Cardiovascular Diseases

PPIs May Benefit Older Patients on Antiplatelet Therapy

June 15, 2017

Research suggests proton-pump inhibitors should be co-prescribed in patients age 75 years

Cardio-, Cerebrovascular Safety of Ranibizumab in DME Evaluated

April 10, 2017

The researchers assessed the cardiovascular and cerebrovascular safety of ranibizumab 0.3mg and 0.5mg vs. sham with and without laser in diabetic macular edema.

BMI-Related Heart Failure Risk Tied to Cardiorespiratory Fitness

April 07, 2017

The researchers observed 1,038 heart failure hospitalization events after 127,110 person-years of follow-up.

Evinacumab Gets Breakthrough Status for Severe Form of Hypercholesterolemia

By April 06, 2017

Regeneron previously reported positive interim Phase 2 results which showed that evinacumab added to current lipid-lowering therapy reduced low-density lipoprotein cholesterol (LDL-C) levels by an additional 55%.

No CVD Benefits with Multivitamin Use for Patients with Poor Diets

By April 06, 2017

The data revealed "no consistent evidence of effect modification by various foods, nutrients, dietary patterns, or baseline supplement use" with multivitamin use on cardiovascular disease outcomes.

ASA Hyporesponsiveness After CABG May Be Overcome by Multiple Dosing

March 22, 2017

Multiple dosing more effective than ASA 81 or 325 mg once-daily for suppressing serum TXB2 formation

Evolocumab Reduces LDL-C Apheresis Need in Phase 3 Study

By March 13, 2017

Treatment with Repatha reached its primary endpoint of reducing the need for continued apheresis at the end of the randomization period.

FDA Warns of Unapproved Treatment for Autonomic Dysfunction

By March 09, 2017

Serious side effects, including one fatality, have been reported.

NOAC Prescribing Up in Afib But Many Still Undertreated

February 14, 2017

Non-vitamin K antagonist oral anticoagulants prescribed more often than vitamin K antagonists

Are Migraine Sufferers at Increased Risk for Stroke After Surgery?

January 12, 2017

Migraine sufferers may face a slightly higher risk of stroke after an operation, according to research published online January 10 in The BMJ.

Gut Metabolite Produced During Digestion May Help Predict ACS

January 12, 2017

A metabolite produced in the digestion of red meat, eggs, and dairy products - trimethylamine N-oxide (TMAO) - is linked to an increased risk of a fatal myocardial infarction or stroke.

New Oral Anticoagulant NDA Granted Priority Review

By December 28, 2016

Betrixaban has the potential to be the first anticoagulant approved for in-hospital and extended-duration VTE in high-risk acute medically ill patients.

Study Highlights Cardiovascular Concerns for HIV Patients

December 21, 2016

The risk of heart attack and stroke among patients with HIV was predicted to be nearly double that of the general population

Outcomes of Tranexamic Acid Use Assessed in Coronary Surgery Patients

October 26, 2016

Tranexamic acid is associated with a lower risk of bleeding than placebo for patients undergoing coronary artery surgery without increased risk of death or thrombotic complications, according to a study published online in the New England Journal of Medicine

FDA: Statement on the Impact of Recalled Monitoring Device on Rivaroxaban Study

By October 11, 2016

The ROCKET-AF study provided the primary data to support the 2011 approval of Xarelto.

Warnings and Precautions Updated for Brilinta

By September 26, 2016

Brilinta is a P2Y12 platelet inhibitor.

Effect of BP Meds on Dementia Risk Explored

By July 14, 2016

Non-dihydropyridine calcium channel blockers and loop diuretics were associated with a lower risk of dementia independent of blood pressure variability (percent coefficient of variation [CV]) in the preceding 4 years, researchers found in a study published in Neurology.

Impaired Cardiac Function Correlates With Reduced CFR in T2D

July 11, 2016

Impaired cardiac autonomic function is associated with coronary flow reserve (CFR) in patients with type 2 diabetes, according to a study published in the June issue of Diabetes.

Cholesterol, Cancer, and the Drug Class that May Be Key

By July 08, 2016

Research presented at Frontiers in CardioVascular Biology (FCVB) 2016 shows that a diagnosis of high cholesterol was associated with lower mortality and improved survival in four common cancers: lung, breast, prostate, and bowel.

FDA Reviews Aggrastat sNDA, Needs More Information for Expanded Indication

By July 08, 2016

The FDA has issued a Complete Response Letter for the supplemental New Drug Application (sNDA) of Aggrastat (tirofiban; Medicure) for the expanded indication in patients with ST segment elevation myocardial infarction (STEMI).

VKA Use and Bleeding, Thrombosis Risk Evaluated in Patients Over 70

By July 06, 2016

After age 80, the bleeding risk with a vitamin K antagonist (VKA) only mildly increases whereas the thrombosis risk in this patient population sharply increases, a study in JAMA Internal Medicine reports.

Familial Hypercholesterolemia Patients Have Higher CVD Risks

July 06, 2016

Patients with heterozygous familial hypercholesterolemia (FH) have a significantly increased risk for coronary heart disease (CHD) and atherosclerotic cardiovascular disease (ASCVD), according to research published online in Circulation.

Blood Clots May be Directly Targeted With Magnetically Controlled Enzyme

By June 23, 2016

A new magnetically controlled drug may be able to dissolve a blood clot without negatively affecting the entire network of blood vessels.

Study Finds Significant HF Mortality Reductions with ARNI Therapy

By June 23, 2016

The sensitivity analysis showed a lower limit of 18,230 preventative deaths per year associated with ARNI.

Tablet Splitting Can Significantly Vary Doses, FDA Study Finds

By June 23, 2016

An FDA report found that certain split tablets did not meet USPs Uniformity of Dosage Units accepted criteria.

Real-World Study Compares Treatment Persistence, Discontinuation of Oral Anticoagulants in Afib Patients

By June 22, 2016

Rivaroxaban, a non-vitamin K antagonist (VKA) oral anticoagulant, was found to have better persistence and lower discontinuation rates than, the VKA warfarin and the non-VKA, dabigatran.

LDL Targets May Need Reevaluation for Some CVD Patients, Study Finds

June 21, 2016

Very low target low-density lipoprotein (LDL) cholesterol levels may not benefit all patients with preexisting heart disease, according to a study published online June 20 in JAMA Internal Medicine.

Do Statins Improve Outcomes in COPD Patients?

By June 21, 2016

Statin use was not associated with a lower risk of all-cause mortality or time until first hospitalization for an acute exacerbation of chronic obstructive pulmonary disease (COPD), a study published in BMJ Open Respiratory Research has found.

Can Statin Use Lower the Risk of Post-Stroke Infections?

By June 17, 2016

For patients with ischemic stroke without endotracheal intubation, use of statins were associated with a reduced risk of nosocomial infections, study authors from Washington State University reported.

Recombinant tPA May Be Safe For Wake-Up Stroke Patients

June 17, 2016

For patients with wake-up stroke (WUS), treatment with recombinant tissue plasminogen activator (rtPA) seems safe, according to a study published online in the Annals of Neurology.