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AVELOX
Bacterial infections
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Drug Name:

AVELOX Rx

Generic Name and Formulations:
Moxifloxacin (as HCl) 400mg; tabs.

Company:
Bayer Healthcare Pharmaceuticals Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for AVELOX:

Susceptible bacterial infections including acute sinusitis, acute exacerbations of chronic bronchitis, community acquired pneumonia, skin and skin structure, complicated intra-abdominal infections.

Adult Dose for AVELOX:

≥18yrs: 400mg once daily. Sinusitis: treat for 10 days. Bronchitis: treat for 5 days. Pneumonia: treat for 7–14 days. Skin and skin structure: treat for 7 days, if complicated: 7–21 days. Intra-abdominal: treat for 5–14 days; use IV form first. IV form: infuse over 60 minutes.

Children's Dose for AVELOX:

<18yrs: not recommended.

See Also:

AVELOX I.V.

Pharmacological Class:

Quinolone.

Warnings/Precautions:

Increased risk of tendinitis and tendon rupture esp. in patients >60yrs, or those with kidney, heart or lung transplants. CNS disorders (eg, seizures). Discontinue if tendon pain, inflammation, or rupture occurs; or if allergic reaction or CNS events occur. Severe hepatic impairment. History of QT prolongation or proarrhythmic conditions (eg, hypokalemia, bradycardia, acute myocardial ischemia). Do not exceed recommended dose or infusion rate; may increase QT prolongation. Maintain adequate hydration. Avoid excessive sun or UV light. Pregnancy (Cat.C), nursing mothers: not recommended.

Interactions:

Avoid drugs that prolong QTc interval (eg, Class IA or Class III antiarrhythmics, erythromycin, antipsychotics, tricyclics). Oral forms: take at least 4 hours before or 8 hours after iron, zinc, magnesium, aluminum, sucralfate, didanosine (buffered forms). Increased risk of tendinitis and tendon rupture with corticosteroids. Monitor warfarin. Concomitant NSAIDs may increase seizure risk.

Adverse Reactions:

GI upset, dizziness, headache, convulsions, other CNS effects, abdominal pain, inj site reaction, taste perversion; hypersensitivity reactions, abnormal liver function tests, rash, phototoxicity (discontinue if occurs), tendinitis/rupture; rare: peripheral neuropathy.

How Supplied:

Tabs—30; ABC Pack (5 tabs)—1; Premixed IV soln (250mL)—1