AVELOX

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Generic Name for AVELOX

Moxifloxacin (as HCl) 400mg; tabs.

Legal Classification:

Rx

Pharmacological Class for AVELOX

Quinolone.

Manufacturer of AVELOX

Bayer Corp, Pharmaceutical Div.

Indications for AVELOX

Susceptible bacterial infections including acute sinusitis, acute exacerbations of chronic bronchitis, community acquired pneumonia, skin and skin structure, complicated intra-abdominal infections.

Adult dose for AVELOX

≥18yrs: 400mg once daily. Sinusitis: treat for 10 days. Bronchitis: treat for 5 days. Pneumonia: treat for 7–14 days. Skin and skin structure: treat for 7 days, if complicated: 7–21 days. Intra-abdominal: treat for 5–14 days; use IV form first. IV form: infuse over 60 minutes.

Children's dosing for AVELOX

<18yrs: not recommended.

Also:

Warnings/Precautions for AVELOX

Increased risk of tendinitis and tendon rupture esp. in patients >60yrs, or those with kidney, heart or lung transplants. CNS disorders (eg, seizures). Discontinue if tendon pain, inflammation, or rupture occurs; or if allergic reaction or CNS events occur. Severe hepatic impairment. History of QT prolongation or proarrhythmic conditions (eg, hypokalemia, bradycardia, acute myocardial ischemia). Do not exceed recommended dose or infusion rate; may increase QT prolongation. Maintain adequate hydration. Avoid excessive sun or UV light. Pregnancy (Cat.C), nursing mothers: not recommended.

Interactions for AVELOX

Avoid drugs that prolong QTc interval (eg, Class IA or Class III antiarrhythmics, erythromycin, antipsychotics, tricyclics). Oral forms: take at least 4 hours before or 8 hours after iron, zinc, magnesium, aluminum, sucralfate, didanosine (buffered forms). Increased risk of tendinitis and tendon rupture with corticosteroids. Monitor warfarin. Concomitant NSAIDs may increase seizure risk.

Adverse Reactions for AVELOX

GI upset, dizziness, headache, convulsions, other CNS effects, abdominal pain, inj site reaction, taste perversion; hypersensitivity reactions, abnormal liver function tests, rash, phototoxicity (discontinue if occurs), tendinitis/rupture; rare: peripheral neuropathy.

How is AVELOX supplied?

Tabs—30
ABC Pack (5 tabs)—1
Premixed IV soln (250mL)—1

Related Disease:

Bronchitis, chronic
Infections, bacterial~systemic antiinfectives
Pneumonia
Sinusitis

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