Breast Cancer

TFs Operate Across Gene Loci Within Disease Phenotypes

April 16, 2018

"Our results nominate mechanisms that operate across risk loci within disease phenotypes, suggesting new models for disease origins," the authors write.

Endocrine Therapy-Induced Alopecia Seen in Breast Cancer

April 12, 2018

"Endocrine therapies are associated with a pattern alopecia similar to androgenetic-type, consistent with the mechanism of action of causal agents," the authors write.

Breast Cancer Diagnosis, Therapy Differ in Women With Implants

April 04, 2018

The researchers found that palpable lesions were detected at a smaller size in augmentation patients (P<0.001) and fewer lesions were detected by screening mammography in augmented patients (P=0.010)

Incidence of Breast Cancer Investigated Among Women With Schizophrenia

March 16, 2018

The researchers included 12 cohorts (760 women) in this meta-analysis. Pooled analysis showed that schizophrenia was associated with a significantly increased risk of breast cancer incidence in women (SIR, 1.31; P<0.001).

Use of Carvedilol for Anthracycline Cardiotoxicity Prevention Investigated

March 12, 2018

Carvedilol does not prevent reduction in LVEF in breast cancer but is linked to lower troponin I levels

FDA Authorizes First Direct-to-Consumer BRCA Mutation Test

By March 06, 2018

According to a National Cancer Institute study about 2% of Ashkenazi Jewish women carry 1 of the hereditary mutations the test can detect. Among other ethnic populations this occurrence is only 0% to 0.1%.

Verzenio Gains Expanded Breast Cancer Indication

By February 27, 2018

The approval of Verzenio as initial therapy in combination with an aromatase inhibitor is based on the efficacy and safety demonstrated in the pivotal MONARCH 3 clinical trial.

Kurtosis Diffusion-Weighted Imaging May Reduce False Positive Mammographies

February 23, 2018

At the predefined sensitivity of greater than 98.0%, the researchers found that the radiomics feature model reduced false-positive results from 66 to 20 in the independent test set (specificity, 70.0%); BI-RADS 4a and 4b lesions benefited from the analysis (74.0 and 60.0%, respectively).

Induced Pluripotent Stem Cells Show Promise in Preventing Tumor Growth

February 16, 2018

The iPSC vaccine inhibited melanoma recurrence at the resection site as an adjuvant and reduced metastatic tumor load, which was correlated with fewer Th17 cells and increased CD11b+GR1hi myeloid cells.

How Strong is the Correlation Between Processed Food and Breast CA?

February 15, 2018

The researchers observed a correlation for ultra-processed food intake with increased overall cancer risk (hazard ratio for a 10% increment in the proportion of ultra-processed food in the diet, 1.12) and increased breast cancer risk (hazard ratio, 1.11)

AHA: Managing Breast CA Patients CVD Risk Requires Comprehensive Care

February 01, 2018

Current treatment for breast cancer can have a negative effect on cardiovascular health such as left ventricular dysfunction and accelerated CVD;

Investigational Metastatic Breast Cancer Tx Granted Fast Track Status

By January 25, 2018

The preliminary results found that SYD985 was well tolerated in patients previously treated with trastuzumab and ado-trastuzumab emtansine (T-DM1).

Lynparza Approved for Germline BRCA-Mutated Metastatic Breast Cancer

By January 12, 2018

It is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a "BRCA" gene mutation.

Survival Rates Assessed for Young-Onset Breast Cancer With <i>BRCA</i> Mutation

January 12, 2018

The researchers found that 12% of patients had a pathogenic BRCA mutation. Overall, 96% of the 678 deaths were due to breast cancer after a median follow-up of 8.2 years.

Breast Implants Increase Rare Type of Lymphoma

January 05, 2018

"Our results emphasize the need for increased awareness among the public, medical professionals, and regulatory bodies; promotion of alternative cosmetic procedures; and alertness to signs and symptoms of breast-ALCL in women with implants," the authors write.

