Bacterial Infections

CDC: Salmonella-Tainted Melon Outbreak Continues to Expand

June 21, 2018

Of the 63 patients with available information who became ill between, 34 have been hospitalized. No deaths have been reported. Illnesses have been reported in Illinois (7), Indiana (11), Kentucky (1), Michigan (38), Missouri (10), Ohio (2), and Tennessee (1).

Novel Antibiotic for <i>C. Difficile</i> Infection Gets FDA's QIDP Designation

By June 20, 2018

ACX-362E is a targeted, narrow spectrum oral antibiotic that blocks the DNA replication process through inhibition of polymerase III, which has been shown to be bactericidal.

Should Physicians Treat Family and Friends? Three Experts Weigh In

By June 19, 2018

Although all of the guidelines acknowledge that there are emergent situations in which providing care for a family member or friend is not only permissible but also essential, other situations are frowned upon.

NDA Submitted for Novel, Targeted Antibiotic Iclaprim

By June 18, 2018

The NDA includes safety and efficacy data from two Phase 3 trials (REVIVE-1 and REVIVE-2; N=1190) which compared intravenous iclaprim to standard-of-care vancomycin in patients with ABSSSI.

Kellogg's Honey Smacks Cereal Recalled Due to <i>Salmonella</i> Risk

June 18, 2018

The cereal under recall includes Honey Smacks 15.3 oz. size with the UPC code of 3800039103 and a Best if Used by Date of JUN 14, 2018, through JUN 14, 2019. Also included are Honey Smacks in the 23 oz. size with the same "Best Before" date and the UPC code of 3800014810.

Resistant <i>A. Baumannii</i> Rose in Children From 1999 to 2012

June 18, 2018

The researchers found that the crude proportion of cephalosporin-resistant (CephR) A. baumannii increased from 13.2% in 1999 to 23.4% in 2012, with a peak of 32.5% in 2008. Similarly, the proportion of carbapenem(CR)-resistant A. baumannii increased from 0.6% in 1999 to 6.1% in 2012, peaking at 12.7% in 2008.

Sixty Sickened so Far in Salmonella-Tainted Melon Outbreak

June 14, 2018

Of the 60 patients who became ill between April 30, 2018, and May 30, 2018, 31 have been hospitalized. The patients range in age from 1 to 97 years.

Active Failures Seen in Proper Use of Personal Protective Equipment

June 12, 2018

Violations included entering rooms without some or all recommended PPE; during PPE removal, mistakes were frequently observed, as well as during encounters with challenging logistical situations, such as badge-enforced computer logins.

Kitchen Towels Are Source of Possibly Pathogenic Bacteria

June 12, 2018

Compared with single-use towels, multipurpose towels had higher colony-forming units (CFUs); humid towels had higher CFUs than dry ones. The mean CFU was 2.76 × 105, and was significantly higher from cotton versus nylon and mixture of both towels.

CDC: Invasive MRSA More Likely Among Injection Drug Users

June 12, 2018

The researchers found that the likelihood of developing invasive MRSA infections was 16.3 times higher for persons who inject drugs versus others.

Case Volume Affects Mortality for Immunosuppressed With Sepsis

June 08, 2018

For patients at hospitals in the second, third, and fourth quartiles, the odds of in-hospital death for immunosuppressed patients with sepsis relative to non-immunosuppressed patients with sepsis was similar.

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

By June 04, 2018

PJI is a challenging complication of joint arthroplasty with few effective treatment options.

CDC Says <i>E. Coli</i> Outbreak Tied to Romaine Lettuce Is Over

June 04, 2018

In total, 197 cases of illness tied to the E. coli O157:H7 strain of bacteria were linked to tainted romaine lettuce, with cases spread across 35 states.

FDA Issues Final Guidance on Inhalational Anthrax

June 01, 2018

The final guidance clarifies that drugs developed for inhalational anthrax prophylaxis can rely on evidence from animal studies (the Animal Rule) to support approval when the criteria under the Animal Rule have been met.

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

By May 29, 2018

In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

By May 24, 2018

PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

FDA to Review Aemcolo for Treatment of Travelers' Diarrhea

By May 23, 2018

A Phase 3 clinical trial of patients with travelers' diarrhea demonstrated that Aemcolo was superior to placebo (P=.0008) and non-inferior to ciprofloxacin.

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

May 23, 2018

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Need for Gonorrhea Vaccine Highlighted in Light of Global Disease Burden

By May 22, 2018

Dr Vincent also states that target groups should be considered in vaccine development and adds, "It is generally thought that the best target group would be girls and boys aged 9-13, preferably before sexual debut, similar to the HPV vaccination program."

Positive Results Announced for Pleuromutilin Antibiotic in CABP

By May 22, 2018

In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days

Mecillinam/Pivmecillinam Get QIDP Designation for Complicated UTI

By May 21, 2018

Mecillinam is a beta-lactam antibiotic with a novel site of action which is specific and highly active against Gram-negative bacteria.

IV Combo Antibiotic Recalled Due to Potential for Decreased Potency

By May 15, 2018

The 36 recalled lots were manufactured by Hospira and marketed by Apotex.

<i>B. cepacia</i> Outbreak Tied to No-Rinse Cleansing Foam

By May 11, 2018

As a result of the tests, the FDA is advising consumers and clinicians to avoid using all lots of Remedy Essentials No-Rinse Cleansing Foam.

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

By May 03, 2018

The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.

Drug-Related Endocarditis Cases Up From 2007 to 2015

April 27, 2018

Most cases were insured by federal and/or state programs (73.6 and 10.1%, respectively), but many (44.9%) patients were considered under-insured. In 2015, hospital charges of $4,580,786.88 were identified for the 66 cases of illicit drug-associated endocarditis.

MenB Vaccine Gets Breakthrough Tx Designation for Kids Ages 1 to 9 Years

By April 23, 2018

The Breakthrough designation was based on data from Phase 2 studies which assessed the safety and efficacy of the vaccine in this patient population.

Prediction tool for urinary tract infections in preverbal children

April 23, 2018

The study reports the development of a clinical and biochemical prediction tool for assessing the risk of urinary tract infection in preverbal children with fever. The model developed accurately predicted which patients may need further testing based on clinical variables, and who may need antibiotics therapy based on urine analysis supplement.

<i>C. Difficile</i> Risk Higher With Stoma Reversal vs Difficile

April 18, 2018

Factors associated with C. difficile infection incidence in the 30-day postoperative period after controlling for other variables include stoma reversal (odds ratio, 2.701; P<.001), smoking (odds ratio, 1.520; P<.022), steroids (odds ratio, 1.677; P<.048), and disseminated cancer.

Review: Treatment Recommendations for Biological Disasters

By April 17, 2018

The Centers for Disease Control and Prevention (CDC) classifies key biological agents into three categories: A, B, and C.

It Costs &#36;2.2 Billion a Year to Treat Antibiotic Resistance

April 16, 2018

Antibiotic resistance adds 1,383 to the cost of treating a bacterial infection