Of the 63 patients with available information who became ill between, 34 have been hospitalized. No deaths have been reported. Illnesses have been reported in Illinois (7), Indiana (11), Kentucky (1), Michigan (38), Missouri (10), Ohio (2), and Tennessee (1).
ACX-362E is a targeted, narrow spectrum oral antibiotic that blocks the DNA replication process through inhibition of polymerase III, which has been shown to be bactericidal.
Although all of the guidelines acknowledge that there are emergent situations in which providing care for a family member or friend is not only permissible but also essential, other situations are frowned upon.
The NDA includes safety and efficacy data from two Phase 3 trials (REVIVE-1 and REVIVE-2; N=1190) which compared intravenous iclaprim to standard-of-care vancomycin in patients with ABSSSI.
The cereal under recall includes Honey Smacks 15.3 oz. size with the UPC code of 3800039103 and a Best if Used by Date of JUN 14, 2018, through JUN 14, 2019. Also included are Honey Smacks in the 23 oz. size with the same "Best Before" date and the UPC code of 3800014810.
The researchers found that the crude proportion of cephalosporin-resistant (CephR) A. baumannii increased from 13.2% in 1999 to 23.4% in 2012, with a peak of 32.5% in 2008. Similarly, the proportion of carbapenem(CR)-resistant A. baumannii increased from 0.6% in 1999 to 6.1% in 2012, peaking at 12.7% in 2008.
Of the 60 patients who became ill between April 30, 2018, and May 30, 2018, 31 have been hospitalized. The patients range in age from 1 to 97 years.
Violations included entering rooms without some or all recommended PPE; during PPE removal, mistakes were frequently observed, as well as during encounters with challenging logistical situations, such as badge-enforced computer logins.
Compared with single-use towels, multipurpose towels had higher colony-forming units (CFUs); humid towels had higher CFUs than dry ones. The mean CFU was 2.76 × 105, and was significantly higher from cotton versus nylon and mixture of both towels.
The researchers found that the likelihood of developing invasive MRSA infections was 16.3 times higher for persons who inject drugs versus others.
For patients at hospitals in the second, third, and fourth quartiles, the odds of in-hospital death for immunosuppressed patients with sepsis relative to non-immunosuppressed patients with sepsis was similar.
In total, 197 cases of illness tied to the E. coli O157:H7 strain of bacteria were linked to tainted romaine lettuce, with cases spread across 35 states.
The final guidance clarifies that drugs developed for inhalational anthrax prophylaxis can rely on evidence from animal studies (the Animal Rule) to support approval when the criteria under the Animal Rule have been met.
In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.
PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.
A Phase 3 clinical trial of patients with travelers' diarrhea demonstrated that Aemcolo was superior to placebo (P=.0008) and non-inferior to ciprofloxacin.
Dr Vincent also states that target groups should be considered in vaccine development and adds, "It is generally thought that the best target group would be girls and boys aged 9-13, preferably before sexual debut, similar to the HPV vaccination program."
In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days
Mecillinam is a beta-lactam antibiotic with a novel site of action which is specific and highly active against Gram-negative bacteria.
As a result of the tests, the FDA is advising consumers and clinicians to avoid using all lots of Remedy Essentials No-Rinse Cleansing Foam.
The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.
Most cases were insured by federal and/or state programs (73.6 and 10.1%, respectively), but many (44.9%) patients were considered under-insured. In 2015, hospital charges of $4,580,786.88 were identified for the 66 cases of illicit drug-associated endocarditis.
The Breakthrough designation was based on data from Phase 2 studies which assessed the safety and efficacy of the vaccine in this patient population.
The study reports the development of a clinical and biochemical prediction tool for assessing the risk of urinary tract infection in preverbal children with fever. The model developed accurately predicted which patients may need further testing based on clinical variables, and who may need antibiotics therapy based on urine analysis supplement.
Factors associated with C. difficile infection incidence in the 30-day postoperative period after controlling for other variables include stoma reversal (odds ratio, 2.701; P<.001), smoking (odds ratio, 1.520; P<.022), steroids (odds ratio, 1.677; P<.048), and disseminated cancer.