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CARDIZEM CD
Angina
Hypertension
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Drug Name:

CARDIZEM CD Rx

Generic Name and Formulations:
Diltiazem HCl 120mg, 180mg, 240mg, 300mg, 360mg; ext-rel caps.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for CARDIZEM CD:

Vasospastic and chronic stable angina.

Adult:

Initially 120–180mg once daily. Titrate over 7–14 days; usual max 480mg once daily.

Children:

Not recommended.

See Also:

CARDIZEM

CARDIZEM LA

Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

Warnings/Precautions:

Heart failure. Impaired renal or hepatic function (monitor). Obstructive hypertrophic cardiomyopathy. Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, cyclosporine, carbamazepine, lovastatin, simvastatin (consider dose adjustment; monitor). Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.

Adverse Reactions:

Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, flushing, nausea, rash (may be serious); rare: CHF, hypotension, liver abnormalities.

How Supplied:

LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90; Tabs 30mg, 60mg—100, 500; 90mg, 120mg—100

Indications for CARDIZEM CD:

Hypertension.

Adult:

Initially 180–240mg once daily; adjust at 2-week intervals. Usual range: 240–360mg once daily; usual max 480mg once daily.

Children:

Not recommended.

See Also:

CARDIZEM LA

Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

Warnings/Precautions:

Heart failure. Impaired renal or hepatic function (monitor). Obstructive hypertrophic cardiomyopathy. Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, cyclosporine, carbamazepine, lovastatin, simvastatin (consider dose adjustment; monitor). Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.

Adverse Reactions:

Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, flushing, nausea, rash (may be serious); rare: CHF, hypotension, liver abnormalities.

How Supplied:

LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90

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