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ATIVAN INJECTION
Anesthetics
Seizure disorders
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Drug Name:

ATIVAN INJECTION CIV

Generic Name and Formulations:
Lorazepam 2mg/mL, 4mg/mL; soln for IV inj after dilution or IM inj; contains polyethylene glycol 400 in propylene glycol, benzyl alcohol.

Company:
West-Ward Pharmaceutical Corp.



Therapeutic Use:

Indications for ATIVAN INJECTION:

Preanesthetic to produce sedation, anxiety relief, and diminished recall of events related to surgery.

Adult Dose for ATIVAN INJECTION:

Individualize. ≥18yrs: IM: Give 2 hours prior to surgery. 0.05mg/kg, max 4mg. IV: Give 15–20 minutes prior to surgery. 0.044mg/kg or 2mg total, whichever is lower, may increase dose to 0.05mg/kg up to max 4mg if diminished recall of events related to surgery is desired; >50yrs: max IV dose of 0.044mg/kg or 2mg total, whichever is lower.

Children's Dose for ATIVAN INJECTION:

<18yrs: not recommended.

Pharmacological Class:

Benzodiazepine.

Contraindications:

Acute narrow-angle glaucoma. Sleep apnea. Severe respiratory insufficiency (except as preanesthetic during mechanical ventilation). Intra-arterial injection.

Warnings/Precautions:

Monitor respiration and level of sedation; ensure availability of resuscitative equipment for ventilatory support. Fall risk. Critically ill. Limited pulmonary reserve. Hepatic or renal failure: not recommended; caution with mild to moderate hepatic/renal disease. Elderly. Avoid extravasation. Outpatient endoscopy. Labor and delivery, pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Additive CNS effects with alcohol, phenothiazines, narcotic analgesics, barbiturates, antidepressants, and MAOIs. Caution with concurrent administration of scopolamine, loxapine, clozapine, haloperidol, or other CNS depressant drugs. May be antagonized by oral contraceptives (may need to increase lorazepam dose). Potentiated by valproate and probenecid (reduce lorazepam dose by 50%).

Adverse Reactions:

Respiratory depression/failure, hypotension, somnolence, headache, apnea, excessive sleepiness and drowsiness, inj site reaction, paradoxical reactions.

How Supplied:

Single-use vials—25
Multiple-dose vials (10mL)—10

Indications for ATIVAN INJECTION:

Status epilepticus.

Adult Dose for ATIVAN INJECTION:

Individualize. ≥18yrs: Give by IV inj. 4mg at a rate of 2mg/min; may repeat dose once in 10–15 minutes if seizures continue or recur.

Children's Dose for ATIVAN INJECTION:

<18yrs: not recommended.

Pharmacological Class:

Benzodiazepine.

Contraindications:

Acute narrow-angle glaucoma. Sleep apnea. Severe respiratory insufficiency (except as preanesthetic during mechanical ventilation). Intra-arterial injection.

Warnings/Precautions:

Monitor respiration and level of sedation; ensure availability of resuscitative equipment for ventilatory support. Fall risk. Critically ill. Limited pulmonary reserve. Hepatic or renal failure: not recommended; caution with mild to moderate hepatic/renal disease. Elderly. Avoid extravasation. Outpatient endoscopy. Labor and delivery, pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Additive CNS effects with alcohol, phenothiazines, narcotic analgesics, barbiturates, antidepressants, and MAOIs. Caution with concurrent administration of scopolamine, loxapine, clozapine, haloperidol, or other CNS depressant drugs. May be antagonized by oral contraceptives (may need to increase lorazepam dose). Potentiated by valproate and probenecid (reduce lorazepam dose by 50%).

Adverse Reactions:

Respiratory depression/failure, hypotension, somnolence, headache, apnea, excessive sleepiness and drowsiness, inj site reaction, paradoxical reactions.

How Supplied:

Single-use vials—25
Multiple-dose vials (10mL)—10

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