CAFCIT ORAL SOLUTION Rx

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CAFCIT ORAL SOLUTION

Respiratory stimulants
Only 4 drugs may be compared at once

Generic Name and Formulations:

Caffeine citrate 20mg/mL (equivalent to caffeine base 10mg/mL); preservative-free.

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Indications for CAFCIT ORAL SOLUTION:

Short-term treatment of apnea of prematurity in infants 28 to <33 weeks gestational age.

Adult:

Not applicable.

Children:

Maintenance: 5mg/kg caffeine citrate orally every 24 hours. Adjust based on response and serum caffeine levels.

Warnings/Precautions:

Measure baseline serum caffeine levels in infants previously treated with theophylline (or aminophylline) and in infants born to mothers who consumed caffeine prior to delivery. Serious toxicity may occur with serum caffeine levels >50mg/L. Exclude or treat other causes of apnea. Seizure disorders. Cardiovascular disease. Monitor caffeine levels in impaired renal or hepatic function; adjust dose to avoid toxicity. Monitor serum glucose levels and for necrotizing enterocolitis. Pregnancy (Cat.C).

Interactions:

Avoid concominant theophylline, aminophylline (increased toxicity). May be potentiated by cimetidine, ketoconazole, others (may need to reduce caffeine dose). May be antagonized by phenobarbital, phenytoin, others (may need to increase caffeine dose). Caution with CYP1A2 substrates, inhibitors, or inducers.

See Also:

CAFCIT INJECTION

Pharmacological Class:

Xanthine.

Adverse Reactions:

CNS stimulation, cardiovascular or GI effects, increased gastric aspirate, feeding intolerance, hypo- or hyperglycemia, hemorrhage, acidosis, sepsis, lung edema, dyspnea, renal effects (eg, diuresis, renal failure), necrotizing enterocolitis.

How Supplied:

Single-use vial (3mL)—1; Oral soln (3mL)—10