Calcitriol Injection Rx

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Calcitriol Injection

Secondary hyperparathyroidism or hypocalcemia
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Generic Name and Formulations:

Calcitriol 1mcg/mL; soln for IV inj.

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Indications for Calcitriol Injection:

Hypocalcemia in patients on chronic renal dialysis. Secondary hyperparathyroidism.

Adult:

≥13yrs: Initially 1–2mcg (0.02mcg/kg) 3 times weekly (approx. every other day); usual range: 0.5–4mcg 3 times weekly. May increase by 0.5–1mcg at 2–4 week intervals. Adjust dose based on PTH levels: see full labeling.

Children:

<13yrs: not recommended.

Contraindications:

Hypercalcemia. Vit. D toxicity.

Warnings/Precautions:

Avoid concurrent Vit. D therapy. Maintain adequate calcium intake. Keep serum calcium times phosphate (Ca x P) product below 70. Monitor serum calcium and phosphorus twice weekly at start of therapy, and during dose adjustment. Monitor magnesium, alkaline phosphatase, parathyroid hormone levels (PTH) periodically; if PTH levels fall <1.5–3xULN, reduce calcitriol dose or discontinue. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypermagnesemia with magnesium-containing antacids. Arrhythmias with digitalis if hypercalcemia occurs.

Pharmacological Class:

Vit. D analog.

Adverse Reactions:

Symptoms of hypervitaminosis D, hypercalcemia, hypercalciuria, hyperphosphatemia.

Note:

Formerly known under the brand name Calcijex.

How Supplied:

Contact supplier.