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BANZEL ORAL SUSPENSION to:
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Generic Name for BANZEL ORAL SUSPENSION
Rufinamide 40mg/mL; orange-flavor; lactose-, gluten-, and dye-free.
Legal Classification:
Rx
Pharmacological Class for BANZEL ORAL SUSPENSION
Antiepileptic (triazole).
Manufacturer of BANZEL ORAL SUSPENSION
Eisai Pharmaceuticals
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Indications for BANZEL ORAL SUSPENSION
Adjunctive treatment of seizures in Lennox-Gastaut syndrome.
Adult dose for BANZEL ORAL SUSPENSION
Take with food in 2 equally divided doses. Initially 400–800mg per day; increase by 400–800mg/day every other day to target of 3200mg/day. Avoid abrupt cessation (reduce dose by 25% every 2 days).
Children's dosing for BANZEL ORAL SUSPENSION
Take with food in 2 equally divided doses. <4yrs: not recommended. ≥4yrs: initially 10mg/kg per day; increase every other day by 10mg/kg to target 45mg/kg per day or 3200mg/day (whichever is less). Avoid abrupt cessation (reduce dose by 25% every 2 days).
Also:
Contraindications for BANZEL ORAL SUSPENSION
Familial short QT syndrome.
Warnings/Precautions for BANZEL ORAL SUSPENSION
Severe hepatic impairment: not recommended. Mild to moderate hepatic impairment. Dialysis (may adjust dose). Depression or suicidal ideation (monitor). Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for BANZEL ORAL SUSPENSION
Caution with drugs that shorten QT interval. CNS depression with alcohol, other CNS depressants. Antagonizes carbamazepine, lamotrigine, triazolam. May potentiate phenobarbital, phenytoin. Potentiated by valproate (reduce doses). Antagonized by carbamazepine, phenobarbital, primidone, phenytoin. May affect substrates of CYP3A4, CYP2E1 (monitor). Antagonizes hormonal contraceptives (use non-hormonal forms too). May be affected by inducers or inhibitors of carboxylesterases.
Adverse Reactions for BANZEL ORAL SUSPENSION
Somnolence, fatigue, incoordination, dizziness, gait disturbances, ataxia, headache, GI upset, visual disturbances, leukopenia, fever/rash (monitor for multi-organ hypersensitivity reactions; discontinue if occur).
How is BANZEL ORAL SUSPENSION supplied?
Tabs 200mg—30; 400mg—120; susp—460mL (w. adapter & dosing syringe)