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AVAPRO
Diabetes
Hypertension
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Drug Name:

AVAPRO Rx

AVAPRO (irbesartan) 75mg, 150mg, 300mg tablets by Sanofi Aventis

Generic Name and Formulations:
Irbesartan 75mg, 150mg, 300mg; tabs.

Company:
Sanofi Aventis

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Therapeutic Use:

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Indications for AVAPRO:

Treatment of diabetic nephropathy in patients with type 2 diabetes and hypertension.

Adult Dose for AVAPRO:

300mg once daily.

Children's Dose for AVAPRO:

Not recommended.

Pharmacological Class:

Angiotensin II receptor blocker.

Contraindications:

Concomitant aliskiren in patients with diabetes.

Warnings/Precautions:

Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before beginning therapy, or reduce initial dose. Renal impairment. Severe CHF. Renal artery stenosis. Elderly. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers: not recommended.

Interactions:

Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. May be antagonized by NSAIDs including COX-2 inhibitors. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended.

Adverse Reactions:

Diarrhea, dyspepsia, fatigue, orthostatic hypotension, hyperkalemia; rhabdomyolysis (rare).

Metabolism:

Hepatic (CYP2C9). 90% protein bound.

Elimination:

Biliary, renal.

Generic Availability:

YES

How Supplied:

Tabs 75mg—30, 90; 150mg, 300mg—30, 90, 500

Indications for AVAPRO:

Hypertension.

Adult Dose for AVAPRO:

≥16yrs: 150mg once daily; may increase to 300mg once daily. Or, may add a low dose of diuretic. Salt/volume depletion: initially 75mg once daily.

Children's Dose for AVAPRO:

Not recommended.

Pharmacological Class:

Angiotensin II receptor blocker.

Contraindications:

Concomitant aliskiren in patients with diabetes.

Warnings/Precautions:

Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before beginning therapy, or reduce initial dose. Renal impairment. Severe CHF. Renal artery stenosis. Elderly. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers: not recommended.

Interactions:

Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. May be antagonized by NSAIDs including COX-2 inhibitors. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended.

Adverse Reactions:

Diarrhea, dyspepsia, fatigue; rhabdomyolysis (rare).

Metabolism:

Hepatic (CYP2C9). 90% protein bound.

Elimination:

Biliary, renal.

Generic Availability:

YES

How Supplied:

Tabs 75mg—30, 90; 150mg, 300mg—30, 90, 500