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ATIVAN INJECTION to:
Generic Name for ATIVAN INJECTION
Lorazepam 2mg/mL, 4mg/mL; soln for IV inj after dilution or IM inj; contains polyethylene glycol 400 in propylene glycol, benzyl alcohol.
Legal Classification:
CIV
Pharmacological Class for ATIVAN INJECTION
Benzodiazepine.
Manufacturer of ATIVAN INJECTION
Baxter
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Indications for ATIVAN INJECTION
Preanesthetic to produce sedation, anxiety relief, and diminished recall of events related to surgery.
Other Indications for ATIVAN INJECTION
Adult dose for ATIVAN INJECTION
Individualize. ≥18yrs: IM: Give 2 hours prior to surgery. 0.05mg/kg, max 4mg. IV: Give 15–20 minutes prior to surgery. 0.044mg/kg or 2mg total, whichever is lower, may increase dose to 0.05mg/kg up to max 4mg if diminished recall of events related to surgery is desired; >50yrs: max IV dose of 0.044mg/kg or 2mg total, whichever is lower.
Children's dosing for ATIVAN INJECTION
<18yrs: not recommended.
Contraindications for ATIVAN INJECTION
Acute narrow-angle glaucoma. Sleep apnea. Severe respiratory insufficiency (except as preanesthetic during mechanical ventilation). Intra-arterial injection.
Warnings/Precautions for ATIVAN INJECTION
Monitor respiration and level of sedation; ensure availability of resuscitative equipment for ventilatory support. Fall risk. Critically ill. Limited pulmonary reserve. Hepatic or renal failure: not recommended; caution with mild to moderate hepatic/renal disease. Elderly. Avoid extravasation. Outpatient endoscopy. Labor and delivery, pregnancy (Cat.D), nursing mothers: not recommended.
Interactions for ATIVAN INJECTION
Additive CNS effects with alcohol, phenothiazines, narcotic analgesics, barbiturates, antidepressants, and MAOIs. Caution with concurrent administration of scopolamine, loxapine, clozapine, haloperidol, or other CNS depressant drugs. May be antagonized by oral contraceptives (may need to increase lorazepam dose). Potentiated by valproate and probenecid (reduce lorazepam dose by 50%).
Adverse Reactions for ATIVAN INJECTION
Respiratory depression/failure, hypotension, somnolence, headache, apnea, excessive sleepiness and drowsiness, inj site reaction, paradoxical reactions.
How is ATIVAN INJECTION supplied?
Single-use vials—25
Multiple-dose vials (10mL)—10