Bacterial Infections

Celiac Disease Linked to Increased Risk of Pneumococcal Infection

By August 15, 2017

After adjusting for socioeconomic index, diabetes, level of education, sex and age, an increased risk of pneumococcal infection among celiac disease patients was noted.

Efficacy of Killed Whole-Cell Oral Cholera Vaccine Examined

August 14, 2017

During the 2 years after vaccination the 2-dose efficacy estimates were similar, with estimates of 56 and 59% in the first and second year, respectively.

NDA Submitted for Non-Cystic Fibrosis Bronchiectasis Treatment

By August 11, 2017

Linhaliq (previously known as 'Pulmaquin') consists of a mixture of liposome encapsulated and unencapsulated ciprofloxacin. Linhaliq has previously been granted Orphan Drug status for the management of bronchiectasis.

Gastroenteritis Hospitalizations Down with Rotavirus Vaccine Introduction

August 11, 2017

The researchers found that 16% of the 1,253,951 AGE-related hospitalizations among children aged <5 years were coded as a rotavirus-related hospitalization.

CVD Risk Significantly Heightened in Years Follow Severe Infection

August 09, 2017

While the first year after infection has the highest risk (adjusted hazard ratio [aHR], 6.33), an increased risk persists for the second (aHR, 2.47) and third year (aHR, 2.12) after infection.

Preventive Treatments for Recurrent Cellulitis Investigated

August 07, 2017

"Larger, high-quality studies are warranted, including long-term follow-up and other prophylactic measures," the authors write.

Stool Softeners Recalled Due to Possible Contamination

By August 03, 2017

Rugby Laboratories announced a voluntary recall of all lots of Diocto Liquid and Diocto Syrup (docusate sodium solutions) due to a risk of contamination with Burkholderia cepacia.

Guaifenesin/Pseudoephedrine Intervention May Cut Antibiotic Rxs for Acute URTI

By August 03, 2017

Results found that at day 8 of the study, a significantly lower amount of patients receiving guaifenesin/pseudoephedrine desired antibiotics compared to placebo, 4.2% vs. 8.0%, respectively.

Publication of Drug Interaction Unlikely to Impact Prescribing Patterns

By August 02, 2017

The findings point to "minimal to no measurable effect" in lowering the concomitant use.

Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition

By August 01, 2017

For this study, the researchers examined data from the LifeLink Database for cases with ICD-9-CM code for benign intracranial hypertension (BIH) as well as an MRI or CT scan and a lumbar puncture within 15 or 30 days of the BIH code.

Septic Arthritis Outbreak Highlights Need for Better Infection Prevention in Outpatient Settings

By July 27, 2017

Recovered organisms included various Streptococcus, Actinomyces, Haemophilus, Neisseria species, among others; all of the pathogens isolated were oral flora. Two patients also exhibited Staphylococcus aureus bacteria in the blood.

Vaccine for Recurrent UTI Granted Fast Track Designation

By July 26, 2017

The vaccine consists of the FimH bacterial adhesion protein as well as a new adjuvant designed to induce an immune response to prevent bacterial colonization of the urinary tract.

Investigational Antibiotic Combo Beats Best Available Tx for CRE

By July 26, 2017

Patient randomization was discontinued early after an independent Data and Safety Monitoring Board (DSMB) determined that a risk-benefit analysis (n=72) of available data no longer necessitated additional patient randomization to the comparator arm (best available therapy).

Cephalosporin Antibiotic Formulation Discontinued

By July 24, 2017

Specifically, the following presentations will no longer be available: 125mg/5mL; 100mL bottles (anticipated final date of availability: April 1, 2018), 250mg/5mL; 50mL bottles (anticipated final date of availability: January 15, 2018), 250mg/5mL; 100mL bottles (anticipated final date of availability: February 15, 2018)

Lyme Disease Vaccine Gets Fast Track Status

By July 24, 2017

Additionally, the study will measure immunogenicity against the 6 most prevalent serotypes of Lyme borreliosis present in the vaccine.

