Asthma/COPD

Fluticasone Furoate Slows Lung Function Decline in COPD

August 04, 2017

The researchers found that FF-containing regimes had lower rates of decline than placebo (P<0.03), and FF/VI had lower rates of decline than VI alone (P<0.005).

Investigational Nebulized LAMA Shows Promise in COPD Trial

By July 19, 2017

Results found that rates of COPD exacerbations were lowest in the 175mcg treatment arm. Also, the adverse events and serious adverse events in the revefenacin group were comparable to the tiotropium group.

Does Asthma Inadvertently Protect Against Life-Threatening Infections?

June 23, 2017

The researchers found that patients with asthma had decreased risk for hospital mortality, septicemia, sepsis, severe sepsis, and septic shock (adjusted odds ratios, 0.41, 0.60, 0.59, 0.60, and 0.74, respectively) across all infections in the 2012 NIS data.

CVD Comorbidity May Influence Bronchodilator Prescribing in COPD

By June 02, 2017

Given the potential cardiovascular side effects associated with bronchodilators, clinicians may be hesitant to prescribe the therapy to COPD patients with CVD.

Case: Inhaled Corticosteroid-Induced Myopathy in HIV Patient

By May 26, 2017

Initially, the team attributed the muscle weakness to either HIV or drug-mediated myopathy but a muscle biopsy later revealed atrophy of type II fibers without necrosis or inflammation.

Utibron Neohaler Reduces Nighttime Symptoms, Improves Lung Function in COPD Studies

By May 23, 2017

Two additional pooled analyses of FLIGHT1 and FLIGHT2 showed that treatment with Utibron Neohaler led to significant reduction in total nighttime COPD symptoms score vs. placebo over 12 weeks.

Spiriva Respimat Improves Lung Function in Difficult-to-Treat Patients

By May 23, 2017

Post hoc analyses of some Phase 3 placebo-controlled studies showed that adding Spiriva Respimat improved peak FEV1(0-3h) and trough FEV1 across a range of baseline IgE levels and eosinophil counts.

Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma

By May 22, 2017

Nair, P, MD, PhD. Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma. DOI: 10.1056/NEJMoa1703501.

Benralizumab Use Cuts Need for Oral Steroids in Severe Asthma

By May 22, 2017

The primary endpoint was met with 75% of the benralizumab group reducing their OCS doses compared to 25% in the placebo group. Additionally, 52% of the benralizumab group who had optimized baseline OCS doses of ≤12.5mg/d were able to completely stop OCS use.

Testosterone May Safeguard Against Asthma

May 10, 2017

Lymphoid cells produce proteins that can lead to lung inflammation and damage when exposed to asthma allergens, such as pollen. When ILC2s detect testosterone, the cells stop reproducing, the researchers found.

Can a Thunderstorm Trigger an Asthma Outbreak?

May 02, 2017

A thunderstorm in Australia in 2016 resulted in multiple deaths and a surge of people seeking medical help for breathing problems.

Oral Corticosteroid Use May Up Risk of Adverse Effects in Asthma Patients

By May 01, 2017

Compared to the control group, patients who took four or more oral corticosteroid prescriptions had 1.29 times the odds of experiencing a new adverse effect within the year.

AirDuo RespiClick, Authorized Generic Now Available for Asthma

By April 20, 2017

The inhalers are available to treatment of asthma in patients 12 years of age and older who are uncontrolled on an inhaled corticosteroid or whose disease severity clearly warrants the use of an ICS/long-acting beta2-adrenergic agonist combination.

Home-Use Wireless Spirometer Gets FDA Clearance

By April 18, 2017

The device can collect forced spirometry (FVC) and slow spirometry (SVC) with the same accuracy as hospital laboratory systems and provides immediate feedback to patients.

Utibron Neohaler Available for COPD

By April 04, 2017

Utibron Neohaler Inhalation powder is indicated for the long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.

Inhaled Corticosteroid Use May Up Metabolic Syndrome Risk

By April 04, 2017

Patients who used corticosteroids had a 1.1-fold increased risk of having metabolic syndrome vs. corticosteroid non-users and the likelihood was more pronounced in women than in men.

Serum Periostin Investigated as Rhinosinusitis Identifier

March 21, 2017

Receiver operating curve analyses showed moderate and high diagnostic accuracy for detecting chronic rhinosinusitis and chronic rhinosinusitis with nasal polyps, respectively.

Can ACEIs, ARBs Slow Emphysema Progression?

March 17, 2017

The median percent emphysema was 3.0 at baseline, and over a median of 9.3 years the rate of progression was 0.64%.

Simple Measure May Reduce Severity of Childhood Asthma Flares

March 14, 2017

Children with protective bedding went much longer before having an exacerbation that led to an emergency room visit or hospital stay for treatment with systemic corticosteroids.

Do Inhaled Corticosteroids Up Pneumonia Risk in Children with Asthma?

February 27, 2017

No increased risk of pneumonia; no link for ICS with risk of pharyngitis, otitis media, sinusitis

Two Asthma Meds Show Promise in Halting Lethal Pneumonia

February 27, 2017

A mice model demonstrated that treating severe influenza with Singulair or Accolate may prevent severe pneumonia.

Healthy Diet May Lower COPD Risk

February 24, 2017

In current smokers, each extra daily serving tied to an 8 percent lower risk

Efficacy of COPD Combo Therapies Compared

By February 23, 2017

Clinical guidelines currently recommend LABA/LAMA therapy as an alternative to LABA/ICS but evidence on the comparative effectiveness of these combination therapies for COPD is limited.

Spiriva Respimat Gets Expanded Approval for Pediatric Asthma Maintenance

By February 16, 2017

This approval was based on efficacy and safety data from the Phase 2 and Phase 3 UniTinA-asthma clinical development program.

Tiotropium as Add-On Therapy in Severe Symptomatic Asthma

By February 10, 2017

Stanley J. Szefler, MD , Kevin Murphy, MD, Thomas Harper III, MD, Attilio Boner, MD, István Laki, MD, Michael Engel, MD, Georges El Azzi, MD, Petra Moroni-Zentgraf, MD, Helen Finnigan, MSc, Eckard Hamelmann, MD. 'A phase III randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma'

Omega-3 Fatty Acids and Asthma: Why Do Outcomes Vary?

By February 09, 2017

Omega-3 fatty acids contained in fish oil was shown to have a lowering effect on lgE production (the antibodies which fuel asthma), suggesting that omega-3 fatty acids may be utilized to treat asthma patients.

Chronic Insomnia May Increase Asthma Risk

February 03, 2017

Insomnia may increase the risk of asthma in adults, according to research published online February 1 in the European Respiratory Journal.

Two New Breath-Activated Inhalers Gain FDA Approval for Asthma

By January 30, 2017

AirDuo RespiClick and ArmonAir RespiClick are expected to be available later this year.

Symbicort Gains New Pediatric Indication for Asthma

By January 30, 2017

The pediatric approval was based on the results of the Phase 3 CHASE (ChildHood Asthma Safety and Efficacy) 3 trial.

Does Pneumococcal Vaccination Reduce Pneumonia Risk in COPD?

By January 26, 2017

A Cochrane review found that polyvalent pneumococcal vaccines offered significant protection against community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients, however, the evidence did not show that vaccination lowered the risk of confirmed pneumococcal pneumonia.