Cardiovascular Disease

Cancer, CV Risks Examined for Vaginal Estrogen Tx in Postmenopausal Women

By August 16, 2017

The data showed women with an intact uterus did not have a significantly different risk of stroke, invasive breast cancer, colorectal cancer, endometrial cancer, and pulmonary embolism/deep vein thrombosis (PE/DVT) between those who used vaginal estrogen and those who did not.

Prenatal Falling Insulin Requirement Linked to Complications

August 16, 2017

The researchers found that FIR ≥15% correlated with an increased risk of the composite primary outcome (odds ratio, 4.38) and preeclampsia (odds ratio, 6.76), and was more common among women with type 1 diabetes (36.6 versus 14.5%)

Light, Moderate Alcohol Intake May Protect Against All-Cause, CVD Death

August 15, 2017

Risk of mortality for all causes, cancer up for adults with heavy alcohol consumption, binge drinking.

Reduced Risk of Intraocular Bleeding with Novel Oral Anticoagulants

By August 14, 2017

The main outcomes and measures were intraocular bleeding events and associated risk ratio for NOACs, compared with warfarin.

Diuretic Linked to Acute Pancreatitis in Patient with Coronary Artery Disease

By August 14, 2017

Furosemide-induced acute pancreatitis can occur several hours to up to 7 weeks after starting treatment; dose may also play a role. This patient, the authors note, fell into the category of "long-term latency" and "low-dosage (40mg)"

Recall: Antidepressant Tablets Found in Bottle Labeled for Cholesterol Med

By August 10, 2017

While side effects of bupropion are typically minor, some patients may be at greater risk for adverse effects.

Marijuana Use May Increase Risk of Death from Hypertension

August 10, 2017

Over 19,569 person-years of follow-up, the adjusted hazard ratios for death from hypertension among marijuana users was 3.42 (95% confidence interval, 1.20 to 9.79).

Nikita Approved to Treat Primary Hyperlipidemia, Mixed Dyslipidemia

By August 09, 2017

The efficacy of pitavastatin has been evaluated in multiple clinical studies.

Non-Invasive ECG Device Gets FDA Clearance

By August 09, 2017

Clinical data from the Turbulence study (n=1,807) showed CADence had comparable performance to a SPECT nuclear stress test in excluding obstructive CAD in patients with chest pain and risk factors.

CVD Risk Significantly Heightened in Years Follow Severe Infection

August 09, 2017

While the first year after infection has the highest risk (adjusted hazard ratio [aHR], 6.33), an increased risk persists for the second (aHR, 2.47) and third year (aHR, 2.12) after infection.

Heart Failure with Preserved Ejection Fraction: Treatments Compared

By August 08, 2017

A total of 25 randomized controlled trials involving 18,101 patients were included for the analysis.

Angioedema Risk Assessed for Aliskiren vs. Other Antihypertensives

By August 07, 2017

The case-control analysis found no significant difference in the angioedema risk for aliskiren monotherapy and fixed-dose combination compared to BBs with adjusted odds ratio of 0.99 (95% CI, 0.45-2.20) and 1.06 (0.40-2.76), respectively.

Vitamin B Effects on Fracture Risk Examined in Women at High CVD Risk

August 07, 2017

The researchers found that B vitamin supplementation had no significant effect on non-spine fracture risk (relative hazard, 1.08; 95% confidence interval, 0.88 to 1.34).

FDA Approves CaroSpir, an Oral Suspension Formulation of Spironolactone

By August 07, 2017

CaroSpir, an aldosterone antagonist, works primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tube.

Statin Rx Given to Less than Half of Stroke Patients at Discharge

August 03, 2017

The researchers restricted analyses to 323 of the 666 patients with incident stroke who were not statin users at the time of admission and had no history of atrial fibrillation.

Scientists Correct Disease-Causing Gene Mutation in Human Embryos

By August 02, 2017

Using the gene-editing tool CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) the researchers worked with healthy donated human oocytes and sperm carrying the genetic mutation that causes cardiomyopathy.

Publication of Drug Interaction Unlikely to Impact Prescribing Patterns

By August 02, 2017

The findings point to "minimal to no measurable effect" in lowering the concomitant use.

Canagliflozin CV Biomarker Effects Examined in Diabetes Patients

August 02, 2017

The researchers observed increases in serum NT-proBNP and serum hsTnI levels in placebo recipients, but these levels remained largely unchanged in canagliflozin recipients.

Obeticholic Acid + Statin Shows Rapid Reversal of LDL Rise in NASH Patients

By August 02, 2017

The mean LDL change from baseline to Week 16 were as follows: placebo: -48 mg/dL, OCA 5mg: -40mg/dL, OCA 10mg: -40mg/dL, and OCA 25mg: -45mg/dL.

Cardiovascular Disease Correlated to Daily Sodium Intake Threshold

August 01, 2017

ESI >3.7 g/day correlated with strain parameters and e' velocity, while ESI ≤3.7 g/day was not, after adjustment for speckle-tracking analyst, image quality, study site, age, sex, smoking status, alcohol use, daily blocks walked, diuretic use, estimated glomerular filtration rate, left ventricular mass, ejection fraction, and wall motion score index.

Orthostatic Hypotension Guidelines Called into Question

By July 31, 2017

After adjustments, measurement 1 was significantly associated with risk of fall (HR 1.22, 95% CI: 1.03-1.44), fracture (HR 1.16, 95% CI: 1.01-1.34), syncope (HR 1.40, 95% CI: 1.20-1.63), and death (HR 1.36, 95% CI: 1.23-1.51). Measurement 2 was associated with all long-term outcomes, including motor vehicle crashes (HR 1.43, 95% CI: 1.04-1.96).

Repatha sBLA Under Priority Review for MACE Risk Reduction

By July 28, 2017

Results showed that the evolocumab group had a statistically significant 15% reduction (P<0.001) in the risk of extended MACE composite (primary) endpoint - which included hospitalization for unstable angina, coronary revascularization, heart attack, stroke or cardiovascular death - compared to placebo group.

Should Children with Familial Hypercholesterolemia Receive Statins?

By July 27, 2017

The researchers found that statins reduced the mean low-density lipoprotein (LDL) cholesterol concentration at all time points (moderate quality evidence).

Case Report: Severe Hypertriglyceridemia in a Young, Healthy Patient

July 26, 2017

Patient with hypertriglyceridemia had polymorphisms producing triglyceride risk score of 19

Uptravi Labeling Updated with New Contraindication, Drug Interactions

By July 25, 2017

Studies have shown that concomitant administration with gemfibrozil doubled exposure to selexipag and increased exposure to the active metabolite by approximately 11-fold.

Continuing Statin Tx After Adverse Reaction: Is It Beneficial?

July 25, 2017

Continued statin prescription linked to lower incidence of cardiovascular events and death

'Overfat' Pandemic Grows Even as Obesity Rates Level Off

July 25, 2017

Traditional methods of measuring weight or body mass index are ineffective in assessing whether a person is overfat, the study authors said.

Smoking Cessation Med Use Low in Older Patients After MI

July 21, 2017

Ninety-seven percent of smoking patients with MI received counseling, but few have SCM use

Weight Gain During Adulthood Ups Risk of Major Chronic Diseases

July 20, 2017

As little as 11 pounds gained from early to middle adulthood tied to significantly elevated risk