Stereotactic Radiotherapy System FDA-Cleared to Treat Breast Cancer

By December 26, 2017

The GammaPod system is intended for use in the noninvasive stereotactic delivery of a radiation dose to a portion of the breast in conjunction with breast conserving treatment.

Perjeta Gains New Indication for Early Breast Cancer

By December 21, 2017

Approval was based on data from APHINITY, a multicenter, randomized, double-blind, placebo-controlled trial in 4804 patients with HER2-positive early breast cancer who had their primary tumor excised prior to randomization.

First Dose-Escalation Study Examines Ulixertinib for Advanced Tumors

December 18, 2017

The researchers found that ulixertinib exposure was dose-proportional to the RP2D and almost completely inhibited ERK activity in whole blood.

Accuracy of Artificial Intelligence Assessed in CA Diagnosis

December 12, 2017

The researchers found that the AUC of the DLS for referable diabetic retinopathy was 0.936, and sensitivity and specificity were 90.5 and 91.6%, respectively

Acupuncture May Relieve Aromatase Inhibitor-Linked Joint Pain

December 08, 2017

The researchers found that the 6-week mean BPI worst pain scores were 0.92 points lower in the true acupuncture versus sham acupuncture arm, and 0.96 points lower in the true acupuncture versus waitlist control arm.

Kisqali Shows Promise in Premenopausal Breast CA Population

By December 08, 2017

Results found a median PFS of 23.8 months (95% CI: 19.2 months-not reached) for the Kisqali group compared to 13.0 months (95% CI: 11.0-16.4 months) for tamoxifen or an aromatase inhibitor plus goserelin (HR=0.553; 95% CI: 0.441-0.694; P<0.0001).

'No Rationale' for Extended Anastrozole Tx in HR&#43; Early Breast CA, Study Finds

December 08, 2017

"There is simply no rationale to keep most patients on extended aromatase inhibitor for longer than two years," said lead author Michael Gnant in a statement.

Hormonal Contraceptives and Breast Cancer: What's the Link?

December 07, 2017

Findings from nationwide study in Denmark show small absolute increase in breast cancer risk

Ribociclib Addition Assessed for PFS in HR&#43; HER2&#8722; Advanced Breast CA

December 07, 2017

Researchers conducted a randomized phase III trial assessing ribociclib + tamoxifen/non-steroidal aromatase inhibitor and goserelin in pre- and peri-menopausal women.

FDA Approves Second Biosimilar for the Treatment of Cancer

By December 01, 2017

Ogivri is the first biosimilar approved in the U.S. for the treatment of breast cancer or stomach cancer and the second biosimilar approved in the U.S. for the treatment of cancer.

Faslodex Approved as Combo Tx for Advanced Breast Cancer

By November 15, 2017

The FDA approval is based on data from the Phase 3 MONARCH 2 trial, which met the study's primary endpoint of PFS.

Breast Cancer Recurrences Steady After Therapy Cessation

November 10, 2017

The risk of distant recurrence was 13, 20, and 34%, respectively, among patients with stage T1 disease with no nodal involvement (T1N0), with one to three nodes involved (T1N1-3), and with 4 to 9 nodes involved (T1N4-9).

Adipocytes May Clear Daunorubicin, Contribute to Poorer Survival Outcomes

November 09, 2017

The researchers found that adipocytes absorbed and metabolized daunorubicin to daunorubicinol, which reduced its anti-leukemia effect. Daunorubicin conversion to daunorubicinol was confirmed in vivo in murine studies.

Experts Pick the Top 10 Medical Innovations for 2018

By November 03, 2017

The panel - made up of nearly 100 physicians and scientists - debated and whittled down over 150 nominations to decide upon the final 10.

Xenografts Show Therapeutic Potential for PARP Inhibitors Beyond <i>BRCA1/2</i>

November 02, 2017

Researchers generated 26 breast cancer patient-derived xenografts (PDXs) from surgical samples of primary or locally recurrent tumors from 25 patients.