications for CELLCEPT CAPSULES

Hypersensitivity to other forms of mycophenolate. IV: polysorbate 80 allergy.

Warnings/Precautions for CELLCEPT CAPSULES

Increased risk of infections, lymphomas and other malignancies (eg, skin). Avoid sun, UV light. Rule out pregnancy before starting therapy. Monitor CBCs weekly for 1 month, twice monthly for 2 months, then monthly during first year. If ANC<1300/µL, discontinue or reduce dose. Active GI disease or renal impairment (monitor). Hypoxanthine-guanine phosphoribosyl transferase deficiency; avoid. Pregnancy (Cat.D); avoid; counsel patients to use 2 forms of contraception 4 weeks before and during therapy, and for 6 weeks after discontinuation. Nursing mothers: not recommended.

Interactions for CELLCEPT CAPSULES

Concomitant azathioprine, live vaccines, rifampin, or the combination of norfloxacin and metronidazole: not recommended. Antagonized by antacids (separate dosing), cholestyramine, drugs that bind bile acid or alter GI flora. Antagonizes oral contraceptives; use additional birth control methods. May potentiate or be potentiated by acyclovir, ganciclovir, probenecid. Antagonized by sevelamer and other calcium-free phosphate binders; may give 2 hours after mycophenolate mofetil.

Adverse Reactions for CELLCEPT CAPSULES

Blood dyscrasias, constipation, GI upset, peripheral edema, hypertension, infections (eg, UTI, cytomegalovirus, sepsis, herpes), progressive multifocal leukoencephalopathy, pure red cell aplasia (w. concomitant immunosuppressants), malignancies (eg, lymphomas, skin), insomnia; rare: GI bleeding, ulceration, perforation. IV: phlebitis, thrombosis.

How is CELLCEPT CAPSULES supplied?

Caps, Tabs—100, 500
Susp—225mL (w. bottle adapter and 2 oral dispensers)
Vials (20mL)—4

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