Bone Disorders

CombiPatch, Minivelle Patches No Longer in Shortage

By October 03, 2017

Noven announced that CombiPatch (estradiol/norethindrone acetate transdermal system) and Minivelle (estradiol transdermal system) are now readily available following a temporary product shortage.

Romosozumab Followed by Alendronate Superior in Reducing Fracture Risk

By September 12, 2017

ARCH (Active-contRolled FraCture Study in Postmenopausal Women with Osteoporosis at High Risk of Fracture) was a multicenter, international, randomized, double-blind, alendronate-controlled study (n=4,093) in postmenopausal women with osteoporosis at high risk for fracture based on previous fracture history.

Fracture Risk Reduced with Abaloparatide Followed by Alendronate

By September 11, 2017

The data showed a statistically significant fracture risk reduction through 3.5 years.

Alendronate Safe, Effective in Elderly Patients with Prior Fracture

September 07, 2017

Alendronate treatment reduced risk of hip fracture with sustained safety

Necessity of Opioid Rx Examined Post-Hernia Repair

August 15, 2017

The researchers found that 85.9% of patients reported using four or fewer opioid tablets, with 59.5% reporting that they used no opioid analgesics postoperatively.

Osteoporosis Drugs Assessed for Secondary Fracture Prevention

By August 10, 2017

Results showed a significant reduction in the risk for secondary vertebral fracture with all of the of anti-osteoporotic drugs (risk ratio [RR] 0.38-0.77).

Osteoporosis Med Efficacy Assessed in Nonmetastatic Prostate CA

August 09, 2017

The researchers found that BMD was effectively increased with bisphosphonates, but no trial was sufficiently powered to detect a decrease in fractures.

Vitamin B Effects on Fracture Risk Examined in Women at High CVD Risk

August 07, 2017

The researchers found that B vitamin supplementation had no significant effect on non-spine fracture risk (relative hazard, 1.08; 95% confidence interval, 0.88 to 1.34).

FDA Requests More Data for Unique Osteoporosis Drug Candidate

By July 17, 2017

Dr. Pascale Richetta, head of bone and executive vice president, UCB, stated, "With all three pivotal romosozumab Phase 3 studies now included in the clinical evidence package, representing data from more than 11,000 patients, we are committed to bringing this important potential new treatment to those people living at risk of fragility fractures."

Research Paper Reviews JFK's Chronic Health Issues

By July 14, 2017

A new review published in the Journal of Neurosurgery: Spine details the health issues that troubled JFK the most, specifically his back. His low-back pain was instigated by a football injury sustained while he was at Harvard in 1937. An orthopedic spine specialist diagnosed him in 1940 with a "very unstable lumbosacral joint".

Early ART Start Linked to Bone Loss in HIV Patients

By June 27, 2017

Over the 2.2 years mean follow-up, the immediate ART arm demonstrated greater BMD declines vs. the deferred ART arm at the hip (-2.5% vs. -1.0%, 95% CI: -2.2 to -0.8; P<0.001) and at the spine (-1.9% vs. -0.4%, 95% CI: -2.2 to -1.0; P<0.001).

Pooled Safety Analysis Finds Jardiance Well Tolerated

By June 14, 2017

The proportion of study patients with lower limb amputations were similar for Jardiance (1.9%) and placebo groups (1.8%).

Do Certain B-Vitamins Increase Hip Fracture Risk?

June 12, 2017

But no significant link for vitamin B12 and risk of hip fracture during trial and extended follow-up

Antidepressant Linked to Accelerated Bone Loss

June 06, 2017

The researchers found that during venlafaxine treatment there was an increase in CTX and a decrease in P1NP, which was consistent with accelerated bone loss.

AACE/ACE: New ACP Osteoporosis Guidelines 'Fall Short'

By May 19, 2017

Five important differences were identified by AACE/ACE involving pharmacotherapy choice as well as treatment duration and reevaluation.

Are Corticosteroid Injections Beneficial for Knee Osteoarthritis?

May 17, 2017

The researchers found that at the end of the study, pain levels didn't differ significantly between the patient who received intra-articular triamcinolone or saline.

ACP: Low Bone Density, Osteoporosis Treatment Recommendations

May 12, 2017

Osteoporotic women should be treated with pharmacologic therapy for 5 years to cut fracture risk

Hip Fracture Risk Up in New Users of Sleep Aids

May 03, 2017

New users of sleep aids have fracture rate 2.5 times greater than peers not taking these drugs

Bone Building Drug Gets FDA Approval for Osteoporosis

By April 28, 2017

Abaloparatide is a parathyroid hormone related peptide [PTHrP(1-34)] analog which acts as an agonist at the PTH1 receptor (PTH1R). This results in activation of the cAMP signaling pathway in target cells.

Music Therapy Relieves Post-Op Pain in Spinal Surgery Patients

April 10, 2017

Researchers provided 30 patients who'd had spinal fusion surgery with a 30-minute music therapy session within 72 hours of their operation, while another group received only standard care after their procedure.

Postmenopausal Osteoporosis Drug Shows Long-Term Safety

By April 10, 2017

Researchers evaluated the incidences of adverse events in women who initially received placebo during the FREEDOM trial and then received denosumab for up to 3 years during the FREEDOM Extension trial.

Amgen Looks to Expand Xgeva Use to Multiple Myeloma Patients

By April 05, 2017

The study met its primary endpoint of Xgeva non-inferiority versus zoledronic acid in delaying the time to first on-study SRE in multiple myeloma patients (HR=0.98, 95% CI: 0.85, 1.14; P=0.01).

Amount of Vitamin D Needed May Be Less than What's Recommended

By April 03, 2017

"This has important ramifications for public health recommendations," said Christopher Gallagher, MD, professor and director of the Bone Metabolism Unit in the Division of Endocrinology of Creighton University School of Medicine.

Experimental Device Helps Paralyzed Man Feed Himself

March 29, 2017

Researchers utilized functional electric stimulation intracortical brain-computer interface system

Is Direct Home Discharge Better for Arthroplasty Recovery?

March 17, 2017

One study found that patients who are discharged directly home following a total knee arthroplasty face a lower risk for complications and hospital readmission than those who first go to an inpatient rehab facility.

Death More Likely in Men After Osteoporosis-Related Fracture

March 16, 2017

Researchers analyzed data from more than 1.6 million Americans, aged 65 and older, who had osteoporosis and experienced a fracture between 2005 and 2009.

SSRI Use Tied to Improved Joint Replacement Sx Outcomes

By March 14, 2017

SSRIs users had significantly lower risk of revisions and aseptic revisions compared to those who were not administered an SSRI.

Testosterone Trials Show Short-Term Benefits but CV Risk Still Unclear

February 22, 2017

While trials show it boosts bone density and lowers anemia risk, heart risks also seen

Shift in Bisphosphonate Use with Revised Osteoporosis Recommendations

February 10, 2017

In response to revised osteoporosis recommendations in 2008, there was a shift in age-related trends in oral bisphosphonate (BP) therapy initiation, according to a study published online February 2 in the Journal of the American Geriatrics Society.

New Position Paper on Screening for Osteoporosis Therapy Adherence Published

By January 30, 2017

The International Osteoporosis Foundation and European Calcified Tissue Society Working Group proposed a screening strategy measuring certain bone turnover markers in patients who have initiated oral bisphosphonate therapy for postmenopausal osteoporosis as a practical way to identify low adherence.