Generic Name for BONIVA
Ibandronate (as monosodium monohydrate) 150mg; tabs.
Legal Classification:
Rx
Pharmacological Class for BONIVA
Bisphosphonate.
Manufacturer of BONIVA
Roche Laboratories
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Indications for BONIVA
Prevention and treatment of postmenopausal osteoporosis.
Adult dose for BONIVA
Swallow whole. Take in the AM with plain (not mineral) water (6–8oz), at least 60 minutes before the first food, drink, or medication of the day; do not lie down for at least 60 minutes after. 150mg once monthly (take on the same day each month). Do not take two 150mg tablets within the same week.
Children's dosing for BONIVA
Not recommended.
Also:
Contraindications for BONIVA
Hypocalcemia. Tabs: Esophagus abnormalities which delay esophageal emptying (eg, stricture, achalasia). Inability to stand or sit upright for at least 60 minutes.
Warnings/Precautions for BONIVA
Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Severe renal impairment (CrCl <30mL/min): not recommended. Correct preexisting hypocalcemia, other mineral or bone disturbances before starting. History of bisphosphonate exposure: evaluate for atypical fractures if thigh/groin pain develops; consider withholding therapy until risk/benefit assessment. Ensure adequate Vit. D and calcium intake. Reevaluate periodically. Inj: check renal function before each dose. Pregnancy (Cat.C). Nursing mothers.
Interactions for BONIVA
Calcium, aluminum, magnesium, other divalent cations reduce absorption (separate dosing). Caution with aspirin, NSAIDs, other GI irritants. May interfere with bone-imaging agents. Concomitant nephrotoxic agents; monitor for renal toxicity.
Adverse Reactions for BONIVA
GI upset, abdominal pain, musculoskeletal pain (may be severe), headache; dysphagia, esophagitis, esophageal or gastric ulcer, jaw osteonecrosis; atypical femur fractures. Inj: inj site reactions, flu-like syndrome.
How is BONIVA supplied?
Tabs 150mg—3; Prefilled syringe (5mL)—1 (w. supplies)