Bacterial Infections

FDA: Antibiotic Linked to Increased Risk of Death in Heart Disease Patients

By February 22, 2018

The Agency is asking healthcare professionals to use caution before prescribing the antibiotic to this patient population.

SEP-1 Interventions May Not Improve Survival in Sepsis

February 22, 2018

The researchers found that in one single-center observational study, lower in-hospital mortality was reported after implementation of the SEP-1 bundle. Increased survival was seen with serial lactate measurement or 30-mL/kg fluid infusions based on data from 16 studies (2 randomized and 14 observational).

Multistate <i>Salmonella</i> Outbreak Linked to Controversial Supplement

By February 21, 2018

A total of 28 people from 20 states have been infected with the outbreak strain of Salmonella.

How Do HCPs Feel About Patient Involvement in Hygiene Initiatives?

February 16, 2018

Based on 19 papers, the researchers found that patients were willing to remind health care professionals, especially nurses, to wash their hands. However, health care professionals' perception toward patient involvement varied from study to study.

Opioid Use May Increase the Risk for Invasive Pneumococcal Disease

February 13, 2018

Strongest associations seen for opioids that were long acting, of high potency, and used at high doses

USPSTF: Screening for Syphilis in Pregnant Women Beneficial

February 07, 2018

Draft recommendation indicates considerable net benefit to screening for syphilis infection

Avycaz Approved for Hospital-Acquired and Ventilator-Associated Pneumonia

By February 02, 2018

Avycaz is a first-in-class cephalosporin + beta-lactamase inhibitor.

Risk of Appendicitis Measured Following Colonoscopy

January 31, 2018

More frequent codes for appendicitis, appendectomy in week after colonoscopy versus next 51 weeks. This result was not affected by age subgrouping, and there was no increase in appendicitis in weeks two to four.

Firvanq Approved for <i>C. difficile</i>-Associated Diarrhea, <i>S. aureus</i> Colitis

By January 29, 2018

Firvanq oral solution will replace CutisPharma's FIRST-Vancomycin Unit-of-Use Compounding Kit, which was used by pharmacists to compound vancomycin oral liquid.

Baxdela Available to Treat Acute Bacterial Skin/Skin Structure Infections

By January 29, 2018

Baxdela is indicated in adults for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates.

Toxic Shock Syndrome Requires Prompt Recognition, Treatment

By January 24, 2018

Early symptoms of TSS include fever, chills, malaise, rash, vomiting, diarrhea, and hypotension.

Nitrofurantoin, TMP-SMX Often Prescribed in Early Pregnancy for UTI

By January 17, 2018

A 2011 committee opinion from the American College of Obstetricians and Gynecologists (ACOG) recommended that sulfonamides and nitrofurantoin may be prescribed in the first trimester of pregnancy only when other antimicrobial therapies are deemed clinically inappropriate.

Risk of Bacterial Infection Assessed in Febrile Infants With Human Rhinovirus

January 17, 2018

Overall, 9.5% had bacterial infection. The likelihood of bacterial infection was increased for febrile infants with HRV detected versus those with non-HRV viruses (7.8 versus 3.7%; relative risk, 2.12).

Urinalysis highly sensitive and specific for UTI in febrile infants

January 16, 2018

Urinalysis had ≥90% sensitivity and specificity in identifying urinary tract infection (UTI) among infants ≤60 days old with fever, regardless of presence of associated bacteremia.

Incidence, Interventions Examined for Non-Ventilator Hospital-Acquired Pneumonia

January 16, 2018

The majority of NV-HAP infections (70.8%) were acquired outside of ICUs, but 18.8% of cases required transfer into the ICU.

CDC Publishes Map Detailing Antibiotic Resistance Investments, Successes

January 12, 2018

For fiscal year 2017, successes displayed in the map include rapid isolation of a patient with a rare infection, with the containment protocol executed within 48 hours in Tennessee, and reduction of carbapenem-resistant Enterobacteriaceae by 30% in 40 facilities in Michigan.

Contact Precaution Guidelines Released for Multidrug-Resistant Infections

By January 11, 2018

The guidance was authored by members of the SHEA Guidelines Committee, which consists of experts in infection control and prevention.

Surgery or Antibiotics? Patient Preference Assessed in Uncomplicated Appendicitis

January 11, 2018

The researchers found that 85.8% of survey respondents chose laparoscopic appendectomy for themselves, and 4.9 and 9.4% chose open appendectomy and antibiotics alone, respectively.

Deadly <i>E. coli</i> Outbreak Has Officials in U.S. Searching for Source

By January 05, 2018

A similar outbreak of STEC O157:H7 has occurred in Canada; The Public Health Agency of Canada (PHAC) has pinpointed romaine lettuce as the source.

Could a Widely Used Food Additive Be Contributing to Epidemic <i>C. difficile</i>?

By January 05, 2018

Implementation of trehalose as a food additive into the human diet may have contributed to hypervirulence.

Injectable Antibiotic Combo Recalled Due to Glass Particles

By January 04, 2018

The administration of a glass particulate may result in local irritation or swelling in response to the foreign material.

Plazomicin Gets Priority Review for Complicated UTI, Bloodstream Infections

By January 03, 2018

A 2016 Phase 3 trial (EPIC) including 609 patients with cUTI and acute pyelonephritis found plazomicin to be non-inferior to meropenum.

Eravacycline NDA Submitted for Complicated Intra-Abdominal Infections

By January 03, 2018

Eravacycline is a novel, fully-synthetic fluorocycline antibiotic being developed for the treatment of serious infections, including those caused by multidrug-resistant (MDR) pathogens that have been highlighted as urgent public health threats by both the World Health Organization and the U.S. Centers for Disease Control & Prevention (CDC).

Alternative Treatments for Mild Infections May Help Preserve Antibiotic Efficacy

By January 02, 2018

Antibiotic treatment of mild infections may be contributing greatly to resistance evolution.

Mold Discovered in Injectable Antibiotic Prompts Nationwide Recall

By December 27, 2017

Use of a non-sterile injectable product could result in fatal infections in a broad array of patients.

Novel Therapy Looks Promising for Treating Antibiotic-Resistant Bacteria

By December 26, 2017

The patient-the first to be treated with human polyclonal IgG harvested from Tc bovine-received infusions to combat the infection.

Can Probiotics Prevent <i>C. difficile</i>-Associated Diarrhea?

By December 20, 2017

Analysis of all patients who completed the study (N=8,672) found that probiotics reduce the risk of CDAD by 60%. Among the probiotic group the incident of CDAD was 1.5% (70/4,525) compared to 4% (164/4,147) in the placebo.

Studies Shed Light on Post-Treatment Lyme Disease Syndrome

By December 13, 2017

Despite testing negative by antibody tests for Lyme disease, two of 10 subjects were still infected with Lyme bacteria in heart and bladder.

FDA: New Tool to Help Clinicians Make Appropriate Antibiotic Choices

By December 13, 2017

New website streamlines how FDA updates information used to help health care providers choose an appropriate treatment for a patient's infection.

Hospital Admissions for <i>C. difficile</i> Infection and Acute Kidney Injury Increasing

December 13, 2017

Despite increase in admissions, inpatient mortality improved from 2003 to 2012