Antibiotics During Pregnancy and Birth Defects: What's the Link?

By July 19, 2017

The data showed in utero exposure to clindamycin was associated with a higher risk of MCMs (adjusted odds ratio [aOR] 1.34, 95% CI: 1.02-1.77), musculoskeletal system malformations (aOR 1.67, 95% CI: 1.12-2.48), and ventricular/atrial septal defect (aOR 1.81, 95% CI: 1.04-3.16).

Study Shows Zero Occurrences of Stethoscope Hygiene Between Patients

By July 19, 2017

Even after the intervention, of 41 subsequent observations, the researchers still noted zero occurrences of stethoscope hygiene. Hand hygiene did increase but only slightly, to 63%.

Recall Announced for Meningitis Vaccine

By July 19, 2017

This recall is considered precautionary as the batch associated with the recall was subject to a "mechanical intervention executed during the aseptic filling operations, which is not supported by validation data."

Many Unaware of Increased Tick Threat This Season

July 17, 2017

"Perhaps the most important finding is that three-quarters of the public are not aware of reports of a sizable increase in the number of ticks this summer," said Humphrey Taylor, chairman of The Harris Poll.

Rise in Syphilis Cases Prompts New CDC Video for Clinicians

By July 12, 2017

The CDC's efforts are focused on talking, testing and treating.

Gonorrhea Vaccine May Be One Step Closer to Reality

July 11, 2017

First time vaccine has shown any protection against gonorrhea, researchers report

WHO: Resistance to Last-Resort Gonorrhea Tx Seen in 66% of Countries

By July 10, 2017

Gonorrhea is a sexually transmitted infection (STI) that can affect the genitals, rectum, and throat. Complications include pelvic inflammatory disease, ectopic pregnancy, infertility, and an increased risk of HIV.

Eculizumab Linked to High Risk of Meningococcal Disease, Despite Vaccination

By July 10, 2017

In vitro data have shown that eculizumab impairs meningococcal killing in whole blood despite patients being vaccinated against the appropriate serogroup. The current vaccines against meningococcal disease only target serogroup-specific proteins and do not provide protection against nongroupable N. meningitidis.

Drug Tampering by Healthcare Worker Causes Outbreak at Hospital

By July 07, 2017

The investigation found that that the nurse had replaced the active medication with saline or another solution. All of the patients recovered except one who died from a sepsis infection.

New Antibiotic Designated QIDP for Two Indications

By June 29, 2017

The gel is hormone-free and can be used with other forms of contraception or used alone. The gel, supplied in a pre-filled applicator, can be self-applied.

Pre-Admission Antibiotic Use Studied in Meningococcal Disease

By June 28, 2017

Researchers analyzed 1 open-label, non-inferiority RCT (n=510), which was conducted during an epidemic in Niger. The trial evaluated a single dose of intramuscular ceftriaxone vs. a single dose of intramuscular long-acting (oily) chloramphenicol.

Advanced Pharma Initiates Recall Following Hospira Recall Announcement

By June 23, 2017

The use of contaminated product may cause adverse events such as fever, chills and malaise; more serious adverse events include systemic bacterial sepsis and systemic invasive mycoses.

Does Asthma Inadvertently Protect Against Life-Threatening Infections?

June 23, 2017

The researchers found that patients with asthma had decreased risk for hospital mortality, septicemia, sepsis, severe sepsis, and septic shock (adjusted odds ratios, 0.41, 0.60, 0.59, 0.60, and 0.74, respectively) across all infections in the 2012 NIS data.

Nephron Pharma Responds to Sodium Bicarbonate Shortage

By June 22, 2017

Nephron Pharmaceuticals has joined the effort to abate the nationwide shortage of Sodium Bicarbonate 8.4% by tripling its production of the injectable syringes.

New Antibiotic Baxdela Gets FDA Approval

By June 19, 2017

Baxdela, a fluoroquinolone antibiotic, is active against both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus.