Cardiovascular Disease

NSAID Use May Increase Atrial Fibrillation Risk for Some

By March 21, 2018

NSAID use was associated with an 18% increased risk of Afib in this population.

Can Omega-6 Fatty Acids Protect Against Premature Death, CV Disease?

By March 19, 2018

After classifying patients into 5 groups based on their blood linoleic level, the researchers found a 43% reduced risk of premature death among those with the highest level when compared with the group with the lowest level (adjusted hazard ratio [HR] 0.57, 95% CI: 0.46, 0.71; P<0.00).

Hemodynamic markers of pulmonary hypertension in HFpEF are associated with mortality

March 19, 2018

Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is common in patients undergoing a right heart catheterization.

Ticagrelor and clopidogrel have similar major bleeding rates following thrombolytic therapy

March 19, 2018

Use of ticagrelor resulted in similar rates of major bleeding compared to clopidogrel in patients with ST elevation myocardial infarction treated with thrombolysis.

Low Sperm Count Associated With Worse Cardiometabolic Health

March 19, 2018

Low sperm counts linked to hypogonadism, higher BMI, hypertension, dyslipidemia, metabolic syndrome

Generic Clopidogrel Compared to Plavix for Seniors With Acute Coronary Syndrome

March 19, 2018

The researchers found that the primary outcome was experienced by 17.6% of patients prescribed Plavix and 17.9% prescribed clopidogrel at 1 year (hazard ratio, 1.02; 95% confidence interval, 0.96 to 1.08; P=0.005 for noninferiority).

Pulmonary Hypertension in HFpEF: Outcomes Examined in Patients With Heart Catheterization

March 16, 2018

Cardiac hospitalizations occurred in 28.1 and 47.4% at 1 and 5 years, respectively. Using clinically defined cut-offs for transpulmonary gradient (>12mm Hg), pulmonary vascular resistance (3 Woods units), and diastolic pulmonary gradient (≥7mm Hg), the frequency of precapillary PH was 12.6, 8.8, and 3.5%, respectively.

Environmental Lead Exposure May Increase CVD Mortality Risk

March 16, 2018

Environmental lead exposure tied to all-cause, cardiovascular disease, ischemic heart disease mortality

Comparative Safety of NSAIDs Among Clopidogrel Users Investigated

By March 15, 2018

Using Medicaid claims from 5 states (1999-2010) and Medicare claims for dual-enrollees, study authors analyzed the first concomitant use of clopidogrel and 1 of 10 selected NSAIDs (ibuprofen, celecoxib, naproxen, rofecoxib, meloxicam, diclofenac, indomethacin, valdecoxib, nabumetone, etodolac) after a 1-year baseline period.

Genetic Heart Diseases May Cause Less Cases of SIDS Than Previously Thought

March 15, 2018

The researchers found that 53 SIDS cases (12.6%) had at least 1 "potentially informative" GHD-associated variant. For mixed-European ancestry cases, the yield was 14.9% (21 of 141), and for European ancestry SIDS cases it was 11.5% (32 of 278).

Study Examines Hazard of Mortality for A-Fib Patients Receiving Digoxin

March 15, 2018

However, compared with patients not on digoxin, patients with a serum digoxin concentration ≥1.2 ng/mL had a 56% increased hazard of mortality (adjusted HR, 1.56; 95% confidence interval, 1.2 to 2.04). For each 0.5-ng/mL increase (P=0.001), there was a 19% higher adjusted hazard for death, and these results were similar in patients with and without heart failure.

Icosapent Ethyl Significantly Lowers Triglycerides Without Raising LDL-C

By March 14, 2018

The ANCHOR study was not designed to determine effects on hsCRP or CV events.

Suboptimal LDL-C in FH Patient Despite Use of Three Cholesterol-Lowering Meds

By March 13, 2018

Some FH patients may have suboptimal LCL-C despite treatment with PCSK9 inhibitors, statins and ezetimibe.

Cocaine/Marijuana May Up Mortality in Younger MI Patients

March 13, 2018

Cocaine and/or marijuana use present in 10.7% of myocardial infarction patients age ≤50 years

Centrifugal-Flow Pump Compared With Axial-Flow Pump in Advanced HF

March 13, 2018

Magnetically levitated centrifugal-flow pump beats mechanical bearing axial-flow pump at two years

Dabigatran Cuts Risk of Major CV Complications in Patients With MINS

By March 13, 2018

The primary efficacy outcome was the combined rate of death from a cardiovascular cause, heart attack, stroke due to inadequate blood supply, blood clots or amputation due to cardiovascular disease.

Novel Inhaled Tx Found to Be Ineffective for Patients With Heart Failure

By March 13, 2018

The trial enrolled 105 patients who had HFpEF causing shortness of breath and fatigue with ordinary or mild physical activity.

Medical Intervention in Barbershops Effective for BP Reduction

By March 12, 2018

The study recruited 319 men at 52 Los Angeles County barbershops.

Alirocumab Tied to Reduced Risk of CV Events, Death in High-Risk Patients

By March 12, 2018

The ODYSSEY Outcomes trial (N=18,924) evaluated the effect of alirocumab on the occurrence of MACE in patients who had an ACS between 1-12 months prior to trial enrollment, and who were already taking maximally-tolerated statins (atorvastatin or rosuvastatin).

Canagliflozin Cuts Hospitalization Risk for HF in Type 2 Diabetes Patients

By March 12, 2018

The results showed canagliflozin was associated with a significant reduction in risk of CV death or HHF by 22%.

Use of Carvedilol for Anthracycline Cardiotoxicity Prevention Investigated

March 12, 2018

Carvedilol does not prevent reduction in LVEF in breast cancer but is linked to lower troponin I levels

Febuxostat Linked to Increased Death Risk in Gout Patients With Heart Disease

March 12, 2018

Participants were followed for a median of 32 months.

Ticagrelor vs Clopidogrel: TIMI Major Bleed Rates Compared Post-Fibrinolysis

By March 12, 2018

After 30 days of treatment the analysis found that major bleeding - the most common complication with blood thinners - occurred at the same level (0.7%) for patients in both treatment groups

Researchers Develop Smartphone Device to Measure Blood Pressure

By March 09, 2018

When the app is turned on, users press their fingertip against the sensor while the app informs them if the pressure being applied is requisite, and in turn the app provides the blood pressure reading.

Link Between FGF23 Concentrations and Heart Disease Examined

March 09, 2018

After adjustment for established CHD risk factors and kidney function, higher FGF23 concentrations were correlated with increased risk of CHD (hazard ratio comparing fourth with first quartile, 2.15).

Pharmacists Playing Key Role in Cardiac Management, Report Finds

March 09, 2018

"It's important for a patient to understand their meds, as well as to understand why lifestyle issues, such as diet and exercise are important," Mary Curtis, PharmD, from Bremo Pharmacy, said in a statement.

FDA Approves Smallest Ever Mechanical Heart Valve

By March 07, 2018

Findings from a single-arm study (N=20) of pediatric patients with serious heart failure (aged 1.5 weeks to 27 months) at the time of mitral valve implant were reviewed by the Agency. Study data showed a 69.3% probability of survival post-implant and a 66.8% probability of not experiencing a valve-related adverse event.

Combination Hypertension Treatment Discontinued

By March 07, 2018

The Food and Drug Administration (FDA) has posted a discontinuation notice for Twynsta (telmisartan, amlodipine; Boehringer Ingelheim) 80mg/10mg tablets.

Hypertension Evaluation

March 05, 2018

Blood pressure classification, diagnostic workup of hypertension, assess for major cardiovascular disease risk factors and identifiable causes, and blood pressure measurement techniques.

Ready-to-Use Esmolol HCl in Water for Injection Available

By March 01, 2018

Esmolol will be available in two presentations—ready-to-use Esmolol HCl In Water for Injection 2500mg/250mL and ready-to-use Esmolol HCl DOUBLE STRENGTH In Water for Injection 2000mg/100mL.