Bacterial Infections

Sanofi Discontinues <i>C. Difficile</i> Tx Development

By December 08, 2017

Data that has been collected from the trial so far will be analyzed and shared with the scientific community in due time.

Accuracy of Clinician Suspicion Tested Regarding Lyme Disease

November 27, 2017

Twelve percent of the 554 children who the treating clinicians thought were unlikely to have Lyme disease had Lyme disease, and 31% of those who the treating clinicians thought were very likely to have Lyme disease did not have Lyme disease.

CDC: Raw Milk May Be Contaminated With Rare, But Serious Bacteria

November 22, 2017

Case of New Jersey woman becoming ill after drinking raw milk from Udder Milk company

Antibiotic Combo for Cesarean Prophylaxis Linked to Better Maternal Outcomes

November 14, 2017

Improved maternal outcomes when azithromycin is added to cephalosporin for infection prophylaxis

NSAID Compared to Antibiotic for Symptomatic Treatment of UTI

By November 09, 2017

The primary endpoint of symptom resolution at day 3 was met by 54% (72/133) in the diclofenac group vs. 80% (96/120) in the norfloxacin group (risk difference 27%, 95% CI 15% to 38%, P=0.98 for non-inferiority, P<0.001 for superiority).

Vabomere Now Available for Complicated UTI, Pyelonephritis

By October 31, 2017

This combination antibiotic includes meropenem, a penem antibacterial, and vaborbactam, a non-suicidal beta-lactamase inhibitor.

Aemcolo Gets QIDP, Fast Track Designation for Travelers' Diarrhea

By October 31, 2017

In Phase 3 clinical trials involving patients with travelers' diarrhea, Aemcolo was found to be superior to placebo (P=0.0008) and non-inferior to ciprofloxacin.

Three Antimicrobial Susceptibility Tests Approved for Baxdela

By October 30, 2017

The newly cleared ASTs include: Hardy Diagnostics' Delafloxacin Antimicrobial Susceptibility Disk (HardyDisk), Liofilchem Delafloxacin MIC Test Strip (MTS), and Thermo Scientific Sensititre MIC System.

AAP Provides Update for Infection Prevention in Pediatrics

October 23, 2017

"In this policy, we emphasize the importance of public health interventions, including vaccination for patients and health care personnel," the authors write.

Antibiotics May Reduce Infection Risk Post-Colorectal CA Surgery

October 19, 2017

The researchers found that patients who received oral antibiotics and MBP had a lower overall SSI rate than those who received MBP only (8 versus 27%; P=0.03).

Combo Antibiotic Gets Priority Review for New Pneumonia Indication

By October 13, 2017

Avycaz is a combination antibiotic consisting of ceftazidime, a cephalosporin, and avibactam, a beta-lactamase inhibitor.

Leprosy Vaccine Candidate to Be Tested in Humans

By October 12, 2017

Leprosy (also known as Hansen's disease) is caused by the Mycobacterium leprae bacteria and results in disfiguration of the skin and mucous membranes as well as incurable nerve damage.

Statin Use May Decrease Risk of Community-Acquired Staph Infection

October 11, 2017

The researchers found that compared with nonusers, current statin users experienced markedly decreased risk of CA-SAB (adjusted odds ratio [OR], 0.73; 95% confidence interval, 0.63 to 0.84).

Test Helps Clinicians Select Appropriate Tx for Suspected Wound Infections

By October 05, 2017

Using a simple swab from the infection site, DxWound uses a special transport buffer that preserves the wound microbiome during transit.

Antibiotic Combo Tx May Up Risk of Acute Kidney Injury in Children

October 03, 2017

Risk of AKI in hospitalized children higher than with IV vancomycin, other antipseudomonal -lactam

CDC: Sexually Transmitted Diseases Hit 'Record High' in U.S.

By September 26, 2017

The majority of syphilis infections are seen particularly in gay, bisexual, and other men who have sex with men (MSM), of which half are also diagnosed with HIV.

Linhaliq NDA Granted Priority Review

By September 25, 2017

Linhaliq was previously granted Qualified Infectious Disease Product (QIDP) Designation and Fast Track designation for NCFBE with lung infections with P. aeruginosa.

AAP Explores Major Infectious Disease Risk Factors in Team Sports

September 25, 2017

The researchers found that skin-to-skin contact with athletes who have active skin infections, environmental exposures, and physical trauma are major risk factors for infection, as well as sharing of equipment and contact with contaminated fomites.

Hair Regrowth in Alopecia Patients After Fecal Transplant for Recurrent CDI

By September 22, 2017

These 2 cases suggests that fecal transplants can have a profound immunological response not only limited to intestinal effects, say the authros.

Prophylactic Antibiotic Course Post C-Section May Reduce SSI Rate

September 20, 2017

The researchers found that the overall rate of SSI was 10.9% in the cohort. Overall, 6.4 and 15.4% of women in the cephalexin-metronidazole and placebo groups, respectively, were diagnosed with SSI (relative risk, 0.41).

Phase 3 Results of Novel CABP Treatment Announced

By September 18, 2017

A second 'LEAP 2' trial is currently in the midst of enrolling patients and expected to have topline results in the spring of 2018.

Baxdela Yields High Response Against Fluoroquinolone-Non-Susceptible MRSA

By September 18, 2017

Baxdela also yielded high response rates against S. aureus isolates with mutations in the Quinolone Resistance Determining Region (QRDR) in 98.8% of cases. QRDR mutations lower the fluoroquinolone binding and increase resistance.

AAP Publish First Guidance on Tattooing, Piercing for Adolescents

By September 18, 2017

These can occur from contamination of the inks or diluents used for tattooing.

Single-Dose Oral Therapy for Bacterial Vaginosis Gets Approval

By September 18, 2017

The approval was based on two randomized, placebo-controlled studies which evaluated the efficacy of Solosec in the treatment of bacterial vaginosis.

Antibiotic Class Linked to Increased Risk of GI Perforation

By September 18, 2017

The researchers compared a cohort of 17,510 individuals diagnosed with GI perforation to a matched group of 1,751,000 controls.

Plans Stepped Up to Curb San Diego Hepatitis Outbreak

By September 12, 2017

Streets will be power-washed by crews using bleach-spiked water to clean what, in a letter the County called a "fecally contaminated environment".

Current Diagnostic Tools Failing to ID Bacterial Infections in Infants

September 12, 2017

Sensitivities were low for common complete blood cell count thresholds: white blood cell count <5,000/µL, 10%; white blood cell count ≥15,000/µL, 27%; absolute neutrophil count ≥10,000/µL, 18%; and platelets <100 × 10³/µL, 7%.

CDC: Pet Store Chain Source of Multistate <i>Campylobacter</i> Outbreak

September 12, 2017

Nine people have been hospitalized but no deaths have been reported.

Bacterial Transmission from Guinea Pigs Linked to Three Cases of CAP

September 08, 2017

Three cases of community-acquired pneumonia reported after exposure to ill guinea pigs

Race May Play Role in Antibiotic Rx Trends for Pediatric ARTI

September 06, 2017

The researchers found that 2.6% of the PED encounters for viral ARTIs resulted in patient receipt of antibiotics, including 4.3, 1.9, 2.6, and 2.9% of non-Hispanic white, non-Hispanic black, Hispanic, and other non-Hispanic children, respectively.