AZILECT
Generic Name for AZILECT
Rasagiline 0.5mg, 1mg; tabs.
Legal Classification:
Rx
Pharmacological Class for AZILECT
MAO-B inhibitor.
Manufacturer of AZILECT
Teva Neuroscience
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Indications for AZILECT
Idiopathic Parkinson's disease, as initial monotherapy and as an adjunct to levodopa.
Adult dose for AZILECT
Monotherapy: 1mg once daily. Adjunctive therapy: initially 0.5mg once daily; may increase to 1mg once daily (consider reducing levodopa dose if side effects increase). Mild hepatic impairment (Child-Pugh score 5–6) or concomitant CYP1A2 inhibitors: 0.5mg once daily.
Children's dosing for AZILECT
Not recommended.
Contraindications for AZILECT
During or within 2 weeks of meperidine, tramadol, propoxyphene, methadone, MAOIs. Concomitant dextromethorphan, St. John's wort, cyclobenzaprine.
Warnings/Precautions for AZILECT
Avoid tyramine-rich foods (see literature). Mild hepatic impairment: reduce dose; moderate to severe hepatic impairment (Child-Pugh score ≥7): not recommended. Monitor for melanoma. Pregnancy (Cat.C). Nursing mothers.
Interactions for AZILECT
See Contraindications. Possible hypertensive crisis with excess dietary tyramine (see literature). Potentiated by CYP1A2 inhibitors (eg, ciprofloxacin). Severe CNS toxicity (hyperpyrexia, death) with triazolopyridines, tricyclics, tetracyclics, SSRIs, SNRIs, and MAOIs (both nonselective and type B selective); allow at least 14 days after discontinuing rasagiline before starting triazolpyridines, tricyclics, tetracyclics, SSRIs, or SNRIs; allow 5 weeks after discontinuing fluoxetine before starting rasagiline. Caution with sympathomimetics (eg, nasal, oral, ophthalmic decongestants or cold remedies).
Adverse Reactions for AZILECT
As monotherapy: flu syndrome, arthralgia, depression, dyspepsia. With levodopa: also dyskinesia, accidental injury, weight loss, postural hypotension, GI upset, anorexia, abdominal pain, constipation, dry mouth, rash, abnormal dreams, fall.
How is AZILECT supplied?
Tabs—30
Related Disease:
Parkinsonism